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Lysergamides LSI, Ancient LSD, Secret of the Eleusis Kykeon and Vedic SOMA

xdrc said:
What compound is Nichols trying to make? The adduct or the alkylamide?
Click to expand...
Says he wants to do both. Make the condensation product with Lysergamide (That is just LSA correct?) but then says also want to make the alkylamine with isovalerAMINE and Lysergic Acid. I hadn't heard of isovaleramine but is 3-methylbutanamide and comes from valerian root

Dude I'm especially skeptical about the condensation product not that I even know exactly what that structure would look like. Wouldn't it look like Cinnamylidene-bislysergamide sort of and create a dimer type compound? With LSD's very very specific structure determining the manner in how it binds to the 5HT2a

This is the structure of the adduct (pretty sure). Excuse the shitty drawing, just seems unlikely that a molecule thats 2x as big would wanna wiggle into receptor the same way but what do i know? Im no pharmacologist



Nichols also said he was NOT impressed with the book just fyi
 
Also here is Stahls interview with McKenna starting right where he talks very dubious chemistry.



I haven't read the book (I'm not personally planning on it but all this weird shit kind of makes me want to) but I'm not particularly impressed with the interview. I kinda feel bad for McKenna.. Stahl stumbles around quite a bit in his talk, but Dennis doesn't really have the chemistry background to refute it. I still think the paper describing and proving that refluxing ground ergot with lye to break the toxic ergopeptides into LSA is 10,000x more plausible then the adduct theory. . Both the technology and material were available to the greeks as the mesopotamians were distilling as early as 1300 bc. Like I said, I invite you to explore the 3 links that I posted above. Both on the nexus and shroomery they really tear into the theory.

www.nature.com

Investigating the psychedelic hypothesis of kykeon, the sacred elixir of the Eleusinian Mysteries - Scientific Reports

This study revisits the hypothesis that Claviceps purpurea (Fr.) Tul., a fungus infecting cereals and producing ergot alkaloids (EAs), was the psychedelic agent in kykeon, the sacred elixir of the Eleusinian Mysteries. Although archaeological evidence supports this link, experimental data...
www.nature.com www.nature.com
 
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