I found this out the hard way, in solitary confinement, "sleeping" on a frigid concrete floor, after being picked up on charges after a very short prolific bender, in which I ingested at least half a gram intravenously (plus 4 tabs of LSD preceding it throughout the day) in a short period of time.
It took me 48-72 hours to regain some semblance of sanity, as of course, the good jail doctor simply thought it prudent to ensure I raw dog one of the worst, insanely long & delusional comedowns of my life, despite my insistence I had prescriptions outside for anti-psychotics that would help immensely.
Despite the brutality I felt in my week in solitary, it was basically a spiritual experience for me and a major turning point in my life.