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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

New (and less new) RCs - Alphabet Soup

SproutOnSmack said:
Disregarding being an AB and the massive issues that brings to the table, ultra-selective DRI's are usually tosh.
Plus, the purported potentiation of, antagonists of D1/2/3/4 AND 5HT-1/2A, not to mention σ sites, typical AP's worries me....

A question: as a supposed USDRI, is it possible that the inhibition is so rapid and complete that the DA system, and thus flow of Dopamine, grinds to a near halt?
If little/no DA is present, complete blockade of reuptake proteins would produce little physiological effects, at least in the manner assumed on this board. The activity at NET being roughly zero would render no 'speedy', subjectively stimulating, effects.

To surmise; an all-but-damp squib as a recreational psychotropic, rather; an anti-biotic, anti-psychotic that adds weight to the 'DA selectivity without NE activity renders DrugX undesirable' notion.
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Your "actual knowledge" words sounds about spot on to me with my "practical experience" words.

The only redeeming feature I'd give the stuff is it did seem to have a somewhat interesting libidinous peak towards the end of the "experiment". Somewhat interesting but MPA makes you cum for several minutes straight (if you can get past the vasoconstriction) at similar intervals and at least provides some actual stimulation in the meantime. If you're gonna imbibe shite at least imbibe shite with minute+ orgasm potential sez I.
 
Shambles said:
Your "actual knowledge" words sounds about spot on to me with my "practical experience" words.

The only redeeming feature I'd give the stuff is it did seem to have a somewhat interesting libidinous peak towards the end of the "experiment". Somewhat interesting but MPA makes you cum for several minutes straight (if you can get past the vasoconstriction) at similar intervals and at least provides some actual stimulation in the meantime. If you're gonna imbibe shite at least imbibe shite with minute+ orgasm potential sez I.
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The DA:SE:NE ratio is vital in defining the abuse profile/fun potential of any drug.
Coke isn't exactly ultra potent, or selective as DRA, but its moderate NE activity plus slight SRI properties give that certain 'flavour' of DA-euphoria that, whilst MA/PV compete, just can't be beaten.
 
F.U.B.A.R. said:
Wtf???

Edit: 3fpm is the tits.....
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I can't accurately describe 3-FPM.
I will consume the entire bag every time, but have little idea why.
Fuckin' with DA reward systems leads to some odd behaviour.

Also, I'm in the 'subjectively SRI-esque, but predominant DNRI feeling' camp, though ligand data states otherwise.

On the X-XPM subject; has anyone sampled other positional or substituted analogues?
3-CPM may be interesting. As does 4-MPM.
Though 'para-chloro' seems to be a death-knell for any research, given we got a Chemical Weapon and not a stimulant, when Halo-Amps were novel.
 
SproutOnSmack said:
The DA:SE:NE ratio is vital in defining the abuse profile/fun potential of any drug.
Coke isn't exactly ultra potent, or selective as DRA, but its moderate NE activity plus slight SRI properties give that certain 'flavour' of DA-euphoria that, whilst MA/PV compete, just can't be beaten.
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Just to say that I'd take meth and/or peevee over coke any day of the week...
 
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whats the crack with shooting up ethylphenidate? Is it a decent rush? (just curious.....i don't do needles)


apparently (from reliable sources) its rife around my area.

Its being sold via headshops under all sorts of stupid names, but folk spiking it up has become a bit of an issue.
 
Put it this way: my nose has been exposed to both EPD and NaOCl (s).
EPD only just came second on the pain scale.

Now imagine that in your veins.

Then there's the mannitol/lidocaine/dried spunk added into 'headshop mixes'....
 
SproutOnSmack said:
Put it this way: my nose has been exposed to both EPD and NaOCl (s).
EPD only just came second on the pain scale.

Now imagine that in your veins.

Then there's the mannitol/lidocaine/dried spunk added into 'headshop mixes'....
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Thats kinda my thoughts but allegedly the IV high is immense.

Try some 2cb or other 2c's up the beak.

new levels of pain got created for that experience
 
Shambles said:
Anyone else sampled Amfonelic acid (AFA; WIN 25,978) yet?
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Wiki says it's just a DRI, while dopamine is the euphoric part of the serotonin:dopamine:norepinephrine ratio, purely dopaminergic sdrugs (like Alzheimers drugs etc) tend to not produce any sort of euphoria and just create deliriant like hallucinations at high doses, and mania at lower doses.

It could make a nice combiner though, with an SRI like MDAI or 5-IAI, or with a straight up NRI like Pseudoephedrine even.
 
SproutOnSmack said:
I can't accurately describe 3-FPM.
I will consume the entire bag every time, but have little idea why.
Fuckin' with DA reward systems leads to some odd behaviour.

Also, I'm in the 'subjectively SRI-esque, but predominant DNRI feeling' camp, though ligand data states otherwise.

On the X-XPM subject; has anyone sampled other positional or substituted analogues?
3-CPM may be interesting. As does 4-MPM.
Though 'para-chloro' seems to be a death-knell for any research, given we got a Chemical Weapon and not a stimulant, when Halo-Amps were novel.
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This is exactly why I just got rid of my 3-FPM. I found myself using it compulsively without really knowing why.
 
swedger77 said:
whats the crack with shooting up ethylphenidate? Is it a decent rush? (just curious.....i don't do needles)
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Not such a great idea that one - EPH is ridiculously heavy on the vasoconstriction via any ROA so IV would be a hiding to nothing. As I recall (back when I had veins to kill off for research purposes) it really wasn't worth the faff given it does what it does more or less identically via any ROA. Some stims are (arguably) worth wrecking your veins for but EPH is waaaaaaay down near the bottom of my personal list.
 
patsy said:
I don't usually tale stims unless I have benzos on hand but fuck me me I tried a g of EPH whist watching the european cup final 2 years back and I swear to fuck I was ready to phone an ambulance. Hands down the worst stim I've ever tried. I don't understand why anyone just wouldn't but a proper stim. My heart felt like it was gong to explode. I'd to go out and buy a shit load of cheap strong cider to take the edge off. I felt so so toxic it was unreal.
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Strangely, both methylphenidate and ethylphenidate behave differently to other stimulant drugs when taken at high doses and don't appear to increase the likelihood of a heart attack or stroke. Methylphenidate is very well understood and, because adults drink, so is ethylphenidate because Ritalin and friends are the most over-prescribed drugs on earth. The pharmaceutical industry took a fairly rare condition and expanded its definition so far that ordinary naughtiness, boredom and rebellion became an illness requiring medical treatment involving drugs in a class known to drive people mad. At the end of 2013 20% of boys between 10 and 17 in the US had been diagnosed with ADHD and two thirds were medicated. A condition which traditionally was diagnosed in 4 out of 100 children became diagnosed in nearly 18%. Luckily for you, all the evidence gathered from the ludicrous over-prescribing of methylphenidate et al suggests your heart was probably not going to explode.
 
I'm curious to know why our government were so quick to ban phenazepam yet are reluctant to take any action on the ever increasing numbers of RC benzos. I realise (through personal experience) that phenazepam has the ability to fuck yer life up in a very short space of time, but all benzos have an insidious side. So whats going on?
 
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