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N-methyl-1-(thiophen-2-yl)propan-2-amine/MPA

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I think a previous vendor set a good example with their handling of the distribution of O-desmethyltramadol. It comes down to two things - price and and ease of access. If the quantities stay small and the availability is inconsistent then it is much more difficult for it to blossom into an meph-style craze. Also I think everyone is jumping the gun on this, are we really so certain it will have the same abuse potential as meth? So many simple substituted amphetamines have been available I don't see why this one would be any more problematic than, say, methylone.
 
The difference is o-desmethyltramadol isn't an obvious analog of the most publicly vilified drug out there

Whatever activity and toxicity this compound shows notwithstanding, the structural similarity alone is enough to bring on the previously mentioned shitstorm...
 
I've never been one for Meth and wouldn't touch this new RC with a ten foot pole, But I am really interested in how the Phenyl group being replaced with the ring with sulfur in it effects the activity. Would love to hear a trip report.
 
They'll probably be coming out with the naphthyl analogue of meth next :\

Honestly, has any drug ever been improved by replacement of a phenyl ring with another aromatic system? (obv excluding indole psychedelics)
 
I honestly think that those individuals who received the samples should think long and hard before posting reports. This really needs to stay hush hush.
 
the outsider said:
They'll probably be coming out with the naphthyl analogue of meth next :\

Honestly, has any drug ever been improved by replacement of a phenyl ring with another aromatic system? (obv excluding indole psychedelics)
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I'm just waiting for us to see the coronenyl analogue of amphetamine - I called it cancerodrone ;)

pahamp.png
 
Experience reports have been posted (on here and elsewhere) for both this thiophene methamphetamine analogue, and also its primary amine and beta ketone analogues.

They are apparently weaker than the corresponding amphetamines and produce nasty high blood pressure and vasoconstriction as side effects, though the beta ketone derivative is said to be not so bad for this as the other two.

The analogue of meth where the phenyl has been replaced by pyridin-3-yl has also allegedly been tested, and again is active but weaker than the parent amphetamine.
 
pofacedhoe said:
i have a feeling the reality is that the trip reports are not going to be wholesome and positive...
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not seen any recently but the russian speaking site had a few a while back for the primary amine which were not very promising. the N-methylated compound may be radically better possibly I doubt it.
 
If anyone thinks it's that simple as "thiophen-2-yl > phenyl", then why not:
1-(furan-2-yl)-N-methylpropan-2-amine...
 
I think the 2-furyl compound has been made... IIRC, it was tested in rabbit bioassays some time ago... I think it was an active stimulant but had some side effects, can't remember what.

Disclaimer: I just vaguely remember hearing this in BL some time ago, so I don't know if this is correct...
 
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It sure was ironic. Let's look at amphetamines and say that they're compounds with very simple structure. The fact that thiophen-2-yl or furan-2-yl are groups that increase potency of some drug doesn't mean they will work the same way here... I wrote "furan-2-yl" because 2-(furan-2-yl)ethyl is better than phenylethyl on nitrogen in e.g. levorphanol. But firstable it's an opioid, and secondable its metabolism is completely different. Having phenyl ring in amphetamines makes metabolism easier, as making a molecule more hydrophilic is one way of metabolism, hydroxy groups are attached where possible (and this makes another step possible - conjugation). N-methyl-1-(thiophen-2-yl)propan-2-amine and 1-(furan-2-yl)-N-methylpropan-2-amine would be metabolized differently. And one can bet this changes their effects as it makes their pharmacokinetics different from methamphetamine for sure.

And let's say there are free samples of both drugs. I wonder who'd be the first to take them... It wouldn't be me certainly. Luckily I'm not into stimulants so I don't need this mission to find methamphetamine replacement.
 
in a word shit in the shit a little advice if I can allow myself to keep your money for something else!!
 
the outsider said:
They'll probably be coming out with the naphthyl analogue of meth next :\

Honestly, has any drug ever been improved by replacement of a phenyl ring with another aromatic system? (obv excluding indole psychedelics)
Click to expand...

well, I suppose it depends upon what you mean by improved. With several morphinan opioids an N-furethyl can cause a greater increase in potency versus N-phenethyl. I think that is the case with levorphanol, where the N-furethyl is like 45X as potent as levorphanol (N-methyl) If you replace the 2-furan, with a thienyl it is about 30X levorphanol but with a phenyl it's like 15X. I think this is a bit more dramatic than most other examples of the same phenomena. Of course levorphanol is already pretty potent so I'm not sure if that is an improvement.

I think in the majority of cases with full mu agonist N-aromatic-ethyl substituents phenethyl is the most potent with the phenanthrene opioids but with levorphanol based structures it seems to not be the case. For some reason I want to say thiofentanyl (N-(2-thienyl)ethyl) is also more potent than regular fentanyl (N-phenethyl) but I can't say why I think that. This of course again if you're assuming more potent equals better.

As for other examples in opioids outside of the N-phenethyl substituent with phenanthrene alkaloids, with the thiambutenes if you asymmetrically replace one of the thienyl rings with a phenyl you get almost no activity, and if you replace both with a phenyl you get a substantial decrease (60-90% ) in potency. Oddly, with the methadone drugs it is the opposite. One phenyl and one thienyl ring equals little to no activity and two thienyl rings there's a substantial reduction.
 
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