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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

New RCs in the UK Ver.3 - Get your disappointment in here

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Shambles said:
^^ Instigator = look at the new mod titles ;)

Ethylphenidate has been around for a while but been very stop-start supply and half of that was probably scams and bunk which is why I'm waiting for more reliable reports on it. Was a flurry of reports last year but no idea if it was legit. Reports were mixed but mostly not that great.
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I wrote a review last year, overall it was pretty worthless, only got decent euphoria when smoked and went to the whole gram in a matter of hours, almost no stimulation, little to no effects when snorted or swallowed.

Wouldn't buy it again.
 
Is ethylphenidate formed in the blood when you drink on methylphenidate? I think I read that somewhere. Booze always seemed to extend the effects of ritalin in a subtle at the time yet pronounced in retrospect sort of way.
 
^I think that could well be the case, just making the comparison between that process and cocaine-cocaethylene, but I'm no expert.
 
I've just ordered a lot of 6-APB powder for dirt cheap. He said he is expecting it to go illegal soon and is trying to get rid of it. I'm sceptical as to what this shit will even be.

Are there varying batches floating around; of the powder, not pellets?
 
yoyo50 said:
Sounds like your have shit, i think there are very few places that sell the real deal besides the **Mutha Ucka** 5, and ive heard nothing about it going illegal.
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I'm not expecting much, but not exactly a loss.

Do those circle jerking 5 actually sell legit products? I know one of them during legal mephedrone times sold quite a bit of bunk shit, and I will not go through anyone remotely to do with that particular vendor. They are all tarred with the same brush.
 
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IIRC transesterification does occur with methylphenidate, but to a very, very minimal extent.
I don't remember figures off the top of my head, but at any sane dose of MPH, it shouldn't produce enough ethylphenidate to make any difference really.

Also unlike coke, it isn't going to cause greatly enhanced likliehood of heart problems, the cardiotoxicity of coke is due to its local anaesthetic action, which can cause arrythmias, the sodium channel blocking action being just like that of lidocaine, which is a class II antiarrythmic agent (sounds paradoxical I know, but just because a drug can be used to treat heart problems of certain natures, it doesn't mean they cannot cause some of their own, particularly in somebody who is not already experiencing the problem which would be suited for treatment thus)
 
Didn't think this justified its entire thread and I don't know enough to post about it in ADD so....

Why can I find no information regarding 3,4,5-trimethoxy-cathinone or 3,4,5-trimethoxy-methcathinone? Cathinone analogues of Mescaline and TMA.

Would they dimerize to form a piperazine in a similar way to the cathinone analgoues of the DOx compounds?
 
3,4,5-trimethoxycathinone is the bk analogue of TMA, 3,4,5-trimethoxymethcathinone would be the bk analogue of TMMA. The former would be unstable, as you say, the latter would be stable but TMMA is basically unknown AFAIK, a quick google mentions one person having ever taken them, it doesn't seem to have aroused much interest. In any case, wouldn't the 2,4,5 isomers be more interesting (well, more potent at least)? And you do know that these compounds would be illegal in the UK?

For future reference, ADD has this rather nice thread:
The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread
for those of us who aren't able to post at ADD standard but who want to ask questions of those in the know.
 
@Yerg

Thanks for that, it'd been on my mind for a while considering some of the obscure cathinones that seem to be available.
I'll bear that ADD thread in mind for the furure


Yerg said:
And you do know that these compounds would be illegal in the UK?
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Yeah, I thought that this, combined with the analogue act in USA may have been a reason for them not being looked into. Them being equally as illegal and not as good as their amphetamine counterparts.
 
Almost all of the psychedelic phenethylamines would make for unstable cathinones, whilst a tert. amine is next-door neighbour to a requirement for a tryptamine, the secondary amine derivatives of the phenethylamines seem not to be oriented the same way towards heavily psychedelic activity, but appear to possess somewhat of the nature of anti-depressants.

The n-(2-MeO-benzyl) derivatives though are fucking potent, on a weight basis, active in many cases in micrograms, to low milligram quantities in others. This appears only to hold true for the phenethylamines lacking the alpha-CH3 substituent though, the psychedelic amphetamine counterparts have been reported to be only weak partial agonists at 5HT2a.

That said, I am curious, if that actually translates, in practise, to an inactive drug, or at best, a poorly active one. Weight potency surely will be down, but quantity does not equal quality when we are talking of psychedelics. Look at the potency of mescaline, for instance, requiring at least a couple of hundred milligrams of the hydrochloride salt (more if the more common sulfate is used, given the much heavier counterion species busy being sat there on that amine, adding extra weight)

Mescaline is meant to be a real gem, definately one on my list to try, and contrast it with, lets say, 5-MeO-AMT, which is fully active at 2-3mg, and by all accounts, sounds utterly foul.

I should be trying 2C-D and DOM in the not too distant future, which means access to the corresponding n-(2-methoxybenzyl) derivatives, giving the bomamine-derivative of the amphetamine is definately a priority, despite the reported low Ki values and efficacy for the alpha-methylated derivatives of that series, in fact, perhaps not despite that, but because of it. Still warrants investigation in my opinion, we don't learn more about phenethylamine SAR by ignoring ones that are almost certainly of low potency.


As far as the cathinones go, primary beta-C=O phenethylamines are unstable as the freebase, and form dimeric degredation products pretty quickly in high concentrations. A salt should be more stable however.

One thing that certainly could be done though, I think, is preparation of the appropriate ring-substituted pthalimidopropiophenones, pthalimidopropiophenone itself made an appearance a while back as a cathinone prodrug, and liberating the drug in the body, the concentrations are not going to be such that those dimers are likely to form, especially given how low the dose may potentially be, of the cathinone counterparts to potent psychedelic phenethylamines/'phets.



Anybody know if the 'bomamines' are illegal in the UK?
 
Thread-bumper that you are.
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Just can't let it go, can you? ;)

Any compound (not being Methoxyphenamine or a compound for the time being specified in sub-paragraph (a) above) structurally derived from Phenethylamine, an N-alkylphenethylamine, α-methylphenethylamine, an N-alkyl-α-methylphenethylamine, α-ethylphenethylamine, or an N-alkyl-α-ethylphenethylamine by substitution in the ring to any extent with alkyl, alkoxy, aklylenedioxy or halide substituents, whether or not further substituted in the ring by one or more other univalent substituents.
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My understanding of that clause led me to believe that the NBOMes are legal, but nuke is a lot more clued up than I am and if she's unsure, then it must be a grey area.

Mescaline is meant to be a real gem, definately one on my list to try
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A man with your level of chemical competence should encounter little difficulty acquiring mescaline.
 
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When I do it will be my first experience with any of the psychedelic phenethylamines/amphetamines, I'm no psychedelic virgin, but all my experience has been with tryptamines, Salvia divinorum, lysergamides or dissociatives (diethyl and diisopropyl ether, ket, MXE-definately going to buy another gram of MXE, and possibly some tiletamine, or one of the recently released PCP derivatives and get it sent here express before I go for my steroid injection...I have a thing about needles, I hate them, big time, and only really handle it well if I am the one actually performing an injection, but damned if I can pilot a needle deep into my own knee joint...I couldn't trust myself to do it accurately).

Only experience with simply-structured phenethylamines/'phets that aren't the common pure stimulants, such as amp, meth, khat, methcathinone, 2-aminoindan and N-ethyl amphetamine has been MDMA and methylone, although I am not a big fan of empathogens thus far, being autistic and having a drug effect artificially induce social-itis feels very strange to me, and somehow false, constructed and artificial.

NEARLY had a go with DOI, got quite a bit of it almost half a decade ago, but I never got to taste it, as I unfortunately for me, got myself into a nasty situation with a large barbiturate monkey on my back at the time, and to top off nearly dying from an OD, and a very prolonged acute withdrawal and the DTs, it was spent in the shitcan, after some fucker of a paramedic narked me up for possession, and the filth raided the place, trashed everything and took a whole fucking load of scientific equipment/supplies, a bin liner full of nitrous canisters and a large toolbox full of my entire stash.

The DOI...JUST arrived in the mail at the time, a day or two later and it would have been waiting for me when I got out of prison, but no, the fuckers fucking fucked it :(

Have you had DOM before samhaingrim? I would say I chose that for my first experience with one of the amps/phens because of its reputation as a true classic, but I kind of screwed up, half asleep said one thing and meant another to somebody. It was meant to be aleph-7 and 2C-T-7, so those will have to be next on my list :)

I do need to upgrade my scales though, currently mine only goes down to 10mg, I don't have any great worries about weighing out 2C-D on that, easy enough to do a volumetric dilution of a larger amount than the dose intended either in a solvent fit for ingestion orally, or something very volatile, that can be spotted onto a petri dish in an appropriate amount, and left to evaporate for snorting, or whatever the buggery else might get planned for it.

DOM on the other hand....another matter entirely, and as for the bomamine of either, 25D-nBOMe is FULLY active at 1mg according to reports on BL, whilst the DOM-derivative, may or may not be active at all, may take quite a large dose, most likely is down on weight potency, but as far as I know, it has never been tasted, thats not to say somebody hasn't, but certainly by nobody I have ever heard of....and hell if I am weighing a drug related to something active in the microgram range, and a complete unknown at that, on a scale accurate to 10mg? you have to be fucking shitting me!

The penalty one would potentially pay for a significant screwup with something like that, is not something I intend to find out. The tryptamines seem a lot more forgiving as far as toxicological profiles go, I don't weigh out DMT, nor 5-MeO-DALT, unless very specifically doing so to gain a sense of appreciation for the effects of a specific dosage, and getting a bit too much isn't likely to cause any serious physical harm, but on something like a DOx, with a damn steep dose response curve, or these new (2-MeO-Bn) phenethylamines, the end result of stupidity, or carelessness is going to be a lot more unpleasant, or potentially fatal.

And I rather like living...besides, my other half would not be at all pleased with me if I ended up having bodyparts drop off, they are all her property, so I can't really afford to make that mistake.
 
Never done DOM sadly, LC. I'd very much like to. I've had DOB, but that's as far as my DOx experience goes.

DOM's the one I've had a crush on (alas from afar) for many years.
 
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