Greetings!
I've recently begun a treatment with milnacipran (Ixel), an SNRI that affects norepinephrine and serotonin nearly equally (a 3:1 norepinephrine to serotonin balance as opposed to Effexor, with a 1:30 norepinephrine to serotonin ratio). I am also in the process of planning a 10-day vacation in Holland and would be very sad if I couldn't test out the most recent Cannabis Cup award winners.
The memories are very hazy, but I believe that I have smoked pot on Effexor in the past, with no horrible results. Google and Erowid however tell me that it would be stupid to even think about it - loads and loads of reports of emergency room cases. 8)
Ixel is obviously a very different drug.
Milnacipran exerts no significant actions on postynaptic H1, Alpha1, D1, D2 and muscarinic receptors as well as on benzodiazepin/opiate binding sites.
Interactions:
* MAOIs, Lithium - serotoninergic syndrome, potentially lethal
* 5-HT1AD-Agonists - coronary vasoconstriction with risk of angina pectoris and myocardial infarction
* Epinephrine, Norepinephrine (also in local anesthesia) - hypertensive crisis and possible arrhythmias
* Clonidine - antihypertensive action of Clonidine may be antagonized
* Digitalis - hemodynemic actions increased
* Alcohol - no interactions known
Half life 8 hours
Can anyone tell me from personal experience or based on this information whether i should avoid smoking pot while on this drug?
If so, then what kind of "cleansing" period should i be looking at if i wanted to "purify" my system for the vacation?
The information on this medication seems extremely limited - thanks in advance for any comments or suggestions.
I will be posting my user experience once I level out on the AD.
I've recently begun a treatment with milnacipran (Ixel), an SNRI that affects norepinephrine and serotonin nearly equally (a 3:1 norepinephrine to serotonin balance as opposed to Effexor, with a 1:30 norepinephrine to serotonin ratio). I am also in the process of planning a 10-day vacation in Holland and would be very sad if I couldn't test out the most recent Cannabis Cup award winners.
The memories are very hazy, but I believe that I have smoked pot on Effexor in the past, with no horrible results. Google and Erowid however tell me that it would be stupid to even think about it - loads and loads of reports of emergency room cases. 8)
Ixel is obviously a very different drug.
Milnacipran exerts no significant actions on postynaptic H1, Alpha1, D1, D2 and muscarinic receptors as well as on benzodiazepin/opiate binding sites.
Interactions:
* MAOIs, Lithium - serotoninergic syndrome, potentially lethal
* 5-HT1AD-Agonists - coronary vasoconstriction with risk of angina pectoris and myocardial infarction
* Epinephrine, Norepinephrine (also in local anesthesia) - hypertensive crisis and possible arrhythmias
* Clonidine - antihypertensive action of Clonidine may be antagonized
* Digitalis - hemodynemic actions increased
* Alcohol - no interactions known
Half life 8 hours
Can anyone tell me from personal experience or based on this information whether i should avoid smoking pot while on this drug?
If so, then what kind of "cleansing" period should i be looking at if i wanted to "purify" my system for the vacation?

The information on this medication seems extremely limited - thanks in advance for any comments or suggestions.
I will be posting my user experience once I level out on the AD.