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Melatonin as a precursor for 5-MeO RC's?

H

Hekog

Bluelighter
Joined
Nov 14, 2006
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15
Hello there;

I must admit this is probably a silly question that I'll probably be able to answer in a year or two, but not quite yet, I'm only in the first semester of organic, heh. I only know very basic reactions so far. I'm also not entirely familiar with various methods of synthesis actually used to make the various 5-MeO substituted RC's.

I tried a search but didn't find anything, so I figured I'd make a thread. Sorry if it's a more common question than I've been lead to believe.

Anyway, given that melatonin is readily available and all, how possible/easy would it be to use it as a precursor for that sort of thing considering you only have to change things around with the amine? As I said, I'm really only familiar with more basic reactions with alkanes and alkenes and alcohols and alkyl halides and stuff, not too familiar with reactions involving amines and what have you.

Yeah, that's about it I guess. Thanks for any help!
 
yeah melatonin is readily available but you would need to extract it from the pills which i think only go up to 5 milligrams each...which to me seems like a major pain in the ass. other than that im pritty sure you could do stuff with the amine. i would rather just start with 5-MeO tryptamine. so the question is what is more difficult comming up with an excuse to buy 5-meo from a vendor or extracting hundreds of bottles of melatonin
 
Too expensive. Better to just start from 5-HTP.
You can/should-be-able-to make 5-MeO-DMT in one reaction with the appropriate methylating reagent.
 
MattPsy said:
Too expensive. Better to just start from 5-HTP.
You can/should-be-able-to make 5-MeO-DMT in one reaction with the appropriate methylating reagent.
Click to expand...

how? 5htp is 5-oh tryptophan. methylation would NN-di or NNN tri methyl 5methoxy tryptophan. carboxylic group still present.
 
You decarboxylate tryptophan and get tryptamine. The decorboxlation procedure was posted here recently.
 
Spearmint. But from tryptamine to anything interesting things gets difficult in terms of getting ahold of proper materials.
 
Dr.Heckyll said:
You decarboxylate tryptophan and get tryptamine. The decorboxlation procedure was posted here recently.
Click to expand...

I am aware of that, I was curious about the magical methylation reaction that could turn 5htp into 5meoDMT in one reaction as was implied by the post.
 
I don't understand this. 100mg of 5-Meo-DMT from Sum Yung Hung Gai in China and shipped express is cheaper than a box of melatonin at Duane Re....oops almost dropped a source there!
 
Oh, three reactions. You remove the quarternary methyl once you do the methylation, forgot which reagent is needed for this, but is probabl; not allowed here aneyays, then do the reduction with LAH. It's not a major though.
 
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