Opioids Morphine/opioids with trimipramine

[andrey]

Hello guys,

As some of you may know, first generation are supposed to be great in combination with opioids. Especially, promethazine, phenyltoloxamine, phenindamine or tripelennamine seem to enhance the euphoria from opioids.
Unfortunately, most of them are hard to get nowadays; I believe for this exact reason.

I read in a german speaking drug forum(eve rave) that there was one guy who was searching for the perfect antihistamine combination for opioids. He liked promethazine obviously, but he also mentioned that trimipramine is a fine choice.


Trimipramine itself is an antidepressant with almost nil monoaminergic reuptake inhibition, yet its allegedly still a good AD. It primarily antagonizes histaminergic(h1, h2), serotoninergic(5ht2a) and adrenergic(a1). It also moderately blocks cholinergic receptors and even dopaminergic receptors weakly. In fact, it has a similar binding profile to clozapine.
It also works great for sleeping, „brightens“ REM sleep and overall seems to be very effective for that indication.

Im thankful for any experiences or information.

 

[paranoid android]

Ive taken morphine with trimipramine and not noticed any potentiation really

 

[andrey]

Ive taken morphine with trimipramine and not noticed any potentiation really

Well for me, it dampens opioid withdrawal symptoms, especially at higher doses. But 25mg is already enough to deal with softer symptoms. Same goes for example for doxepine.
I read somewhere that TCA influence opioid receptors indirectly.

Arent you the guy who is also into morphine? Have you ever tried some of the 1. generation antihistamines, or is there any other drug combi you can recommend(except for like pregabaline, low dose alc or benzos…)?
Taking magnesium and potassium a day before the morphine helps with euphoria actually.

 

[headshrinker89]

Kinda off topic but I never understood how promethazine or chlorphenamine potentiate codeine. Aren't they CYP2D6 inhibitors? Or are they weak inhibitors?

 

[drewbocop]

Trimipramine itself is an antidepressant with almost nil monoaminergic reuptake inhibition, yet its allegedly still a good AD. It primarily antagonizes histaminergic(h1, h2), serotoninergic(5ht2a) and adrenergic(a1). It also moderately blocks cholinergic receptors and even dopaminergic receptors weakly. In fact, it has a similar binding profile to clozapine.
It also works great for sleeping, „brightens“ REM sleep and overall seems to be very effective for that indication.

Well, wnen you put it like THAT... doesn't sound too bad lol