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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

New (and less new) RCs - Alphabet Soup

200-250 was my usual range for 'full effects', 360mg was my intentional max. dose and that was too much.
Accidentally ingested 520mg on one occasion - physically brutal, but not lethal. NEVER dose that high.

The DRC is fairly linear up to around 160-180mg, from there upwards, the curve sharpens quickly.

I always thought of it as aMT's demonic, and much more serious, partner.
 
What's the lowdown on RC benzos atm? Was always a fan of etizolam previously, only ever use benzos for getting to sleep and comedowns tbh

Should be noted that 1mg etiz is more than enough for me
 
Etizolam seem to be getting harder to find, they're worried it might start to be seen as a 'prescription only medicine' rather than an RC because it's prescribed in other EU countries.
 
Anyone else sampled Amfonelic acid (AFA; WIN 25,978) yet? Recently become available from "The EU" and apparently soon to hit UK vendors too. The wiki page makes it sound like the absolute shit but gotta say I found it to just be absolute shit. I worked my way through 250mg over a couple days and only came within sniffing distance of anything resembling recreational effects once for a few seconds. Given it also apparently has antibiotic properties I'm calling this as an outright fail to be avoided already. Very much a case of "looks good on paper, absolute dogshit in practice" it seems.

At best, being generous, I'd maybe say it could possibly have some "functional" value but even then it's so fukkin mild you'd barely notice even if you looked. Actual noted effects were mainly none with occasional glimmers of "maybe if I concentrate really, really hard". In fairness, very few peripheral or undesirable effects either. In fact I'd go so far as to say the complete absence of activity was the overriding (lack of) feature.

Add in the utterly insane price of the stuff and it can go whistle. On it's own. In the dark. Facing the corner. In shame.
 
inflorescence said:
Does anyone actually rate 3-MMC out of interest?
Click to expand...

It's a decent drug, but it's not even close to meph.

I wound up flushing mine, and it had nothing to do with the effects of the drug. It was the fucking smell.

I did maybe two doses one evening. Next day I wake up, and I fucking stink, like I had starred in a bukkake video.

Okay, the smell is just in my nose, I think. I take a shower. Leave the house. Come back, hits me like a dump truck. Bedsheets had to be washed. Entire bathroom sprayed down and cleaned. Everything it had touched was just reeking. Never had a smellier cathinone around in my life.

1g of 3-MMC smelled up a greater percent of my house than half of a kilo of methylone and mephedrone did a few years back when I left them out overnight.

It was incredible the smell emanating from that little bag. I couldn't handle it. It was somehow way more semen - ish than cat-piss. I can take the cat-piss smell. I can never smell 3-MMC again.
 
Shambles said:
Anyone else sampled Amfonelic acid (AFA; WIN 25,978) yet? Recently become available from "The EU" and apparently soon to hit UK vendors too. The wiki page makes it sound like the absolute shit but gotta say I found it to just be absolute shit. I worked my way through 250mg over a couple days and only came within sniffing distance of anything resembling recreational effects once for a few seconds. Given it also apparently has antibiotic properties I'm calling this as an outright fail to be avoided already. Very much a case of "looks good on paper, absolute dogshit in practice" it seems.

At best, being generous, I'd maybe say it could possibly have some "functional" value but even then it's so fukkin mild you'd barely notice even if you looked. Actual noted effects were mainly none with occasional glimmers of "maybe if I concentrate really, really hard". In fairness, very few peripheral or undesirable effects either. In fact I'd go so far as to say the complete absence of activity was the overriding (lack of) feature.

Add in the utterly insane price of the stuff and it can go whistle. On it's own. In the dark. Facing the corner. In shame.
Click to expand...

Disregarding being an AB and the massive issues that brings to the table, ultra-selective DRI's are usually tosh.
Plus, the purported potentiation of, antagonists of D1/2/3/4 AND 5HT-1/2A, not to mention σ sites, typical AP's worries me....

A question: as a supposed USDRI, is it possible that the inhibition is so rapid and complete that the DA system, and thus flow of Dopamine, grinds to a near halt?
If little/no DA is present, complete blockade of reuptake proteins would produce little physiological effects, at least in the manner assumed on this board. The activity at NET being roughly zero would render no 'speedy', subjectively stimulating, effects.

To surmise; an all-but-damp squib as a recreational psychotropic, rather; an anti-biotic, anti-psychotic that adds weight to the 'DA selectivity without NE activity renders DrugX undesirable' notion.
 
JBrandon said:
It's a decent drug, but it's not even close to meph.

I wound up flushing mine, and it had nothing to do with the effects of the drug. It was the fucking smell.

I did maybe two doses one evening. Next day I wake up, and I fucking stink, like I had starred in a bukkake video.

Okay, the smell is just in my nose, I think. I take a shower. Leave the house. Come back, hits me like a dump truck. Bedsheets had to be washed. Entire bathroom sprayed down and cleaned. Everything it had touched was just reeking. Never had a smellier cathinone around in my life.

1g of 3-MMC smelled up a greater percent of my house than half of a kilo of methylone and mephedrone did a few years back when I left them out overnight.

It was incredible the smell emanating from that little bag. I couldn't handle it. It was somehow way more semen - ish than cat-piss. I can take the cat-piss smell. I can never smell 3-MMC again.
Click to expand...

Lol nasty
 
JBrandon said:
It's a decent drug, but it's not even close to meph.

I wound up flushing mine, and it had nothing to do with the effects of the drug. It was the fucking smell.

I did maybe two doses one evening. Next day I wake up, and I fucking stink, like I had starred in a bukkake video.

Okay, the smell is just in my nose, I think. I take a shower. Leave the house. Come back, hits me like a dump truck. Bedsheets had to be washed. Entire bathroom sprayed down and cleaned. Everything it had touched was just reeking. Never had a smellier cathinone around in my life.

1g of 3-MMC smelled up a greater percent of my house than half of a kilo of methylone and mephedrone did a few years back when I left them out overnight.

It was incredible the smell emanating from that little bag. I couldn't handle it. It was somehow way more semen - ish than cat-piss. I can take the cat-piss smell. I can never smell 3-MMC again.
Click to expand...

wasnt there a guy on here that said he abused this for a couple of years and it gave him permanent heart valve damage? perohaps a bit generic and might be the serotoninergic abuse and not a particular chem but still something to keep in mind
 
MrPorter said:
What's the lowdown on RC benzos atm? Was always a fan of etizolam previously, only ever use benzos for getting to sleep and comedowns tbh

Should be noted that 1mg etiz is more than enough for me
Click to expand...


It's the 'RC GABA-ergic'-era right now, IMO.
Similar to the Cathinone (4-MMC) era, the 'what shite can we shift as long as we keep " PV " in the name, the (stupidly named) benzofuran craze....

Etiz is (pretty much) gone due to the dodgy 'controlled pharm in some countries', thus admission/suggestion of human consumption, along with the legislation issues surrounding selling a patented pharmaceutical....

A real 'whoopsee' moment for the RC suppliers/Chinese Pharm. slaves/Industrial Business(wo)men.

Apologies for the OT detour, the 'lowdown' is a vast pharmacopoeia of benzo/thienodiazepines.
The results of the "if we de/halogenate X1, is the X2 product possible to sell?" notion can be seen in Diclazepam, Flubromazepam amongst others.
Flubromazolam (LAM not to be confused with PAM) is a rather new, potent, hard hitting analogue (triazo-ring-sub) F-PAM.
Pyrazolam is also, AFAIK, the TRS Alprazolam.
Clonazolam seems popular, and potent.
The demethylated, 3-OH, isomer of Flunitrazepam is available, under the 'Nifoxipam' label (or; N-Fox). However, there is some controversy surrounding its sale.
Methyl-Clonazepam is floating around the market, but given it also shows systemic anti-helminthic properties - the dewormer/benzo combo has not reached epidemic proportions, just yet, at least.
 
kingme said:
wasnt there a guy on here that said he abused this for a couple of years and it gave him permanent heart valve damage? perohaps a bit generic and might be the serotoninergic abuse and not a particular chem but still something to keep in mind
Click to expand...

5HT-2B agonism is the major factor/attribute that contributes to the infamous cardiotoxicity of many stimulants, the major increase in S/DBmMHg and BPM aside.
As a family, the Cathinones generally exhibit(ed) less DA activity than their Amphetamine counterparts, instead their activity was mainly 5HT/serotonergic with increased NE action.
Most Cathinones, especially the alkyl substitutes, are agonists of the 2B subtype, in addition to their primary target (s), and thus are thought to be a greater cardiac stressor, ergo; more cardiotoxic, than the Amphetamines.
Anyone familiar with 4-MMC/Mephedrone can likely attest to clear negative impact on circulation - the infamous 'blue knees'.
Substitution on/at the 3-position, as in 3-MMC, also tend to exhibit greater 5HT-2B activity than other positions.

Basically; prolonged administration of 3-MMC and subsequent cardiac/aortic valve damage is to be expected.

NB: the issues with Fenfluaramine, Phentermine and 4-MAR were their beta-subtype agonism and resultant valve damage and elongation of QTi, correct?
 
SproutOnSmack said:
5HT-2B agonism is the major factor/attribute that contributes to the infamous cardiotoxicity of many stimulants, the major increase in S/DBmMHg and BPM aside.
As a family, the Cathinones generally exhibit(ed) less DA activity than their Amphetamine counterparts, instead their activity was mainly 5HT/serotonergic with increased NE action.
Most Cathinones, especially the alkyl substitutes, are agonists of the 2B subtype, in addition to their primary target (s), and thus are thought to be a greater cardiac stressor, ergo; more cardiotoxic, than the Amphetamines.
Anyone familiar with 4-MMC/Mephedrone can likely attest to clear negative impact on circulation - the infamous 'blue knees'.
Substitution on/at the 3-position, as in 3-MMC, also tend to exhibit greater 5HT-2B activity than other positions.

Basically; prolonged administration of 3-MMC and subsequent cardiac/aortic valve damage is to be expected.

NB: the issues with Fenfluaramine, Phentermine and 4-MAR were their beta-subtype agonism and resultant valve damage and elongation of QTi, correct?
Click to expand...

would you venture a guess as to which of the stims (cathinones maybe) are least likely to cause heart/valve damage? i seem to remember that 4fa was supposedly safer in this regard, but my memory might play tricks

edit: also, whats the word on 3fpm (phenmetrazine). seems not very serotoninergic in practice...
 
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kingme said:
would you venture a guess as to which of the stims (cathinones maybe) are least likely to cause heart/valve damage? I seem to remember that 4fa was supposedly safer in this regard, but my memory might play tricks
Click to expand...

4-FA is a halo-Amp, and most closely follows SAR rules of the Amphetamines, AFAIK.
Though 4-FA is a remarkable anomaly -
para-halogenation resulted in 4-CA, the weapons grade neurotoxin with a predilection for permanent annihilation of the SE system. Bromination, a la 4-BA, again resulted in a SERT-Nuke. 4-IA was another toxin, with MAOI action to boot!

I am far from qualified to even begin suggesting which of this flood of stims is less/least toxic, not least given we know ~0 about some of them.
 
Methylone seems to be alright for circulation, as cathinones go. It has shitty, residual stimulation, in my case, but I never had a problem with blue limbs. 4-FA isn't a cathinone. I haven't tried it, but I do want to, as I haven't heard any horror stories. It sounds really good.
 
The prominent VC and potential 2beta related valve damage brings BK-2CB/Amp.Psyches to mind.

As much as I love BKN, 16 hours is 'prolonged exposure' to me!
 
4-fa and 4-fma are fucking horrible sketchy stims, I would not use them again. Methylone however is much nicer.
 
I found 4-FA alright, very nice to start off with but stops working if done too much, not very re-dosable. and gets jittery
 
Napthyl subbed Methamphetamine.
Seems like HDMP-28 was but a theoretical application, because NAPA or whatever the name is looks like the Holy Grail...
 
of late mxm very nice 3 fpm fucking lush damn stuffs fucked me up a little doing it with mxe mxm etzi ab-pinaca , ab-fubinaca escaline which is fucking insane stuff best when you don't trash the house and then realize the next day just how close to impaling you self on a nasty set of very sharp set of wooden spikes :) fucking gave my self concussion same night because you just can not walk on the stuff not if the is the slightest bit of wet

mess me up a bit had a war with cannibal's and hypnotists they were coming for me must say end up a very mess up 2 weeks fucking insanely fuck but messed up big time some of the shit I've seen and well still isn't to sure what was and what wasn't real think leather faces family made a deal with a time travelling devil worshiper

its a deffo must again at some point
 
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