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N-methyl-1-(thiophen-2-yl)propan-2-amine/MPA

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Like a weak dextroamphetamine, shorter duration that dextro- and meth-, nice mood lifter on the level of Ritalin, little comedown, effects vary according to ROA. Seems smokers and bootir-bumpers egt the best results, few complaints of vassoconstriction, has nothing to do with meth!!
 
Do you think adding something to the ring might improve this, say a methyl at the 4th or 5th position or removing the N-methyl?
 
Adding a 5-methyl to MPA would likely produce a compound with some kind of serious activity.
 
^ Yeah, but he's not wrong. I believe he's talking about N-methyl-1-(5-methylthiophen-2-yl)propan-2-amine, which I'm pretty sure is proper IUPAC for the compound he's talking about.
 
Hammilton said:
^ Yeah, but he's not wrong. I believe he's talking about N-methyl-1-(5-methylthiophen-2-yl)propan-2-amine, which I'm pretty sure is proper IUPAC for the compound he's talking about.
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Anything more you can ad? Is the above poster correct about it's activity?
 
dread said:
I'm just waiting for us to see the coronenyl analogue of amphetamine - I called it cancerodrone ;)

pahamp.png
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I raise you this:

Buckyball.png


I call it, buckminsteramfulleramine.
 
fryingsquirrel said:
Anything more you can ad? Is the above poster correct about it's activity?
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About what Synapse had to say? He didn't offer any suggestions about activity...

5-Me-MPA? I wouldn't take it. And I really definitely wouldn't take it without seeing some sort of assay first. I'd be concerned about whether it's a 5HT releaser and or 5HT2b agonist- both of which are reasonably likely (I'd say 70% and 50% odds, respectively for the given actions) in my mind.

People always want a 5HT releasing drug- they're more enjoyable than simple DA releasing or reuptake inhibiting drugs- but they're also way more dangerous. 5HT release combined with DA release makes for neurotoxicity- selective 5HT releasers on their own aren't neurotoxic (MDAI, for obvious instance) but become so when they start releasing DA too.

Whether it's a 5HT2b agonist is hard to say, but an x-alkyl-thiophene would presumably be more likely than an unsubstituted thiophene.

Just my thoughts...
 
Yes, "easy to make" [like money] is relative. It also depends a lot on the available precursors at a given time, of course.
 
These amphetamine analogues are going to lead to something nasty like that older more known amphetamine analogue (i cannot think of the name now) patients that used it or tested it started to get parkinsons like movement disorders a decade later
 
i read it on bluelight a long time ago, a moderator wrote about it.
i cant seem to search bluelight everything says no matches found
 
lagger said:
These amphetamine analogues are going to lead to something nasty like that older more known amphetamine analogue (i cannot think of the name now) patients that used it or tested it started to get parkinsons like movement disorders a decade later
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You're talking about MPTP, which was a pethidine derivative and caused a Parkinson's-like condition more or less immediately. That's a lot of things to get wrong in one sentence. You can't find it because you've remembered it so inaccurately.

That said, I still like how you make this rather extraordinary claim without feeling the need to explain it at all, as if it were an obvious fact.

There's absolutely no reason to believe that this is true, though it would have been interesting to see what convoluted logic was used to get to that point.
 
p-chloroamphetamine (PCA) may have wiped out users' serotonin, but it didn't cause Parkinson's I don't think.
 
^^^
No pCA does not cause parkinsonism, as the symptoms are mediated by DA not 5HT.

EDIT: MPA is quite an impressive substance, in a going-to-the-library-and-reading-a-book way. I wonder about replacing the thiophene ring with a dithiolane ring, this occurred to me while taking R-lipoic acid to prevent the potential serotonergic neurotoxicity.
 
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