Lyrica + phenibut please answer

[sonicwhite]

Ok, guys I need a answer. Is their any cross tolerance with these two? Do they interact with each other or do they cancel out one another?


Just wondering cuz I took a crap load of pregabalin and just took about 500 mg of phenibut.

 

[Keif' Richards]

Cross-tolerance is near complete. I speak purely from experience Sonic my man. Gabapentinoids have seemed to proliferate at a fucking pandemic rate over the past ten years. This isn't such a bad thing (right?) considering they seem to be both quite helpful and relatively safe, even in exponentially extreme dosages. Track down pubmed for at least one reference regarding what would be considered a massive overdose of Pregabalin (Lyrica) with mild, non-life threatening symptoms resolving within several hours.

I'm of the opinion that they are all essentially different forms of delivery for the same drug with the primary differentiating factors being their efficiency.

It's worth noting that in extremely high dosages, a small segment of the population will experience tics, uncontrolled motor activity and such, which can be mitigated by either sitting or laying. Said convulsive activity appears to be completely non-epileptic and also resolves within several hours.

 

[sonicwhite]

I just plugged five 160 capsules. I ate so I saw no need to eat them since eat makes it digest slower thus not getting a rush or anything. I believe these things are powerful drugs. I'm not quite sure what to expect from plugging other than it goes a different way making it hit faster.

My friend is a diebatic and he has some points but I said never again.


Thatnks keif

 

[Kurt Cobain]

Cross-tolerance is near complete. I speak purely from experience Sonic my man. Gabapentinoids have seemed to proliferate at a fucking pandemic rate over the past ten years. This isn't such a bad thing (right?) considering they seem to be both quite helpful and relatively safe, even in exponentially extreme dosages. Track down pubmed for at least one reference regarding what would be considered a massive overdose of Pregabalin (Lyrica) with mild, non-life threatening symptoms resolving within several hours.

I'm of the opinion that they are all essentially different forms of delivery for the same drug with the primary differentiating factors being their efficiency.

It's worth noting that in extremely high dosages, a small segment of the population will experience tics, uncontrolled motor activity and such, which can be mitigated by either sitting or laying. Said convulsive activity appears to be completely non-epileptic and also resolves within several hours.

Are you sure about that? I've heard of people having seizures off of this combination. It could be a paradoxical thing like how lyrica can itself cause seizures.

 

[nato23]

Are you sure about that? I've heard of people having seizures off of this combination. It could be a paradoxical thing like how lyrica can itself cause seizures.

That comment is nearly 10 years old

Phenibut and pregabs both work on gaba-B receptor. A don’t think the combo would cause seizures but they definitely will have cross tolerance.

I’m dependent on pregabalin and can only get 300mgs but I’m going to see if phenibut can help me wean from gaba B receptor agonist drugs.

 

[placebonaut]

calcium channel rather than gaba-b.

I love pregab, phenibut is dirty shit, yuck. a taper would be better than swapping for something else, but if you're gonna swap then I'd rather grab some gabapentin rather than phenibut personally

 

[Kurt Cobain]

That comment is nearly 10 years old

Phenibut and pregabs both work on gaba-B receptor. A don’t think the combo would cause seizures but they definitely will have cross tolerance.

I’m dependent on pregabalin and can only get 300mgs but I’m going to see if phenibut can help me wean from gaba B receptor agonist drugs.

I know its old but I also know keif will still reply and I dont have to make a new thread lmfao

Its reportedly pretty common to have a seizure on this combo if you go by some of the anecdotal reports admittedly most were probably dosing very high on both and would yhe cross tolerance not also mean dependancy as well? Most gabaergics do the same shit just with a different level of efficacy

 

[nato23]

calcium channel rather than gaba-b.

I love pregab, phenibut is dirty shit, yuck. a taper would be better than swapping for something else, but if you're gonna swap then I'd rather grab some gabapentin rather than phenibut personally

yeah, just read up on the pharmacology.

Phenibut does have that dirty feeling about it but it made me upbeat and happy. And made me productive, but anxiety disappeared. - and been a single man it made me get more girls than i would have normally. I remember travelling 4 hours up and down the country for some girl. I remember the drive, I had a shit load of phenibut that morning. I was blasting the tunes. Probably one of the the few times a remember being happy

 

[nato23]

I know its old but I also know keif will still reply and I dont have to make a new thread lmfao

Its reportedly pretty common to have a seizure on this combo if you go by some of the anecdotal reports admittedly most were probably dosing very high on both and would yhe cross tolerance not also mean dependancy as well? Most gabaergics do the same shit just with a different level of efficacy

Ohh. Fair enough

Yeah just the lowest pregabalin pills I can get is 300mg, splitting capsules will just be stupid.
With phenibut powder I just think I’ll be able to taper off gaba B substances.

Then I can tackle the benzo and opioid (buprenorphine/subtex) dependency.