I was on 375 mg of methadone (liquid) could not feel any other opiates, even if i took 4x brand 80mg oxys. Before i was on the liquid i was on 240 mg of the methadone wafers, even when i was on them, i could not get off on high amounts of Heroin. that was years ago. I tried to stay sober and clean, but have such severe pain from a woman on a cell phone deciding not to use her brake pedal when i was at a complete stop and she was going 50+ mph, i have 6 cracked disks, all which are herniated ontop of it. i am now on 40 methadone (10mg)4x's a day, pills along with 6x norco's (10/325) and it works alright for my back pain, methadone at higher doses does not block the opiate but it makes your tolerance so high that it is damn near physically impossible to catch a buzz/high from anything including heroin. I would try and do H and wouldnt feel a thing. Whatsoever. I ended up kicking the methadone for a while, went back to H, and after a week without the methadone i could feel all the opiates again,(dilaudid, norcos, demmys, MS Contin, Oxys) all that stuff, suboxone and the buro are the only ones that have the Naloxone in them to block opiates. there are other drugs out there that are for opioid blockers too such as naltrexone. I am trying to get put on my regular 40 mg of methadone+ roxys for breaththrough or dilaudid, i think they are the best combo. But no methadone does not block the opioid it just gives u a tolerance from hell in which you could do enough opiates to kill a horse and you will still be standing. This is from personal experience, i am not a doctor, just explaining what my, and many friends of mine went through. Also i notice if you stay on a low dose of methadone (40mg a day for isntance) you can feel other opiates such as norcos, dilaudids, roxys, all of that, and actually get pretty much the full effect.
