[NBOMe Subthread] Tolerance

[Solipsis]

Merged in thread more specifically about 25I-NBOMe.

 

[Jesusgreen]

I have been on Mescaline 400 - 600 mg the past 2 nights. Im still tripping a bit actually

I was thinking of trying out 25I-NBOME at 300-450 mikes for the first time this afternoon. Will I have too much tolerance built up from the mescaline already?

Yes you will, and 300-450ug is at the bottom end of the dose range so I wouldn't expect much from it.

I'd give it at least a week, ideally two since you already tripped two nights in a row, then give it a try

Hopefully you didn't already take it and miss out.

 

[Synaptic Gap]

Yes you will, and 300-450ug is at the bottom end of the dose range so I wouldn't expect much from it.

I'd give it at least a week, ideally two since you already tripped two nights in a row, then give it a try

Hopefully you didn't already take it and miss out.

I did end up trying the 450ug. It was very relaxing, euphoric and made everything look really pretty. It was a nice way to end a fun weekend but not a full on psychedelic experience. I liked what I felt from this substance and I will try this again in a few weeks at 800 - 1000 ug with no other psychs in my system.

 

[slo mo]

I once went through about 3mg of 25c-NBOMe trying to extend a ++ trip. It might have increased the duration but I never made it up to +++

I have had similar experience and I am glad you posted this. When this happens, one can get a bit down on the compound, when in fact it was the ROA or dose that was to blame.

 

[slo mo]

I did end up trying the 450ug. It was very relaxing, euphoric and made everything look really pretty. It was a nice way to end a fun weekend but not a full on psychedelic experience. I liked what I felt from this substance and I will try this again in a few weeks at 800 - 1000 ug with no other psychs in my system.

If you wait a few weeks and try 1mg nasal, things will look quite different than "pretty"8(
Sounds like you are ready though
enjoy

 

[correctly]

a week ago i got a 125mg order of 25i and me and 3 other people consumed it thought the day(split into 4 piles of 30 mg, with me getting an extra 5), and it was the most boring trip of my life. then next day my mind wasnt able to think worth shit and it was complicating to do the most simple tasks, but felt just fine and was ok with everything. my other friend went fishing with his dad and watched a movie and was just fine, mentally and physically. my other 2 friends said they thought they were going to loose their minds, and the next day they stayed home all day throwing up and feeling like shit. a week later i get a 10mg 25i sample from a new vendor, thinking that my last order could have been a bad batch.
i took all 10mg under my tounge at once and i was barely trippin.

the only visuals that actually satisfied me were looking at the tv, it was changing colors, twirling and looked like the screen was underwater. besides that, i knew exactly was i was going to see in my halucinations(witch made trippin on 25i boring as fuck), like looking at the pavement an i would see dots of color coming up and moving around, then i would go inside and see the carped doing a wave. then 20 minutes later i would go outside to smoke a cigarette and look at the concrete and see the same thing(little dots of color floating around).

overall 25i was a waste of killed brain cells, but how long does a 25i tolerance last?

probably the one of the dumbest things i have ever seen in bluelight. damn it. i cannot believe you. good thing you did not kill yourself AND YOUR FRIENDS with this stupidity. i hope to God what you took was not 25i. fucking retarded.

 

[klondike_bar]

a week ago i got a 125mg order of 25i and me and 3 other people consumed it thought the day(split into 4 piles of 30 mg, with me getting an extra 5), and it was the most boring trip of my life.

a week later i get a 10mg 25i sample from a new vendor, thinking that my last order could have been a bad batch. i took all 10mg under my tounge at once and i was barely trippin.

overall 25i was a waste of killed brain cells

you are an idiot. This chemical is documented as fully active at under 1mg, and there are very disasterous reports when its used at over 2-3mg. Why would you dose people at 30mg, then a week later (FROM ANOTHER BATCH) take 10mg at once!?

im surprised that there are/were braincells left to be killed.

 

[tryp2fun]

a week ago i got a 125mg order of 25i and me and 3 other people consumed it thought the day(split into 4 piles of 30 mg, with me getting an extra 5), and it was the most boring trip of my life. then next day my mind wasnt able to think worth shit and it was complicating to do the most simple tasks, but felt just fine and was ok with everything. my other friend went fishing with his dad and watched a movie and was just fine, mentally and physically. my other 2 friends said they thought they were going to loose their minds, and the next day they stayed home all day throwing up and feeling like shit. a week later i get a 10mg 25i sample from a new vendor, thinking that my last order could have been a bad batch.
i took all 10mg under my tounge at once and i was barely trippin.

the only visuals that actually satisfied me were looking at the tv, it was changing colors, twirling and looked like the screen was underwater. besides that, i knew exactly was i was going to see in my halucinations(witch made trippin on 25i boring as fuck), like looking at the pavement an i would see dots of color coming up and moving around, then i would go inside and see the carped doing a wave. then 20 minutes later i would go outside to smoke a cigarette and look at the concrete and see the same thing(little dots of color floating around).

overall 25i was a waste of killed brain cells, but how long does a 25i tolerance last?

From the description of effects, dosage, and pharmacokinetics, it looks to me that this was 2C-I, not 25I. 10 mg of 2C-I is a modest dose, but not 10 mg of 25I! 30 mg of 25I (about 60 normal 500 ug doses!) would have resulted in a trip to the hospital in the very best case. 8(

 

[Jesusgreen]

Regarding tolerance, I'm curious if people could be more detailed with their experiences with it.

With 2C-Xs, for me the tolerance works something like this:
- 1 day after my trip, need ~1.25x my previous dose for a similarly intense trip
- 3 days after my trip, need ~1.1x my previous dose
- 5 days after my trip, I'm almost baseline tolerance, unless I've been tripping regularly

With most other psychedelics, the tolerance works more like this:
- 1 day after my trip, need ~1.5x my previous dose for a similarly intense trip
- 3 days after my trip, need ~1.35x my previous dose
- 5 days after my trip, need ~1.2x my previous dose
- 7 days after my trip, pretty much baseline tolerance provided I haven't been tripping regularly

I've heard figures of needing 2 weeks break after NBOMes but I'm wondering about how the tolerance breaks down over the time. I find for example with most psychedelics, only taking 5 days is very little different from taking 7 days before your next trip - and even 3 days doesn't require much of a dose increase, but the tolerance is certainly a little noticeable.

In a similar respect I'd imagine with NBOMes that with the quoted 2 week figure that'd make 5-6 days in similar to 3 days after most other psychedelics? What have you guys experienced with it? Does the tolerance drop gradually or is it quite a sudden drop off around the 2 week mark?

Is there anyone who hasn't found NBOMes to produce long lasting tolerance like people claim they do? I seem to remember hearing a few people saying they only found the long tolerance because they were dosing the NBOMes frequently, so I'm curious as to what others have observed.

How does the dose affect the tolerance with these, if at all?

Has anyone here tripped weekly on these - if so how can you comment on how bad the tolerance got after a few weeks?

Another useful question, how many of you have found differences in the tolerance produced by each individual NBOMe - which produced the longest lasting tolerance and which the shortest? It'd be great if you added actual times too.

Interesting to hear about 25B producing shorter tolerance, I've heard similar things about 25C too, and from most reports 25I seems to be the worst but I'd like to see if others can back this up or if it's not true.

It seems most of the information we have on the tolerance of these compounds so far is a few anecdotal comments here and there - it'd be worth us all fleshing it out a bit with some more details

Edit: Something interesting I've read a few times is that while tolerance between NBOMes seems to last about two weeks, people are saying they took another psychedelic a week later with no noticeable tolerance - just as if they'd taken any other psychedelic a week prior. Does the 2 weeks really not apply to cross-tolerance? Anyone else confirm this?

 

[electric wizard]

a week ago i got a 125mg order of 25i and me and 3 other people consumed it thought the day(split into 4 piles of 30 mg, with me getting an extra 5), and it was the most boring trip of my life. then next day my mind wasnt able to think worth shit and it was complicating to do the most simple tasks, but felt just fine and was ok with everything. my other friend went fishing with his dad and watched a movie and was just fine, mentally and physically. my other 2 friends said they thought they were going to loose their minds, and the next day they stayed home all day throwing up and feeling like shit. a week later i get a 10mg 25i sample from a new vendor, thinking that my last order could have been a bad batch.
i took all 10mg under my tounge at once and i was barely trippin.

the only visuals that actually satisfied me were looking at the tv, it was changing colors, twirling and looked like the screen was underwater. besides that, i knew exactly was i was going to see in my halucinations(witch made trippin on 25i boring as fuck), like looking at the pavement an i would see dots of color coming up and moving around, then i would go inside and see the carped doing a wave. then 20 minutes later i would go outside to smoke a cigarette and look at the concrete and see the same thing(little dots of color floating around).

overall 25i was a waste of killed brain cells, but how long does a 25i tolerance last?

i experienced the same sort of trip from 25i-nbome but i enjoyed it but yes it was weaker then any acid iv done but i think it may have been due to tolerance that week i had done mushroom tea twice and 2c-b about 3 times.
i also had the dots of color visuals

1200 microgram tab i placed the tab under my tongue for 40 minutes and chewed my mouth felt a bit strange where the tab was the chemical taste
it felt very similar to lsd but different the hole trip felt weak compared to a tab of lsd. the visuals consisted of seeing small spots of purple blue green yellow and orange colors over trees, grass and beach, similar to the lingering effects of lsd after going over the peak and coming down. after 6 hours i made it home in my car and the sun was down. the visuals came back but different, just a dark colored slow flow of geometric patterns going out over the foot path, road then the grass and up the trees.
it looked very smooth and it covered everything i stared at. for some reason in the rain the patterns were much more evident anything coated in water shined with a rainbow of dark colors very beautiful other then that the trip visuals were very tame. my mate did nbome with me but he was way more fucked up and did it the previous day and said it was stronger then any acid he has had.

but i still dont understand why i didnt get as fucked up as he did. could it be due to the mushroom tea and 20mg of 2c-b i had 2 days before and a day before that a bigger jar of mushroom tea and lots of 2c-b use? im pretty sure the alkaloids in mushrooms act on the same recepters as lsd and nbome so maybe iv fried my brain to much from lsd mushrooms and 2c-b use and should take a break?

 

[RobotRipping]

the psychs you did earlier before would definitely have an impact on your tolerance, big time. 1.2mg of 25i was not a big enough dose for me personally but with no tolerance it's a decent trip. yeah these drugs act on the same receptors in slightly different ways, 25i having a huge affinity for binding at the 5ht2a site iirc. You didn't fry your brain, just space out your nbome use by 2 or more weeks. Even with your regular old psychs like the 2c-s and tryptamines, if i trip every weekend i seem to accumulate tolerance and after a few weekends i can take double the dose i first started at and get about the same trip.

 

[electric wizard]

the psychs you did earlier before would definitely have an impact on your tolerance, big time. 1.2mg of 25i was not a big enough dose for me personally but with no tolerance it's a decent trip. yeah these drugs act on the same receptors in slightly different ways, 25i having a huge affinity for binding at the 5ht2a site iirc. You didn't fry your brain, just space out your nbome use by 2 or more weeks. Even with your regular old psychs like the 2c-s and tryptamines, if i trip every weekend i seem to accumulate tolerance and after a few weekends i can take double the dose i first started at and get about the same trip.

yeah it was my first try of nbome
my brain always feels fried after using psychs

 

[RobotRipping]

yeah try 1mg after a month of not tripping at all (on any 5-ht2a psychs, tall order i know) and you'll get the full experience. My psych tolerance has always been high and i enjoyed much higher doses but can't recommend it because of too many adverse reactions being reported with 25i in particular. Either way most tryptamines and phenethylamines and related drugs that act on 5-ht2 receptor create rapid tolerance, to the point where you have to double and triple your doses if you want to trip for 2-3 days in a row. The nbomes create an even more rapid and long lasting tolerance than all other psychedelics i've tried.

if you're like me and trip a lot, you'll just end up taking higher doses and accept that other people can get more high than you at a lower dose.

tl;dr don't bother taking 25i if you've tripped at all in the last week and don't expect to trip hard on 25i if you do it often, at least a 2 week space between dosing is needed for tolerance to drop.

 

[Solipsis]

Merged threads and posts.

E_W there was absolutely no need to create a new thread, your question can be answered and discussed here, it's considered entirely within the confines of this topic.

 

[blazR]

My experience regarding tolerance to the NBOMe's are mostly the same as you guys..

I've tried taking 25I and 8 days after i took a combo of 25I and 25B. Compared to the trip 8 days before, the latter one was pretty mellow even though the doses was higher.

1 week is definately not long enough for the tolerance to drop significantly IMO.

 

[Synaesthesia242]

I have experienced cross tolerance with NBOMEs and other drugs too .. Both ways. 1 week after a very strong NBOME trip LSD and MDMA had much weaker effect. Hardly any visuals.

W also had a weekend where we were partying non stop. Took quite a bit of LSD, 2C-B and MDMA the first 2 nights. 3rd night was the NBOMEs and the experience was also much much weaker than usual. Still had some visuals but not the usual craziness.

 

[Crashing]

I found the NBOMe to sort of not get any more intense with dosage. 100ug was a +1 and then a month later 1000ug was a +1 form the same batch with more side effects. One thing i'll never do is take 30mgs though i can promise you that. Sounds like you got really lucky hopefully you dont have permanent brain damage.

 

[Synaesthesia242]

I don't know, the effects can be somewhat unpredictable. But 1000ug should have you at more than a +1. Try it again sometime, the stuff is intense.

 

[slo mo]

i experienced the same sort of trip from 25i-nbome but i enjoyed it but yes it was weaker then any acid iv done but i think it may have been due to tolerance that week i had done mushroom tea twice and 2c-b about 3 times.
i also had the dots of color visuals

1200 microgram tab i placed the tab under my tongue for 40 minutes and chewed my mouth felt a bit strange where the tab was the chemical taste
it felt very similar to lsd but different the hole trip felt weak compared to a tab of lsd. the visuals consisted of seeing small spots of purple blue green yellow and orange colors over trees, grass and beach, similar to the lingering effects of lsd after going over the peak and coming down. after 6 hours i made it home in my car and the sun was down. the visuals came back but different, just a dark colored slow flow of geometric patterns going out over the foot path, road then the grass and up the trees.
it looked very smooth and it covered everything i stared at. for some reason in the rain the patterns were much more evident anything coated in water shined with a rainbow of dark colors very beautiful other then that the trip visuals were very tame. my mate did nbome with me but he was way more fucked up and did it the previous day and said it was stronger then any acid he has had.

but i still dont understand why i didnt get as fucked up as he did. could it be due to the mushroom tea and 20mg of 2c-b i had 2 days before and a day before that a bigger jar of mushroom tea and lots of 2c-b use? im pretty sure the alkaloids in mushrooms act on the same recepters as lsd and nbome so maybe iv fried my brain to much from lsd mushrooms and 2c-b use and should take a break?

Just take a 2 week break. Taking shrooms consecutive days created a tolerance and be careful next time you trip . If you had the 1200ug tab with no tolerance it should be quite different so be careful .

 

[ebola?]

From collected anecdotes that people have seen, what if someone were to take a low 'tester dose' (just above threshold) of one of these compounds (say...~250 mics), and deem it an undershot...how marked and enduring should tolerance to the compound (and similarly acting psychedelics) be?

I'd expect something between (non-inclusive) the enduring, dramatic tolerance seen with strong doses and a complete lack of tolerance...but what, in particular, should we expect along this spectrum?

ebola