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mephedrone long term negative effects progress reports

Heroic said:
^That's somewhat disturbing, but even small differences can make a, well, difference. Not saying it isn't true though.

What I've noticed is the light-headedness and heart racing out of nowhere. But still I can't attribute all of it to mephedrone in specific, since I was abusing both MDMA and street amphetamine at that period. No good either way.

Months after, I feel normal. And it feels weird.
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I did MDMA the other night, then some mephedrone throughout the next day. Eventually was getting weird light-headed mini waves of energy/rushes.

Huh.
 
Eventually was getting weird light-headed mini waves of energy/rushes.
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Did you eat anything during your little binge? Sounds to me like your blood sugar was so low you couldn't maintain a stable blood pressure.

"Light headed mini waves of energy" are usually a sign of e.g. postural hypotension or acute vasodilation associated with, for instance, cannabis consumption (causing "rushes" etc). In more severe cases they lead to whiteouts/fainting.
 
I tried to eat. Didn't manage much.


This was my first time trying mephedrone. Seemed alright, kind of an enjoyable stim by my standards. Didn't do more than 500-600mg over the night via repeated rectal doses. Would maybe try it once more. Not too fond of some of the possible metabolites and neurotoxicity I've been reading about.
 
Aren't alpha-alkyl halides, fluorides excluded, being such a molecular thylacoleo of the halogen world, and with such a death-grip formed by the C-F bond, are as sekio said alkylating agents, and worse, scarily close to nitrogen mustards?

http://en.wikipedia.org/wiki/Chlormethiazole Even this, an alky terminal ethyl chloride is pretty scary looking in a bioactive molecule used as a medication. It looks carcinogenic, or hepatotoxic. Yet apparently via cytochrome P450-2e1 acts to counteract oxidative EtOH induced stress by inhibitor at this antitarget.

How does this occur? acting as a scavenger? does the relocation of beta to alpha carbon chain halide drastically decrease alkylating, mustard agent type potential? I thought the opposite was true for at least the SAR of nitrogen mustards.

Chlormethiazole does work wonders for seizures though, almost completely suppresses my myoclonic seizures.
 
Primary alkyl halides are reactive, sure, but they aren't anything like nitrogen mustards. Especially the larger alkyl groups.

Nitrogen and sulfur mustards are especially toxic because the presence of a tertiary amine or sulfide can make a reactive intermediate. Plain old alkyl halides need a bit of effort to make them react.

Also, primary alkyl halides are the most stable. Stability is usually F >>> Cl >> Br > I and reactivity goes the opposite way.
 
Yes, I know. IIRC the vesicant properties of sulfur, nitrogen and oxygen mustards depend on being able to produce a highly reactive cyclic onium ion that can alkylate DNA and other tissue left right and center.
 
MeDieViL said:
Its clear that the blue knees have nothing to do with vasoconstriction as confirmed by hospitals, it looks like exactly like lupus, i wonder wheter it brings out underlying lupus (wich flephedrone did for me, witch as result that every stim brings up a flare up) or wheter its specific drug induced lupus that only occurs with meph and resolved after a weeks.

There are some indications that benzo's can reverse lupus, this is confirmed by me and a few other anecdotal reports as they allow the body to deactivity the excessive immume cells, after taking seroquel i noticed that benzo's did not help (it causes drug induced lupus) and further research indicates its indeed caused by a differened mechanism.
In my experience quercetine dramatically reduces the lupus i get from stims too so thats worth a try.
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I know this is an old post but.. no way..

I experience blue / purple knees on most stimulants but only after i've been up for 2 or more days.. My experience of purple knees sounds nothing like lupas.. I get none of the lupas symptoms.. It's clearly a circulatory issue.
 
rickolasnice said:
I know this is an old post but.. no way..

I experience blue / purple knees on most stimulants but only after i've been up for 2 or more days.. My experience of purple knees sounds nothing like lupas.. I get none of the lupas symptoms.. It's clearly a circulatory issue.
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MeDieViL is no fan of http://en.wikipedia.org/wiki/Occam's_razor thought you would have noticed by now

what i mean is its not enough to have a simple obvious explanation (vassoconstriction), a far more extreme one must be concocted though i would love to measure oxygen saturation when someone has had a three day meph binge as breathlessness was a huge syptom of mine. my guess is it would be abnormally low. am i a hypocrite? hehehehehe...
 
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Im not referring to the normal vasoconstriction after a amp binge wich i get too, i refer to hospitalised ppl where no oxygen issues are found with semi permanent blue knees after taking mephedrone, should have been more clear.

^^Are your knees still blue? well thats why you had vasoconstriction otherwise it wouldnt make sense, thats all im saying
 
I'm really not surprised that people that people are having such negative effects to drone by looking at the posts on the thread, I mean weekly binges of 2-3 days is brain numbingly stupid. I use drone occasionally and have had no negative effects other than the day proceeding. I treat drone like MDMA and leave month gaps between sessions, 3 weeks minimum, and this isn't every month, or every three weeks. I get really high quality drone and use between 300-600mg over a 10-12 hour session. I know how moreish it is and that is why I never buy too much at once and by the time we have run out it is 6 in the morning and a stupid time to call our guy. When I start coming down (due to it all being used) I crave more, but unlike a lot of people on this thread I have self control. Deal with the comedown, a few beers a bit of weed and a cup of tea and the craving stops and sleeping becomes a possibility. Also when the comedown is in full swing the next day I treat it just like I do on a MDMA comedown, I eat as soon as I get up, which I know is the last thing you wanna do on drone or md, but it really sorts you out, I stay hydrated and stay active, by doing this my drone comedowns only last until mid afternoon (same with md). What am really getting at is if you use it responsibly and have some self control, it really isn't that bad.
 
Yeah...everyone here knows this. The question is, why does mephedrone have a set of unique after-effects when compared to other stimulants used in excess?

ebola
 
ebola? said:
Yeah...everyone here knows this. The question is, why does mephedrone have a set of unique after-effects when compared to other stimulants used in excess?

ebola
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Yes I know, but a lot of people are acknowledging the unique after effects from excess use and therefore concluding that people should stay away from it entirely. I have a friend who takes way too much of this stuff and the effects on occasion have been horrible, anyone who has done or is doing drone in excess needs to kick it. My scientific ability is terrible so I can't really go into that. However if this is any help a lot of the mental effects excess drone use has had on my friend are similar to excess use of mdma. The same friend went on a week long binge on mdma, which is foolish I know. These effects being depression (as severe as threatening suicide), inability to feel happy and a self destructive attitude. The mental effects on my friend have been much more severe than the physical ones, he has suffered from discoloured joints, and weight loss, but the mental effects seem much more severe on his account. This is the only reason I was pointing out/recommending treating drone like MDMA if people are going to use it.
 
I'm reckon even without obvious health risks (& I'd dispute that), with a drug as compulsive as Mephedrone, the "stay away entirely" advice is pretty good advice.
 
Si Ingwe said:
I'm reckon even without obvious health risks (& I'd dispute that), with a drug as compulsive as Mephedrone, the "stay away entirely" advice is pretty good advice.
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For some I would completely agree, but for people who have used other substances and found it easy to keep the usage of these other substances in moderation the 'stay away completely' advice is maybe a bit too forward. I would never recommend drone being a first stimulant for somebody to try, it was my first, but thankfully I haven't got an addictive personality when it comes to drugs and alcohol.
 
but I am afraid that describes my pre-meph drugs life perfectly. I was convinced I did not have an adictive personality. I had no compulsion to use ANY drug I ever came across regularly until I came across Meph. I wont ever take it again!
 
MeDieViL said:
Im not referring to the normal vasoconstriction after a amp binge wich i get too, i refer to hospitalised ppl where no oxygen issues are found with semi permanent blue knees after taking mephedrone, should have been more clear.

^^Are your knees still blue? well thats why you had vasoconstriction otherwise it wouldnt make sense, thats all im saying
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no that resolved itself when the drugs effect wore off.

other people i know had it resolve as well.

^^ meph is the most addictive drug i have ever tried and it really is bad for you
 
I know this thread is old but it seems somewhat active still.

Had about 1-2g to myself in one night and my friend had about 3-6g spread across a couple days.

No side effects that I've never seen before with other drugs, just slight shallow breath, dilated pupils, sweats, cold, and the fucking pain from snorting it haha, except I was smoking MPA with weed (legal mdma) yeah I know it's BS but it's all we had and I was fine, it was a weird mix because I don't know if the feed was being intensified by this legal MDMA or what and I was also told not to smoke weed with meph but again, no issues.

Going to sleep was a bit weird and I suppose I was seeing weird stuff in my head.

But it's been a couple weeks now and I find that I'm not as hungry as I usually am, although I haven't been to the gym in maybe 2 weeks so that May have something to do with it because I'm used to getting hungry from my workouts.
 
so whats the consensus, it's less neurotoxic than MDMA? worse for you than amphetamine? methamphetamine?

fun?
 
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