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  • Trip Reports Moderator: Cheshire_Kat

(Methoxetamine/25 mgs) First time: Heaven on Earth

I haven't posted in a while here at BL, but a good friend of mine pointed this report out.

And I'm very intrigued to read about this compound and it's wonderful effects.

But I was wondering, if the methoxy group were to be replaced with an hydroxy wouldn't it be a better agonist at the μ-opioid receptor? Or will it lose all it's NMDA activity? Or were you afraid that the opioid activity would overshadow all the other effects?

And just for the record, I suppose that you tried the racemic mixture?
 
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Yes it was raecamic. I Supppose the ultimate test would have beeen with the S-isomer, but that's beyond our mere capabilities! =D 3-HydorxyPCP was a nightmare, so 3-methoxy was the closest I was going closest I was going to get to opiate activity (possibly 3-hydroxyarylcyclohexylamne didn't crosss the blood brain barrierr as well)

If thr target had been a crug of abuse/antidepressant then the methoxy would have won out, but for generaklanaeesthesia. a 2-chloro group seems to be the best (possibly thry could have gone to the broimine atom, but who are we to argue?)
 
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^Man your avatar trips me out sometimes, I see it move in my peripheral vision but then it takes so long to move again sometimes I think it actually doesn't move and I'm just seeing it. lolz
 
ex-amine said:
somewhere between ketamine and tramadol (to keep it simplish).
but seemingly with the properties of both.
Opiate and disosiative in one.
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Like methadone?

Interesting TR, F&B! Well written.

tBirdee said:
^Man your avatar trips me out sometimes, I see it move in my peripheral vision but then it takes so long to move again sometimes I think it actually doesn't move and I'm just seeing it. lolz
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LOL, yeah his avatar is pretty sweet.
 
^ Was waiting for you to comment. You'd love the stuff (not quite sure about the plain unsubstituted ring one, it was a little too like tiletamine - all bleak and charmless). At least it'll stop me bleating on about won't somebody make & try it! =D

The first one is 3-MeOPCE with a keto group on he cyclohexyl ring, the second one is the keto version of plain PCE (funnily enough, PCE wasn't cold & charmless, I sort of liked it except for the fucked memory). Wonder what the keto version of PCP would be like (other than being a pain to make) - tertiary heterocyclic amine functions would be a bastard to add on

Of the other 3-methoxyPCP series, I think the 3-methoxy-N-isopropyl analogue of ket would be interesting (I think this was the erotogenic one - 3-MeOPCIP)
 
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^ :)

I personally did not find value whatsoever in isopropyl compound (of PCP) - in fact I found it quite dysphoric and muted. At least 3-MeO-PCP was insightful somehow.

This, though, is interesting. I still maintain that the basic Ketamine backbone probably has magic in and of itself (necessiating a chlorophenyl and a keto group - both of those) which would produce interesting substituted compounds on the amine.

EDIT: Wait... um, isn't this compound just 3-MeO-PCE? Or the Ketone? Baaah, still far from a ket analogue, but still interesting nontheless ;)

But then again you have all the SARS data, which btw I am still waiting for you to email me ;).

Would you say that this compound (how can we shorten the name ?) produced significant dissociation from one's senses? The "zing" that reminds one of N2O, and which I found only Ketamine and plain PCP produce?

EDIT: Oh nevermind that last question, I think this post of yours answers it already:

fastandbulbous said:
Yes it was raecamic. I Supppose the ultimate test would have beeen with the S-isomer, but that's beyond our mere capabilities! =D 3-HydorxyPCP was a nightmare, so 3-methoxy was the closest I was going closest I was going to get to opiate activity (possibly 3-hydroxyarylcyclohexylamne didn't crosss the blood brain barrierr as well)

If thr target had been a crug of abuse/antidepressant then the methoxy would have won out, but for generaklanaeesthesia. a 2-chloro group seems to be the best (possibly thry could have gone to the broimine atom, but who are we to argue?)
Click to expand...
 
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Thanks for the report. Of the dissociatives I've tried, this sounds closest to 3-MeO-PCP, but one or a few steps more opiate like, less dissociative like, and more euphoric. Is that an accurate assessment? Besides euphoria, can you expound on the emotional and cognitive effects a little more? For me, the greatest values of 3-MeO-PCP are that it enhances emotions -- it made me start crying from extreme feelings of reverence for Mark Twain and love for my long departed grandfather of all things, heh -- and has more 5-HT psychedelic-like effects relative to other dissociatives I've used.
 
I'm glad to see that there is finally someone who has the resources, desire, and initiative to explore all of the ketamine analogs. I am eagerly awaiting your publication of "Arylcyclohexylamines I have Known and Loved" lol.

A little off topic, but has anybody explored the effects of ketamine analogs with other halides substituted on carbon 2 of the benzene ring?
(S)-2-(2-bromophenyl)-2-(methylamino)-cyclohexan-1-one sounds interesting...
 
Who knows - depends upon if any of the vendor types think it sounds a worthwhile material.

Aooarently you can hole wiht the stuff (what my friend referred to as a 'whole' as it was so life affirming) so yes it does have a lot of the emotional enhancement that say 3-MeOPCP has, but it also has a certain je ne sais quoi that makes it something rather special in my opinion. The opiate aspects do not detract from the dissociative side, but instead are an added bonus. The only downside I can see with this is that if ketamine is highly psychologically addictive, then this stuff has 10x ketamine's potential for grabbing your psyche by the short & curlies!
 
Metcalf said:
Any ideas on how the 4-oxo version of this might size up? That would be 4-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone.

In this thread the 4-oxo and 2-oxo-PCP analogs were tried as well: http://www.bluelight.ru/vb/showthread.php?t=504286
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Probably a lot more opioidin activity with a sizeable reduction in dissociative activy - well that's what happens to arylcyclohexylamines with a 4-oxo group from thost that have been synthed & tried


Would I be correct in guessing this will be schedule purely due to the Analogue Act?
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For UK (seeing you say you're from the UK), no; we don't have an analogue act, just some rather wide ranging bits of legislation covering derivatives of various compounds, of which arylcyclohexylamines isn't one.

Saying that though, I don't think the powers that be would be happy if they found you with say 10kg of the stuff! =D
 
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