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milnacipran (ixel) + marijuana ???

G

glitch23

Greenlighter
Joined
Apr 12, 2007
Messages
14
Greetings!

I've recently begun a treatment with milnacipran (Ixel), an SNRI that affects norepinephrine and serotonin nearly equally (a 3:1 norepinephrine to serotonin balance as opposed to Effexor, with a 1:30 norepinephrine to serotonin ratio). I am also in the process of planning a 10-day vacation in Holland and would be very sad if I couldn't test out the most recent Cannabis Cup award winners.

The memories are very hazy, but I believe that I have smoked pot on Effexor in the past, with no horrible results. Google and Erowid however tell me that it would be stupid to even think about it - loads and loads of reports of emergency room cases. 8)

Ixel is obviously a very different drug.

Milnacipran exerts no significant actions on postynaptic H1, Alpha1, D1, D2 and muscarinic receptors as well as on benzodiazepin/opiate binding sites.

Interactions:

* MAOIs, Lithium - serotoninergic syndrome, potentially lethal
* 5-HT1AD-Agonists - coronary vasoconstriction with risk of angina pectoris and myocardial infarction
* Epinephrine, Norepinephrine (also in local anesthesia) - hypertensive crisis and possible arrhythmias
* Clonidine - antihypertensive action of Clonidine may be antagonized
* Digitalis - hemodynemic actions increased
* Alcohol - no interactions known

Half life 8 hours

Can anyone tell me from personal experience or based on this information whether i should avoid smoking pot while on this drug?
If so, then what kind of "cleansing" period should i be looking at if i wanted to "purify" my system for the vacation?:)

The information on this medication seems extremely limited - thanks in advance for any comments or suggestions.
I will be posting my user experience once I level out on the AD.
 
You can safely combine Milnacipran (and every other SNRIs or other antidepresants) with Marijuana.

I think you can safely combine marijuana with everything...
 
im not entirely sure but i will attempt to help if i can....
is milnacipran (Ixel) an anti depressant??

if so i will check the active ingredients in all the anti depressants that i have tried in the past (ive been on about 7 or 8 different 1s) and have smoked cannabis while using most.....with the worst side effects being nausia or heavy sleep...!
this isnt to say that you will feel/get the same effects,i can but check ...
 
rulerofthecosmos said:
im not entirely sure but i will attempt to help if i can....
is milnacipran (Ixel) an anti depressant??

if so i will check the active ingredients in all the anti depressants that i have tried in the past (ive been on about 7 or 8 different 1s) and have smoked cannabis while using most.....with the worst side effects being nausia or heavy sleep...!
this isnt to say that you will feel/get the same effects,i can but check ...
Click to expand...

Yes, milnacipran is an andidepressant, approved and sold in Austria since September 1998 under the brand name Ixel.
Which antidepressants have you smoked on? The combining effects would probably vary depending on which one you're taking..
 
glitch23 said:
oo, i don't know about that.. check this out:
http://www.erowid.org/experiences/exp.php?ID=37418
or.. http://mb.rxlist.com/rxboard/effexor.pl?read=2867
even the mental health sanctuary!:) http://www.mhsanctuary.com/therapist/1159.htm
8)
Click to expand...

Oh shit, all i said above is wrong.

Don't combine Ixel with cannabis, it can be hazardous...

(read the links shown by glitch23, knowing that Venlafaxine is Effexor, and Effexor is an antidepressant with exactly the same action than Ixel, they are both SNRI)
 
glitch23 said:
Yes, milnacipran is an andidepressant, approved and sold in Austria since September 1998 under the brand name Ixel.
Which antidepressants have you smoked on? The combining effects would probably vary depending on which one you're taking..
Click to expand...

Prozac, norpress(nortryptyline),Aropax...are 3 i can think of off the top of my head......i can find the rest and post them on here when i do....

the advice by ALL physicians is to NOT mix antidepressants with alcohol or any other drugs! Im not here to encourage other wise but you sound like a responsible user who has/is done and doing their homework glitch23 so good luck and i hope you find your answer...!:\
 
and yes the effects do slightly vary depending on what anti depressant and what strain/how much cannabis is consumed but as i already stated I have found no real bad side effects when ive consumed cannabis.....but the 1 time i recall drinking a fair amount of alcohol on prozac i became very ill and didnt have a good time at all...
 
jasoncrest said:
Oh shit, all i said above is wrong.

Don't combine Ixel with cannabis, it can be hazardous...

(read the links shown by glitch23, knowing that Venlafaxine is Effexor, and Effexor is an antidepressant with exactly the same action than Ixel, they are both SNRI)
Click to expand...


actually, their mechanism is quite different. Both drugs are qualified as SNRI-s, but Effexor is a billion times more selective for serotonin - hence, the serotonin syndrome / toxicity horror stories (?).

The reason I believe combining pot and ixel might be alright, is that mirtazapine is neither an SSRI nor significantly serotonergic. Marijuana does not directly produce serotonin.

Duloxetine is an SNRI as well, and, according to one of the users on this forum, it caused insomnia when combined with cannabis.

I think i might actually get away with it. i'll report back.
 
oh and btw, consuming alcohol on milnacipran is pretty much fine.
obviously it's a little bit counteractive to consume depressants on an antidepressant treatment, but a few beers won't kill you or make you vomit.
i've noticed a lowered tolerance effect though.
 
This thread seems to have stopped getting responses in BDD, so I have moved it to CD. When the thread stops getting responses in CD (i.e. no responses for 2 or more days), can the CD mods send it on over to ADD? Thanks.
 
I have been taking effexor for a good year now, and I smoke weed all the time. I don't smoke every day though. I only smoke 2-3 times a week at most. I have never had that effect, but I do seem to get a lot more fucked up than those who smoke with me. I don't take the effexor right before I smoke though, and I usualy forget to take my pills when I'm high. Is this dangorous, and if it is still dangerous even when I take them seperately? I take my pills before bed usualy midnight, but I smoke around 6 give or take.I don't want to have to quit:(
 
I've recently had Effexor XR 75mg and smoked some weed on it. The effexor had me COMPLETELY TWEAKED OUT with or without the weed, my systolic was well above normal and heartrate was pretty high too. I would be extremely cautious about mixing weed with anything that causes an increase in blood pressure and heart rate. At the very least have some strong, quick acting sedatives on hand.
 
Those seizures described on erowid from the combination of venlafaxine and cannabis sound quite nasty actually, i'd never heard about that contraindication (or indeed any drug being specifically contraindicated with cannabis)...and the multiple case reports are almost identical which suggests a direct interaction.

I'm curious about the mechanism by which this is happening, and how widely known the danger of this combination is among doctors, especially now that cannabis is being more widely used in medicine...they suggest that its a serotonergic effect but that would imply that cannabis combined with any SSRI could cause convulsions and i've never heard of it being known as a problem.
 
I really don't see any problem with smoking weed whilst on SSRIs or SNRIs.
Their methods of action are vastly different and don't offer much in the way of possible interactions.
In all honesty weed is probably the safest mixer recreational drug there is (but that doesn't mean it's /always/ safe! As F&B points out it can potentiate barbs...) .
 
I was unaware that cannabis somehow acted as an agonist on the 5-HT system. Does anyone have a reference for this, preferrably with some quantitative information?
 
done and tested:)

So I did my research and decided to give the abovementioned combo a shot.
Took 50mg milnacipran at around 17:00 and toked at 22:00 with 0.25 mg of xanax in the bloodstream.
ended up having a pretty good time. the high hit a little faster and more intensely than expected, but all in all a familiar, relaxed experience.

What puzzles me about the Erowid case report is that the guy who seized up had been smoking pot for at least a week prior to the incident. I find it difficult to believe that cannabis would have this kind cumulative effect. Perhaps this whole thing was his reaction to Effexor, which can be no fun in and of itself...
 
here's the math that i did..

Many drug interactions are a result of inhibition or induction of CYP enzymes.

The primary means of metabolism for both D8-THC and D9-THC and their metabolites is via CYP3A4, with a more modest role by CYP2C9.71–73

The metabolism of milnacipran does not require cytochrome P450 (CYP)-enzyme-mediated biotransformation.

My guess is that since milnacipran and THC are metabolized by rather different enzymes, drug-drug interaction risk would be low.
(Does anybody even know what new drugs like milnacipran are metabolized by?)

Venlaflaxine, however, is extensively metabolized in the liver via the CYP2D6 isoenzyme... not the same enzyme as THC but close..
Hence the potential interaction?




http://www.ncbi.nlm.nih.gov/entrez/...ist_uids=17303175&cmd=Retrieve&indexed=google
 
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