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Most physically-changing drug.

I would say heroin is the least taxing on the body out of all the drugs.

Did you ever goto an AA meeting and look at the alcoholics? They all have bags under their eyes and look horrible.

I really find that most heroin addicts look younger than they are. Obviously when someone is on it they look like shit, but usually after a month you can never tell.

So i would have to say the drugs that do the worst damage would be:

Meth
Crack
Alcohol

O yea look at robert downy junior he was a doper and he looks great now that hes clean, and hes been in the game for a while.
 
Meth, for fucking sure. My friend, who used to be very overweight, lost about a hundred pounds. Also, when I went to rehab, I saw a LOT of tweakers (this is Oklahoma after all), and they were missing teeth and their faces were sunken in and they looked absolutely terrible. Not to mention it does irreparable damage to your CNS.
 
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