I have Aesperger's syndrome, well was diagnosed with it in my late-teens after mistakenly being diagnosed ADD and whilst doing loads of drugs, which didn't help me at all to know if I was really an aesperger, but basically as I see it if you read up on the whole authtitstic spectrum thing you could say almost everybody would be Dx'd some kind of xxxxxx syndrome aboarding so many areas and being such a broad spectrum.
There's no medication for Aesperger's each one works his-her way out if you decide to treat it, I ended up scripted loads of benzos a-drugs other gaba-ergics and even anti-psychotics, for related issued and also due to past addiction social anxiety and OCD... anyway I've had my fair share of rolls and powder over the years, I never been into the rave-scene or electronic scene though, I just liked taking MDMA at home on my own or with my homeboy ex-girlfriends listening to loud rock music the most...I timed my last doses of some meds so they wouldn't cancel out the effect of MDMA, for example I didn't take quetiapine for 48 hours and only took 2-4mg clonazepam in the morning I rolled about 12hours prior...I also rolled unexpextedly a few times whilst on my meds and opiates and I noticed a diminished effect, and I always disliked being with more than 2-3 people, I enjoyed the most with someone I knew beforehand who'd know I'd be loved-up in my own way...but then that's vry subjective everyone is loved up their own way but I like to be in control of the setting I roll at, dunno if it's my aesperger or the whole social thing surrounding X, that's why I always have hook ups for acid but never for pills I guess...
I'm kinda old and overdone a lot of drugs and know how they interact with supossed Aesperger's syndromeäs effects, and I'd say if you're on meds and never have taken a SSRI a stimulant nor a psychedelic before MDMA wouldn't be your best choice to start with, but if you plan it out well it can be awesome, don't get me wrong the fact I haven't abused MDMA (mostly because I was on Tramadol for years) as I did with other drugs doesn't mean I don't love it, actually it's one of the few drugs I respect and plan beforehand taking it whilst I could drop 5hits of blotter on my own a thursday evening.
Sorry for the lack of parragraphs, I'm kinda insomniac and with light opiate w-d...I must say weed (which sadly I still smoke on a daily basis, and pretty shitty weed nowadays;( is the worst for someone with aesperger heroin would be a close second, but I was also a daily user, but sporadical MDMA use is fine, just test your pills or get molly if you can...happy rolling and if you're medicated plan it out well.