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Moclobemide and Methadone

jasoncrest

Bluelighter
Joined
Sep 15, 2003
Messages
3,952
Location
France
I don't find any precise on the interactions between Moclobemide and Opiates (Methadone).
Moclobemide, for those who don't know, is a short-acting, reversible inhibitor of MAO-A. It doesn't interact with drugs like other MAOI do. There are almost no contraindications with food and drugs.

Some webpages say that Moclobemide should not be taken with Opiates, because it can cause dangerous, as the combination is dangerous.

Many other sites, however, say that Moclobemide potentiates Methadone; but they can be taken together: you just need to adjust your Methadone dosage (take less).

So if I take less Methadone than usual, would it be safe to take Moclobemide?
(I would like to take Moclobemide daily, as an antidepressant)

If anyone finds a webpage on the subject (Moclobemide+Methadone), please post the link, I need to read about the subject).
 
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No one knwos if it's dangerous to take Moclobemide (an MAOI) with Opaites (especially Methadone)??
Does it potentiate the effects?
 
It's probably not the best idea, like SSRIs... it shouldn't potentiate it, but you might be risking serotonin syndrome... I can't find any specific evidence... don't mix drugs unless you have to; it's always that simple.
 
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