My AntiAging-Cognitive Regimen

[p-mo]

This is OCD if ever I've seen it... do you scrub your entire house with antibactirial spray?

 

[NeuronalPerception]

Exactly my point. it doesn't extend the telomeres, it just reduces the rate at which they are degraded. Your title 'telomere lengtheners' is VERY misleading. Telomeres cannot be lengthened by any known mechanism in mammals because there is no native enzyme that can do it. Period. I've heard that certain types of cancerous cells can extend their own telomeres, but that's of no use to a living organism.

Interesting study though. Are there others, perhaps of the in-vivo variety? I personally don't like basing my supplement regimen on a single, in-vitro study, but different strokes for different folks as they say.

telemorase extends telemeres. As does TA-65. My title is how I chose to view it. Carnosine has many other proven antiaging effects based on many studies but it seems you are unfamiliar with them.

 

[NeuronalPerception]

its in high doses that it seems to have a much better effect, i find it pretty unusual that you dont wonna take resveratrol right now but do mix so many sups when its interactions are unknown

It does not interest me at the moment. We'll see.

 

[NeuronalPerception]

how much would using the items on your list cost a month?

Hard to say. I'll do a review.

 

[NeuronalPerception]

If you are taking sups that affect your mind/body, how you feel is of absolute importance in my eyes. Why did you even post this list if you won't comment on what the sups are actually doing?

Also, how can you so easily assume that mixing all of this stuff doesn't change each compounds' intended effects? You obviously know a lot about the subject and I'm very curious.

One other thing...you kind of come off as a condescending, argumentative, know-it-all in this thread. Maybe you don't care about interpersonal/physical relationships, but imo (and this is backed by loads of psychological research) having close bonds with other humans and animals is essential to both life quality and quantity. ..i do realize this is a single internet thread and not your entire life.

peace

I don't understand your first question. If you don't know what a compound is or what it does then research it.

I do extensive blood testing and notes as I add any compound to my list. I also time when I take them so there is little unexpected interaction. There are always some risk however when death and disease is on the line I feel fine taking what i take.

I don't know everything in life, However I am quite aware of the compounds I take and various aging processes.

 

[NeuronalPerception]

excellent thread!!!

Thank you.

 

[NeuronalPerception]

This is OCD if ever I've seen it... do you scrub your entire house with antibactirial spray?

I don't have OCD I simply have the time, money, and knowledge to greatly reduce my aging process. My house is clean so I don't have a need for any spray.

 

[Dave]

telemorase extends telemeres. As does TA-65. My title is how I chose to view it. Carnosine has many other proven antiaging effects based on many studies but it seems you are unfamiliar with them.

a) I've never heard of TA-65, what is it?
b) Telomerase is only expressed (in mammals) in stem cells and certain cells that reproduce often (ie. immune system cells). Somatic cells have virtually no telomerase expression. Source. Do you have an abstract handy that shows that carnosine promotes telomerase expression? Otherwise I stand by my previous statement: reducing the rate of degradation is not the same as regeneration. When you run out of telomere, you run out of telomere. Carnosine may delay it, but I've not been convinced that it can regenerate telomeric DNA.
c) Carnosine has been shown to have some beneficial cognitive properites in autistic children, is a well-documented free-radical scavenger, and can chelate some metals. Any others? Sources?

 

[NeuronalPerception]

a) I've never heard of TA-65, what is it?
b) Telomerase is only expressed (in mammals) in stem cells and certain cells that reproduce often (ie. immune system cells). Somatic cells have virtually no telomerase expression. Source. Do you have an abstract handy that shows that carnosine promotes telomerase expression? Otherwise I stand by my previous statement: reducing the rate of degradation is not the same as regeneration. When you run out of telomere, you run out of telomere. Carnosine may delay it, but I've not been convinced that it can regenerate telomeric DNA.
c) Carnosine has been shown to have some beneficial cognitive properites in autistic children, is a well-documented free-radical scavenger, and can chelate some metals. Any others? Sources?

1. Try google.
2. A matter of words.
3. You're unaware of it's effects on glycation? You should join A4M and LEF and get up to speed.

I don't need to argue with people who aren't even familar with these compounds or antiaging medicine. If anyone has any questions and real interest about anything I take feel free to ask and I'll gladly answer.

Dave any other questions you may pm me.

 

[Dave]

Nah, I'm not keen on your self-righteous attitude thanks. You've not answered my questions to any reasonable extent, and I have no reason to believe that you will via pm either. I'm not here to stroke anyone's ego.

 

[Mehm]

My question was, "is it working?" Also, do you have a specific reason to be so afraid of disease and dying? If you didn't take any of this, would you be healthy?....like so many people are in this world.

 

[negrogesic]

How do the massive doses of PEA fit into your regimen?

Can I ask, how long would you like to live, roughly?

Do you use hibiclens to wash your entire body?

I would rather die relatively quickly at a younger age then slowly degrade over time (I would imagine that even you would agree this does happen eventually). I liked Huxley's concept of dying at 65, but while still in good health.

May I ask, approximately how old are you?

 

[NeuronalPerception]

Nah, I'm not keen on your self-righteous attitude thanks. You've not answered my questions to any reasonable extent, and I have no reason to believe that you will via pm either. I'm not here to stroke anyone's ego.

Then simply stop posting here and wasting my time.

 

[NeuronalPerception]

My question was, "is it working?" Also, do you have a specific reason to be so afraid of disease and dying? If you didn't take any of this, would you be healthy?....like so many people are in this world.

Everyone ages. I would rather prolong my ideal health as long as possible. Nothing wrong with that is there?

 

[NeuronalPerception]

How do the massive doses of PEA fit into your regimen?

Can I ask, how long would you like to live, roughly?

Do you use hibiclens to wash your entire body?

I would rather die relatively quickly at a younger age then slowly degrade over time (I would imagine that even you would agree this does happen eventually). I liked Huxley's concept of dying at 65, but while still in good health.

May I ask, approximately how old are you?

They don't I have little need for a mood booster.

As long as I can offer this world something of value.

No but most.

If a proper antiaging protocol is in place the ideal state can last quite a long time.

 

[Mehm]

Everyone ages. I would rather prolong my ideal health as long as possible. Nothing wrong with that is there?

absolutely not

and you still haven't given your assessment as to if its working. Not that you can perform a double blind test or anything.

 

[Jabberwocky]

in my experience, mucking about with the acetylcholine axis (the major neurotransmitter most popular nootropics target) can do more damage than good.

Remember some of these nootropics (piracetam and potent choline donators in particular) can produce very strong effects that may knock your regular thought processes/cognitive stability completely out of whack.

Also there is very little long-term research on lots of these compounds. Drug interactions in particular (with psychedelics and empathogens) is really an unknown territory still.

Proceed with caution.

 

[fastandbulbous]

Considering the fact that without these chemicals I will die and suffer various diseases I would rather take a slight risk than not. I fully understand the reactions of everything I take based on all available research. Your general statement that doctors can't understand multiple reactions is flawed.

My wife works for poisons unit and is frequently appalled at the lack of pharmacological knowledge doctors & even a fair few consultants have, so it's far from any guarentee that doctors will have any better knowledge of pharmcology/pharmacokinetics than a well read layman (as I've discovered first hand of at least 2GPs at the practice I attend).

As a rule, doctors take a lot of their pharmacological knowledge from pharmaceurical reps who try to get them to prescribe their drugs - not exactly known for their impartial attitude, esp to drugs not produced by their firm

How do the massive doses of PEA fit into your regimen?

As it has vasopressor activity, I can't see how massive doses taken in order to try (pretty unsucessfully) can fit into any healthy regeime either. I'm far from mr healthy living, but I wouldn't even consider trying to eat several grams of PEA every day for an effect that very small doses of selegeline can achieve (which also protects your brain from oxidative stress from enviromental toxins etc. It also pritects against Parkinsons from crap in the enviroment thaty acts in the same way MPTP does, which is more tham PEA does)

in my experience, mucking about with the acetylcholine axis (the major neurotransmitter most popular nootropics target) can do more damage than good.

Yeah, excessive acetylcholine, as is seen in cases involving cholinerserase inhibitors, can cause the person to experience irrational amounts of extreme rage due to it's effects in the amygdala - several placid people have killed for utter petty reasons (one case I can think of was because a pest controller who'd been accidentally exposed was hasving a piss against a fence. A woman came out to have a word with him and he beat her to death. This was someone described as one of the most placid people you'd ever wish to meet) because of excessive acetylcholine levels due to cholinesterase inhibition.

That's beside all of the drooling cholinergic drugs like arecoline stimulate!

 

[fastandbulbous]

telemorase extends telemeres.

According to all the refs I can find it only slows down the deterioration of the DNA, not reverse it. Add that to this little gem from the BBC science program 'Horizon' (Life & Death in the 21st century) about telemorase and it could actually be more dangerous than harmful ie causing a reversal of the normal sequence of events for telomeres could push the cells into becoming cancerous

Noone knows how to insert genes into every cell of a living person. It is was possible, there would also be a risk of cancer, which is caused by cells that fail to die and continue to divide in an uncontrolled fashion.

The bit in italics is exactly what you're proposing - stopping & reversing cell death

Full article on BBC news here

 

[clamjuice]

When humans become more obsessed with extending their lifespan then living the life they have you gotta know we have an overdeveloped consciousness.

i bet you could surpass all those supplements and their effects if you just decided to live as happily as you could, im sure all the money youd save on those would go a long way!