I absolutely LOVE watching anime (AND reading manga) while Im tripping. More specifically, dissociated! Such a fun and intense experience.
But other than the occasional drinking sake and being drunk, or drugs that SEEM like real drugs that give boosts in ability and energy, there hasnt been any that I have seen.
THOUGH, "Dead Leaves," an anime movie, sure seems like it's made to be watched on drugs, which I did, and freaked out haha.
There's a classic samurai anime thats a bit older (Why cant I think of it's name?) that the rival samurai take a drug that makes it so they feel virtually no pain. But its not based on that nor is it trippy or seem to have any euphoric or psychoactive properties.
So glad to see anime/manga mentioned here haha funny I got so into it after being an adult.
In the manga "Welcome to the N.H.K" a manga about social anxiety and mental illness the main character abuses RC hallucinogens ordered from the internet and also speed. It doesn't play too deep a part of the plot but it's there.
The anime changes this to ginseng or something if I remember right and the hallucinations are changed to just the characters mental illness.
wow I definitely gotta check that one out! Internet RC's, hell yeah! :D haha sounds interesting, though.