My AntiAging-Cognitive Regimen

[spaceyourbass]

A healthy body is pretty damn resilient by itself. No one needs to take that many supplements. The key to living long is to exercise and live stress free, and of course a good diet and a few vitimans here and there don't hurt. Taking that many things has to be expensive and time-consuming. If doing that relieves your stress there is possibly a psychological thing you should get checked out.

 

[IlostaMadge]

A very informative topic, it's good to see so much interest in this area, and whilst you seem very well educated, your stack must require a small vehicle to transport.

My knowledge of this area is fairly dire, but I'll bring up a few points/questions.

R-Lipoic Acid (from na-rala/rala/rmct/sr) 450 mg

Thats a hefty dose, it might be counter productive, not too mention unnecessary given the amount of anti oxidants in your stack, although I understand it can "recycle" some other AO's.

Trans-Resveratrol 250 mg (w/f)
Melatonin 1 mg (w/f)

Is the trans isomer significantly different to racemic? You do know Resveratrol reduces the effectiveness of telomerase activators don't you?
Melatonin is something I would love to know more about, it has huge affinity for various receptors that regulate the immune system doesn't it?

Centrophenoxine 500 mg (w/f)

I found high doses made me slightly twitchy and irritable, have you ever experienced this?

I can't see MG+ anywhere on there, I found that to have a nice cognitive boost.

I would of thought the deprenyl and PEA would be rather nasty together, certainly that dose, the subsequent free radical release (deprenyl at that dose won't really inhibit the beakdown that much I think) could pose a threat, although you take decent anti oxidants.

I don't want to ignorantly presume anything, but there are a lot of compounds there, the combined effect on your metabolic pathways and enzyme levels must do something, have you noticed any metabolic changes?
I can see your diet is good, I'm assuming you don't go near anything that could inhibit the absorption of your stack?

I was under the impression TA's were rather new and unresearched and potentially cancer promoting?

What are your thoughts with regards to receptor function and desensitivity, have you noticed any mood changes?

Yeah, excessive acetylcholine, as is seen in cases involving cholinerserase inhibitors, can cause the person to experience irrational amounts of extreme rage due to it's effects in the amygdala - several placid people have killed for utter petty reasons (one case I can think of was because a pest controller who'd been accidentally exposed was hasving a piss against a fence. A woman came out to have a word with him and he beat her to death. This was someone described as one of the most placid people you'd ever wish to meet) because of excessive acetylcholine levels due to cholinesterase inhibition.

I used to take L Dopa infrequently, I went from a placid person to breaking 3 knuckles on a computer monitor because someone had the unmittigated audacity to read an msn conversation over my shoulder.

I no longer take L Dopa, and no matter how pumped or aggressive I feel, I have learnt that crt monitors do not shatter spectacularly when struck.

What form do you take your supplements in, if you use caps/powder theres a lot of filler going through your system, which can't be at all beneficial?

Have you ever taken a supplement that was later revealed to be potentially harmful?

What are your views/actions concerning things like substance P and the damage they can wreak on the body? I think pyschological state has a direct consequence on health, and maintaining a stress free, happy, productive lifestyle would be essential to get the most out of your stack.

I apologise for any ignorance in this post. This thread has been really informative, I have a lot to learn.

Do you take any Dopamine or Serotonin precursors?

Do you monitor your BP/Pulse regularly, the PEA/Deprenyl causes some rather alarming changes in some people.

In my eyes (think junky) GBL/GHB would be a worthy addition to that stack, it would also promote liver function. Do you take any testosterone regulators for muscle maintanence etc?

Do you ever take recreational drugs? I am guessing as an MD you are not able to.

Anyway, good luck with your stack. I'll leave you with possibly the most patronising condescending line I can think of: -

"The moutains in the distance pale in comparison to the flowers at your feet."

I am sorry about the length, general rambling and spelling mistakes, I am rather burnt out after an incredibly stupid desoxypipradrol session.

Do you know much about astragloside? I think it works on telomeres, and has been shown to promote lab animal lifespan.

I meant to ask, are you an abolitionist by any chance? If so, have you written anything on the subject?

 

[NeuronalPerception]

in my experience, mucking about with the acetylcholine axis (the major neurotransmitter most popular nootropics target) can do more damage than good.

Remember some of these nootropics (piracetam and potent choline donators in particular) can produce very strong effects that may knock your regular thought processes/cognitive stability completely out of whack.

Also there is very little long-term research on lots of these compounds. Drug interactions in particular (with psychedelics and empathogens) is really an unknown territory still.

Proceed with caution.

Nootropics are not for everyone as everyone's neurochemistry is different.
I don't use psychedelics and empathogens. Nor would recommend them.

 

[NeuronalPerception]

My wife works for poisons unit and is frequently appalled at the lack of pharmacological knowledge doctors & even a fair few consultants have, so it's far from any guarentee that doctors will have any better knowledge of pharmcology/pharmacokinetics than a well read layman (as I've discovered first hand of at least 2GPs at the practice I attend).

As a rule, doctors take a lot of their pharmacological knowledge from pharmaceurical reps who try to get them to prescribe their drugs - not exactly known for their impartial attitude, esp to drugs not produced by their firm




As it has vasopressor activity, I can't see how massive doses taken in order to try (pretty unsucessfully) can fit into any healthy regeime either. I'm far from mr healthy living, but I wouldn't even consider trying to eat several grams of PEA every day for an effect that very small doses of selegeline can achieve (which also protects your brain from oxidative stress from enviromental toxins etc. It also pritects against Parkinsons from crap in the enviroment thaty acts in the same way MPTP does, which is more tham PEA does)




Yeah, excessive acetylcholine, as is seen in cases involving cholinerserase inhibitors, can cause the person to experience irrational amounts of extreme rage due to it's effects in the amygdala - several placid people have killed for utter petty reasons (one case I can think of was because a pest controller who'd been accidentally exposed was hasving a piss against a fence. A woman came out to have a word with him and he beat her to death. This was someone described as one of the most placid people you'd ever wish to meet) because of excessive acetylcholine levels due to cholinesterase inhibition.

That's beside all of the drooling cholinergic drugs like arecoline stimulate!

I don't use phenylethylamine.

 

[NeuronalPerception]

When humans become more obsessed with extending their lifespan then living the life they have you gotta know we have an overdeveloped consciousness.

i bet you could surpass all those supplements and their effects if you just decided to live as happily as you could, im sure all the money youd save on those would go a long way!

My cost of supplements is minor compared to what I spend on organic produce.

 

[NeuronalPerception]

A healthy body is pretty damn resilient by itself. No one needs to take that many supplements. The key to living long is to exercise and live stress free, and of course a good diet and a few vitimans here and there don't hurt. Taking that many things has to be expensive and time-consuming. If doing that relieves your stress there is possibly a psychological thing you should get checked out.

No one needs to take anything and I do have not any stress condition.

 

[NeuronalPerception]

A very informative topic, it's good to see so much interest in this area, and whilst you seem very well educated, your stack must require a small vehicle to transport.

My knowledge of this area is fairly dire, but I'll bring up a few points/questions.

Thats a hefty dose, it might be counter productive, not too mention unnecessary given the amount of anti oxidants in your stack, although I understand it can "recycle" some other AO's.

My measure of oxidative stress shows no increase.

Is the trans isomer significantly different to racemic? You do know Resveratrol reduces the effectiveness of telomerase activators don't you?
Melatonin is something I would love to know more about, it has huge affinity for various receptors that regulate the immune system doesn't it?

I found high doses made me slightly twitchy and irritable, have you ever experienced this?

It's present in my wine and a few supplements so alittle hard to avoid. I'm not too concerned at the dose.
Melatonin effects several systems. I have not noticed any problems at my current dose and have not found the need to go higher.

I can't see MG+ anywhere on there, I found that to have a nice cognitive boost.

I get plenty of magnesium.

I would of thought the deprenyl and PEA would be rather nasty together, certainly that dose, the subsequent free radical release (deprenyl at that dose won't really inhibit the beakdown that much I think) could pose a threat, although you take decent anti oxidants.

I don't use phenylethylamine. Have no reason to try it.

I don't want to ignorantly presume anything, but there are a lot of compounds there, the combined effect on your metabolic pathways and enzyme levels must do something, have you noticed any metabolic changes?
I can see your diet is good, I'm assuming you don't go near anything that could inhibit the absorption of your stack?

Blood testing and other tests show no impairment.

I was under the impression TA's were rather new and unresearched and potentially cancer promoting?

TA's?

What are your thoughts with regards to receptor function and desensitivity, have you noticed any mood changes?

Pertaining to which compounds? My mood is not irrevent but I do not have any mental illness.

I used to take L Dopa infrequently, I went from a placid person to breaking 3 knuckles on a computer monitor because someone had the unmittigated audacity to read an msn conversation over my shoulder.

I no longer take L Dopa, and no matter how pumped or aggressive I feel, I have learnt that crt monitors do not shatter spectacularly when struck.

Why would you take L-DOPA?

What form do you take your supplements in, if you use caps/powder theres a lot of filler going through your system, which can't be at all beneficial?

Mostly pure powder.

Have you ever taken a supplement that was later revealed to be potentially harmful?

Science changes daily however nothing I've taken showed any serious concern.

What are your views/actions concerning things like substance P and the damage they can wreak on the body? I think pyschological state has a direct consequence on health, and maintaining a stress free, happy, productive lifestyle would be essential to get the most out of your stack.

They can. Aprepitant and related drugs are of interest to me for this purpose.

I apologise for any ignorance in this post. This thread has been really informative, I have a lot to learn.

Accepted and your welcome.

Do you take any Dopamine or Serotonin precursors?

I rarely find them needed.

Do you monitor your BP/Pulse regularly, the PEA/Deprenyl causes some rather alarming changes in some people

In my eyes (think junky) GBL/GHB would be a worthy addition to that stack, it would also promote liver function. Do you take any testosterone regulators for muscle maintanence etc?

I run several tests daily. PEA and deprenyl can cause severe changes in blood pressure.
My hormones are normal for my age so no not at this time.

Do you ever take recreational drugs? I am guessing as an MD you are not able to.

Have little reason to.

Anyway, good luck with your stack. I'll leave you with possibly the most patronising condescending line I can think of: -

"The moutains in the distance pale in comparison to the flowers at your feet."

I am sorry about the length, general rambling and spelling mistakes, I am rather burnt out after an incredibly stupid desoxypipradrol session.

Do you know much about astragloside? I think it works on telomeres, and has been shown to promote lab animal lifespan.

Have not heard of it.

I meant to ask, are you an abolitionist by any chance? If so, have you written anything on the subject?

No.

 

[mariacallas]

*bump*

 

[acantelopepope]

I just read this entire thread... What was the original stack?!

 

[dokomo]

Seriously, does anyone have the original list?

 

[Transcendence]

I think the updated list is an improvement.

 

[p-mo]

I just read this entire thread... What was the original stack?!

It was like half a page of every vitiman, mineral, herbal and nutritional supplement known to man.