[Mushrooms Subthread] First time Shrooming

[IamMe90]

Wellbutrin is an ssri and will really dull if not complty block the effects of the mushrooms. You would have have to probly be off of it for a couple of weeks for this interaction not to happen. Going off a medication you need is deffently not something you should do.

Even if someone has bi-polar that is under control; there is the risk of it bringing out symtoms.
I would advise against doing them.

Bupropion works on dopamine and noripinephrine, it is not an SSRI.

 

[pastelcircus]

Wellbutrin is an ssri and will really dull if not complty block the effects of the mushrooms. You would have have to probly be off of it for a couple of weeks for this interaction not to happen. Going off a medication you need is deffently not something you should do.

Even if someone has bi-polar that is under control; there is the risk of it bringing out symtoms.
I would advise against doing them.

yeah, this is actually very true
i hadn't thought my post out very much,
but psychedelics are probably for you not a good idea until AT LEAST you have yourself stabilized without the use of medications, which could take years if ever.
i've had some pretty traumatizing trips because of my mood swings,
and the 'advice' i had given you is kind of my way of making peace with it after the fact.
i wouldn't want you to have an unpleasant experience,
and i'm sure you wouldn't either.
be careful, use sound judgement, and don't rush into doing things like shrooms.

 

[pastelcircus]

also, don't go off your meds for shrooms
you are on them for a reason

 

[CheapHighMan]

also, don't go off your meds for shrooms
you are on them for a reason

I'll let him know.

 

[TheAppleCore]

you are on them for a reason

Maybe so. Chances are, it's his GP doing what he's paid to do -- shove drugs down his throat given the slightest excuse to do so.

 

[DwayneHoover]

Its not really known exactly how psychedelics do what they do. To state authoritatively that Wellbutrin will not affect shrooms because it is not an SSRI (actually it is a weak one I believe) is not legitimate based on such conjectures.

I was on Wellbutrin at one point and every psychedelic I tried was significantly blunted, including shrooms. I cant give a pharmacological explanation because, again, there is no definite absolute mechanism for shrooms effects that you can plug into a formula for Wellbutrin's mechanism and proclaim "no effect," that is just pure total hypothetical speculation, nothing more.

I did blunt shrooms at least for me.

 

[CheapHighMan]

Its not really known exactly how psychedelics do what they do. To state authoritatively that Wellbutrin will not affect shrooms because it is not an SSRI (actually it is a weak one I believe) is not legitimate based on such conjectures.

I was on Wellbutrin at one point and every psychedelic I tried was significantly blunted, including shrooms. I cant give a pharmacological explanation because, again, there is no definite absolute mechanism for shrooms effects that you can plug into a formula for Wellbutrin's mechanism and proclaim "no effect," that is just pure total hypothetical speculation, nothing more.

I did blunt shrooms at least for me.

Ok with that being said how much should my friend take. He wants effects that a regular person would get from half a gram. This is supposedly supposed to be a light dose and he is trying to be cautious.

 

[mad_demon_man_ant]

shrooms are chill, just dont fret about it and itll all work out. first time i did shrooms i did 5.5 grams, as long as you know how to handle yourself if you start to go over that edge of too mindfucked. as for the bipolar thing, my friend is bipolar and he seems to be fine when he trips just when he has a bad trip its REALLY bad but idk, could just be him.

 

[Potrick]

Its not really known exactly how psychedelics do what they do. To state authoritatively that Wellbutrin will not affect shrooms because it is not an SSRI (actually it is a weak one I believe) is not legitimate based on such conjectures.

I was on Wellbutrin at one point and every psychedelic I tried was significantly blunted, including shrooms. I cant give a pharmacological explanation because, again, there is no definite absolute mechanism for shrooms effects that you can plug into a formula for Wellbutrin's mechanism and proclaim "no effect," that is just pure total hypothetical speculation, nothing more.

I did blunt shrooms at least for me.

I was on 50mg fluvoxamine every day for 8 years. I had a mushroom trip of 3.5g April 18th of this year (first time at that dose) and afterwords I quit my medication forever and have been off since.

SSRI does not affect Mushrooms.

The trip was absolutely magical. Level 3 Experience with 3D closed eye visuals and warping in my periphery. I felt no more OCD tendencies (reason for medication) and I am forever changed.

 

[IamMe90]

Its not really known exactly how psychedelics do what they do. To state authoritatively that Wellbutrin will not affect shrooms because it is not an SSRI (actually it is a weak one I believe) is not legitimate based on such conjectures.

I was on Wellbutrin at one point and every psychedelic I tried was significantly blunted, including shrooms. I cant give a pharmacological explanation because, again, there is no definite absolute mechanism for shrooms effects that you can plug into a formula for Wellbutrin's mechanism and proclaim "no effect," that is just pure total hypothetical speculation, nothing more.

I did blunt shrooms at least for me.

Could be idiosyncratic, could be a host of things... the point is that welbutrin is not an SSRI (no, not a weak one... unless you can point me toward authoritative evidence saying otherwise, but I didn't find any from a cursory search. I could be wrong). It might blunt a trip a bit, maybe... I don't see this as anything particularly worrisome though.

Additionally, I think the way that 4-ho-dmt produces its psychoactive effects is fairly well understood, but whatevs.

 

[artic]

Maybe so. Chances are, it's his GP doing what he's paid to do -- shove drugs down his throat given the slightest excuse to do so.

I tend to share this sentiment, as it is something I have experienced myself when dealing with doctors. They are particularly likely to prescribe medications for chronic depression and bi-polar disorder, even to people complaining of only mild depression or mood swings. This doesn't mean, however, that some people don't need medication. Having done some personal research, I believe light cannabis use to be the safest medication for stabilizing and lightening mood, but it doesn't put money in pharma's pocket. No one can tell you whether or not you should be on mood altering medications. It is a personal decision that you should discuss with your doctor (not about taking shrooms though). Many people have success combating mood swings and depression with non-drug options, such as meditation (similar to what pastelcircus described), exercise, yoga, acupuncture, etc. Also, if you arm yourself with the tools you need to live your life, you won't be dependent on big pharma, which is a good thing. Yeah, don't stop taking medication if you feel you really need it, though.

Anyway, I wouldn't stop taking your medication just to take shrooms. Other BL-ers who seem to know more about your particular medications than I do seem to think it won't affect your trip much, if at all. I would suggest starting with a 1-2g dose, just to assess the potency of the mushrooms and your sensitivity to them. I suspect that your medication will make the trip a bit more mild, so at some point in the future if you stop taking your Wellbutrin, start at a lighter dose than you usually take. Actually, I think that starting with a light dose when you get a new batch is always a good idea, since potency of mushrooms tends to vary quite a bit.

 

[CheapHighMan]

K thanks for the help I'll let you guys know how it gos

 

[perKeceT]

apart from the wellbutrin issue. my skimming didnt notice anyone mentioning the abilify, which is an anti-psychotic. i dont think youll trip man.
edit: also ill back up the others with DONT stop taking your medication please. and also, a half gram of plain ole cubensis wouldnt even give effects would it? i need about a gram before i feel anything other than i little tingle in my brain. if youre set on trying this, id say 1.5 grams would be a good starter dose.

 

[CheapHighMan]

My friend is wondering if there's anyway he can trip.

What I'm wondering is why can't he trip on abilify.

 

[greenmeanies]

aripiprazole is a mixed dopamine antagonist and partial serotonin agonist/antagonist. this could mean one of three things:

1. aripiprazole will be taking up space at the receptors that are necessary for tripping (5HT2A), making any psilocybin just sit around not doing anything. Thus "antipsychotics will block a trip" unless your friend takes a stupidly high dose.

2. the dose of aripiprazole may not be high enough to "fill up" the first receptors that it hits (the dopamine ones mainly) meaning 5HT2A will be basically unaffected. psilocybin tripping will be totally possible, and at a dose that would be considered normal for most people.

3. the antagonist effects of the aripiprazole have modified the brain's normal levels of neurotransmitters and receptors, possibly leading to increased sensitivity to certain effects of psychedelic drugs. meaning your friend might trip his balls off with only half a gram of mushroom. or get tons of emotional effects with zero visual. or the other way around.

I cannot tell you which of these three cases might happen. but drug combinations are inherently risky especially when one of them is specifically designed to "calm down a schizophrenic patient" as that's the only legal reason for drug companies to patent new chemicals. Be supportive of your friend's emotions, spend a good long time working with him BEFORE you trip so you will be better able to assist him in case he needs a shoulder to punch or cry on.

 

[perKeceT]

antipsychotics are used to terminate psychedelic trips. im no expert in how pharmaceuticals work, but i know that seroquel and medications like it will stop a trip dead in its tracks. i dont know if theres a difference unique to abilify, im just basing it on it just being an antipsych. i dont think it would cause you any harm to try though, you would just not get any effects whatsoever.

 

[greenmeanies]

quetiapine is indeed a very different drug, even though they are both "antipsychotics"

as i said before, aripiprazole is most selective towards antidopamine, so a small dose of aripiprazole might not even touch the serotonin system at all. quetiapine on the other hand is highly selective towards antihistamine and antiserotonin action before it would begin to show antidopamine action.

 

[perKeceT]

^thank you for clearing that up, your much more informed post above mine wasnt there when i began typing my response lol.

 

[DwayneHoover]

let us know what happens if anything. I agree .5g is probably below the level of detectability. 1.5 is enough to feel in normal situations, but that would still typically be a very mild experience with mostly just body buzz and perhaps a little color brightening and trails... but on those multiple meds, there's really no way to predict what will happen as others already pointed out. But yea 1.5g seems like a good compromise that should be pretty safe, but these guesses are just that guesses... anything could happen (or nothing) to be honest.

Again, good luck! Report back!

 

[atara]

Maybe so. Chances are, it's his GP doing what he's paid to do -- shove drugs down his throat given the slightest excuse to do so.

It is probably worse to take shrooms during antipsychotic withdrawal than to simply take them without stopping whatever you're on. Aripiprazole et al can have some "discontinuation syndrome" that is not very pleasant.