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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Mephedrone Megathread: Five heart attacks later...

Waterfall said:
Just found this news article: http://www.lurganmail.co.uk/news/Drug-problem.5814209.jp

I'd just like to point out this quote:

"Mephadrone is known in street slang as Plant Food, Mugabe, Meow, Meph, Magic or Bath Salts."

...Erm, Mugabe?
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Oh.My.God 8o8o

I'll let the man himself comment on this one, but on his behalf, HAHAHAHAHA!!!

...AHAHAHAHAHA....


Edited to try to add something vaguely content-like....

Rickyo -- I agree with the others -- drink turns willpower to mush and also adds 100x to all feelings of guilt. Try not to beat yourself up too much -- it's pretty pointless.
 
Cheers guys. I'll try and go a bit easier on myself. I'm hoping this one off incident won't cause me any problems.

This quote from this post scares me a lot though:

This is a post from the other mephedrone thread, but it should probably be here too:

Quote:
You don't even need to justify it by saying that it's a metabolite -- it's well know that putting a hydrophobic atom into the 4-position increases an amphetamine's affinity for SERT and thus serotonin release, which is well known to be a precursor for amphetaminergic neurotoxicity and cardiotoxicity.

EC50 DA/NE/5HT nM

d-Amphetamine 8.0±0.43, 7.2 ±0.44, 1756±94
meta-Methylamphetamine 33.3±1.3, 18.3±1.4, 218±22
para-Methylamphetamine 44.1±2.6, 22.2±1.3, 53.4±4.1

Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, Woolverton WL (2005). "Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs.". J Pharmacol Exp Ther 313 (2): 848-54.

The affinity of methcathinone and methamphetamine for DA/NA/5HT release is as follows:

EC50 DA/NE/5HT nM

(+)-Methamphetamine 12.3 ± 0.7, 24.5 ± 2.1, 736 ± 45
(–)-Methcathinone 13.1 ± 0.6, 14.8 ± 0.4, 1772 ± 160

Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, Glennon RA. (2003) In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J Pharmacol Exp Ther. 307(1), 138-145.

We can only make an educated guess that 4-Methylmethcathinone is somewhere between methcathinone and 4-Methylamphetamine in terms of 5HT release, and given that it's very possible we're dealing with a strongly neurotoxic and cardiotoxic agent. I mean, methamphetamine is incredibly neurotoxic yet is 60x preferential for DA over 5HT compared to 220x preferential for amphetamine, while 4-Methylamphetamine's ratio is 1.2x!
Think of the potential: An agent that could induce the apoptosis of dopaminergic and serotonergic neurons at many fold the pace of regular old methamphetamine!
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http://www.bluelight.ru/vb/showthread.php?p=7615342#post7615342
 
MeDieViL said:
Alcohol sucks, last time i was drunk i would have taken meph if i had some the place is was sleeping (at my other home i still had a gram) while i am on a mdma/meph break this would have totally destroyed my effort of months not taking those drugs.

Better have GHB instead alcohol, it doesnt make you crave as much.
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I'm going to have to not drink in any situations where there is meph, as I don't trust myself any more. It's crazy how once you are high your way's of thinking change completely. I decided I was doing the right thing last night, and that I had been silly to ever worry about doing meph. I was planning on ordering loads more today and really getting into it. Doing a gram was no problem in the slighest, although to be honest I could have stopped at 600mg fairly easily but I was so weak and kept going for the sake of it. I stopped really enjoying it then as I had to be so quiet not to wake my parents I was paranoid they would catch me.

My mates are all informed that this drug might be bad news, so hopefully they wont be buying any more and as time goes on I wont ever ben in situations where it is around.
 
I wouldn't worry much about the damage of the MDMA anyway. Myself and several mates have taken stupid amounts of it in a weekend with no bad side effects other than the obvious comedown. Even after the equivlant of 2gr in one night I've never really felt that bad from it.

As others have said don't beat yourself up. Usually as soon as I have a few drinks I want some drugs and to get smashed :D Most people I know are the same. A g of meph in a night isn't that bad either. I concider 500mg-1g to be quite moderate and am usually fairly happy if I stay under a g. Have been stupid in the past with doing too much, as I'm sure most people have at one point. :)
 
captain codshit said:
I wouldn't worry much about the damage of the MDMA anyway. Myself and several mates have taken stupid amounts of it in a weekend with no bad side effects other than the obvious comedown. Even after the equivlant of 2gr in one night I've never really felt that bad from it.

As others have said don't beat yourself up. Usually as soon as I have a few drinks I want some drugs and to get smashed :D Most people I know are the same. A g of meph in a night isn't that bad either. I concider 500mg-1g to be quite moderate and am usually fairly happy if I stay under a g. Have been stupid in the past with doing too much, as I'm sure most people have at one point. :)
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Cheers mate. That post particularly helps actually since one of my biggest worries is from when I did 2.5g over 10 hours. I am starting to believe now that maybe I haven't actually done as much damage as I feared.

I am worried about the meph though as some things seem to hint that it does loads of damage. That quote I posted above seems to think its about 40 times as damaging as methamphetamine!
 
angelsmoke said:
Oh.My.God 8o8o

HAHAHAHAHA!!!

...AHAHAHAHAHA....
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QFT =D

And if I may add: Bwahahahahahahaahahahahahahh!!!!! =D=D=D

captain codshit said:
I wouldn't worry much about the damage of the MDMA anyway. Myself and several mates have taken stupid amounts of it in a weekend with no bad side effects other than the obvious comedown. Even after the equivlant of 2gr in one night I've never really felt that bad from it.
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Not feeling shitty is no indication of how much damage has been done so not a very reliable way of guaging toxicity :)

Having said that, I seriously doubt you have anything to worry yourself about, Rickyo. Meph may not be the healthiest thing to be doing but in the grand scheme it's unlikely to have done any real damage from one-off use. Suspect you'd have to be unbelievably unlucky or work a lot harder at abusing it to have any cause for concern. No need for self-flagellation :)<3
 
Shambles said:
Having said that, I seriously doubt you have anything to worry yourself about, Rickyo. Meph may not be the healthiest thing to be doing but in the grand scheme it's unlikely to have done any real damage from one-off use. Suspect you'd have to be unbelievably unlucky or work a lot harder at abusing it to have any cause for concern. No need for self-flagellation :)<3
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Thanks mate, thats cheered me up.

I feel like a dick after taking your advice just a day or so ago that I should stay clear from the stuff and being like "yeah yeah, your defo right, I'm gonna be sensible and not touch it" (and felt quite proud in myself for making the right choice for the first time), and then the next thing I'm posting how I nailed a gram!!!

8(:|8(
 
Honestly rick, the 1 gram is a piss in the ocean compared to the amounts many of us have taken, don't sweat it.
 
Yerg said:
Honestly rick, the 1 gram is a piss in the ocean compared to the amounts many of us have taken, don't sweat it.
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yeah man, what he said. If you wanna really feel bad about yourself, do what I did the first time I got a quantity of it and stay up for 58 hours straight with a resting pulse around 170, blowing through a good 3.5 grams, getting so reckless chasing the high that you find yourself at one point attempting a 300mg rectal dose 8o


Just be happy you only had a gram! Everyone's gotta learn for themselves the first time how feindish this stuff is, it doesn't matter how much you read about it, that shit get's ya the first time.
 
Dragynfyr said:
yeah man, what he said. If you wanna really feel bad about yourself, do what I did the first time I got a quantity of it and stay up for 58 hours straight with a resting pulse around 170, blowing through a good 3.5 grams, getting so reckless chasing the high that you find yourself at one point attempting a 300mg rectal dose 8o


Just be happy you only had a gram! Everyone's gotta learn for themselves the first time how feindish this stuff is, it doesn't matter how much you read about it, that shit get's ya the first time.
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Very ture.

I actually found it fiendish in a weird sort of way. I felt in control and like I could stop at anytime. I actually sectioned out 400mg and was just going to do that. I even hid the other 600mg in my parents bedroom. However, I finished the 400mg before my parents went to bed, and I recovered the 600mg and hid it in my room thinking I was done and wouldn't do any of it.

Then, of course, I went to just do "a little bit more", genuinely thinking I would never finish the lot. But I kept doing little bits more until it was nearly all gone.

I wasted about 300mg actually but doing it in 3 doses spread far apart at the end. I think my tolerance was up by then, and 100mg doses weren't enough to really do much.
 
Rickyo said:
I wasted about 300mg actually but doing it in 3 doses spread far apart at the end. I think my tolerance was up by then, and 100mg doses weren't enough to really do much.
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lol and ya think you would learn your lesson after the first 100mg line didn't do the trick, but nooo, it stays in the back of your head and before ya know it you've been up 12 more hours than you planned.
 
Dragynfyr said:
lol and ya think you would learn your lesson after the first 100mg line didn't do the trick, but nooo, it stays in the back of your head and before ya know it you've been up 12 more hours than you planned.
Click to expand...

"THIS line will work..."

30 mins later

"THIS one will DEFINITELY work..."


and repeat... :o
 
Gonna break my sobriety with some mugabe in the next week or so, getting a free 500mg sample of some new crystally stuff. Nice controlled amount, and no more to fiend :)
 
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