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[Mega]Synthetic Cannabinoid Discussion

WIN-55 "Inhibition of skin tumor growth" Study

I recently came across this paper (http://www.jci.org/articles/view/16116) which details the treatment of a cancerous tumor using a combination of WIN-55,212-2 and JWH-133. The cancerous cells were inhibited from growing. However, this doesn't necessarily mean that, after being metabolized that, the chemical itself isn't carcinogenic.

Does this mean anything? (As far as carcinoginity of the JWH family and other synthetics go?)
 
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so far as I know, there are a few varieties of the jwh "series" that do not have obvious carcinogenic signs in their chemical make up.

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I am feeling a dull pain in what I believe is my left kidney as well. I assume it is my kidney considering there are cannabinoid receptors in the kidney. I had a horrible time with jwh-018 the very first day & kept using due to lack of will power, stupidity, & inability to find substitute chemicals to catch a buzz with. I have been smoking for over a month (I think) daily up to 8 times a day.
 
infiltratah said:
I am feeling a dull pain in what I believe is my left kidney as well. I assume it is my kidney considering there are cannabinoid receptors in the kidney.
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You have cannabinoid receptors in just about every organ, tissue, and cell... what does your kidney have to do with it?
 
maybe you should make sure you don't have a kidney stone....

if anything, your biggest apparent danger is frying the shit out of your CB1 and (mostly) CB2 receptors for a week due to massive dosages.

People do seem to have very odd side effects from this stuff, though.

I'm starting to feel that *a large amount* of symptoms reported are due to people smoking A) To much, or B) cut or diluted product.
 
using the same method i made for evenly spraying jwh018 onto random tea leaves, I just sprayed 150mg/2ml on 7 cigs. If you watched the video I posted, same concept.

I think i shall value them at 1$ a piece and call em dub cigs... you know, for a quick 30 minute trip, then being way to high for 2 hours.

Will report back if there is much success... if there is, I can throw up a few quick pics, it was very easy once you know what you are doing.
 
chainer3k said:
stop buying from that vendor. that's not good purity at all. please tell me you didn't just use google and click on one of the most popular links? cut shit.

and yes, you can just eat it.

and yes, tolerance builds rapidly. It helps to make blends so you stay consistent instead of just dumping powder into a bowl or joint.
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No I bought it off a vendor I'd previously bought phenazepam from and even if that was cut it was still potent.

Now what's interesting is that the pipe arrived today and when heated in that it leaves a clear residue, no colour at all. Was I burning the foil? I am NOT a foil expert by any means.

There was no tolerance though, I didn't really feel anything at first, it's not like I was stoned the first time and kept having to raise the amount to get the same effect. I'm raising the amount to get what I deem to be an actual effect. A mere heavy eyelid is not what I seek.

My taking of phenazepam will limit most effects today, this morning wasn't a good un but it got better or at least more managable. I can't rely on that stuff much longer.
 
So I might start getting better effects now then once the phenazepam is out the way?
 
chainer3k. I was asking if there was a BLEND in the uk that had real effect - Not for a vendor, i am aware of google, which is what threw up numerous jwh sites that i have already looked at.

And the reason i was asking if there was a blend in the uk that worked is 1) because the jwh sites either wont send, or look very dodgy - therefore i either cant use them, or dont want to risk using them. And 2) to avoid wasting my time & money looking for something that may not even be available anymore in the uk.


Coolio...i was looking at blends rather than jwh for the above reasons. Really, buying anything other than ethno's or otc's means you cant really be sure what your getting. Your right about the price issue though
 
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ashesofman said:
Well, that's unfortunate. I've never had any success in achieving effects orally.

I know that JWH's solubility is extremely poor in both water and alcohol, and soluble to an extent in lipid fats. I tried vegetable oil, and olive oil and neither worked. Perhaps the dosage needed to be higher, even though I used 10mg of JWH both times. I figured that would be more than sufficient.

I guess it is extremely soluble in acetone, but I don't really like the idea of consuming acetone.

Has anyone succeeded in dosing JWH orally?
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I have been using 018 orally for several weeks now.

To prepare it I dissolved 500MG JHW-018 powder in 500ml of everclear grain alcohol from a local licqour store.

To do this put the everclear in measuring jug and sit this in a pan of hot water. Add the JWH and stir until it dissolves fully. It will NOT dissolve in vodka! I used everclear 190.

At 1mg or 2mg per ml it is very easy to dose.
For me 2ml of the solution produces very strong effects and lasts for upto 6 hours.

When smoked the effects are much shorter in duration.

Taking this solution orally also produces intense hunger at times.

It does take upto 90 minutes for it to kick in when drank depedning on whether you eat before or after! be very very careful! do not re-dose within 2 hours as you may accidentally take too much.

During first week of use I did accidentally take over 5mg due to redosing and after 2 hours it hit like a hurricane! it was manageable but an extremely intense experience.
 
Burn it up said:
I just made a thread discussing about the carcinogenic properties of JWH-18, taking in account the naphthalene metabolism into epoxides and the quantity of naphthalene ingested when consuming JWH-18: Thoughts on JWH-18 carcinogenicity
They are just my speculations, but I think they are interesting.
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If anyone is really that worried about the naphthalene element.
Both JWH-250 and SR-18 have no naphthyl ring at all.
 
Coolio said:
Any reason you continue to buy these pre-made "smoking blends" instead of making your own for 1/100th the cost?
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Personally, I buy mine because I'm too afraid I would fuck up making my own blends. I do not really have the ability to do so due to my living situation.

Noticing lots of blends starting to come into the stores around my area. All fake K2 so far. Still works though, still prefer Serenity Now to anything else.
 
It's as simple as dissolving JWH-018 in isopropyl alcohol and spraying that on the herb... like washing a window with Windex!
 
MrNice said:
Coolio...i was looking at blends rather than jwh for the above reasons. Really, buying anything other than ethno's or otc's means you cant really be sure what your getting. Your right about the price issue though
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You have NO IDEA what is in the blends. You're not sure what you're getting. Why would you be interested in blends after worrying about knowing for "sure what your getting"??

Synthetic cannabinoids on the other hand, you could certainly know what you're getting.
 
Do U.S. headshops just sell the blends with the stuff sprayed on it or can you actualy buy the jwh powder at them?
 
No idea. Call your local shops and ask.

"Spice" and similar smoking blends are likely illegal according to the FDA and maybe the DEA, as they stated when they raided Bouncing Bear Botanicals and Sacred Journeys in Lawrence, KS... JWH-018 is still legal.
 
phenethylo J said:
Do U.S. headshops just sell the blends with the stuff sprayed on it or can you actualy buy the jwh powder at them?
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I doubt any are actually selling the powder chemical. All the shops around here are just selling the blends (and counterfeits at that). Its pretty similar to what it was like in Europe a few years ago (I was living in the UK when spice first started to come around).
 
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