I don't think methadone should be grouped with buprenorphine. Mostly because I'd never try methadone. Methadone has NMDA antagonism with full mu-agonism, whereas buprenorphine is a partial mu-agonist and has a lot of other specific opiate activity, and is a better mu-opiate agonist in the form of its metabolite norbuprenorphine. I really think methadone and Suboxone/Subutex should have their own prefixes each.
Some might say they both should be categorized together because they're both maintenance drugs, but both methadone and buprenorphine have been and still are available for pain relief. That's just my opinion, I'd like to hear people's responses as to why methadone and buprenorphine should still be categorized together despite this.
Thats why.. The fact that they can be used for pain relief doesn't change the fact that most people want to research them both primarily for maintenance.
Prefixes are all about organization.. All that science concerning the differences between the two isn't understood by the bulk of new (or even many existing) users, so when discussing them strictly looking at the best way to organize, I don't see how any of that is really relevant.
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i still think they serve a visual purpose though, its helps different things stand out for me. itll take some time for everyone to fully adjust to the visual aspect.