Low doses of psychedelics for extra energy and as a motivational boost

[red22]

LSD microdoses don't seem to play well with me. They make me irritable and impatient with other people. Green morning glory seeds, however, seem to boost my mood, but do nothing for my focus or productivity.

I found MG seeds to be much more usable on frequent basis because with LSD, the tolerance of the first day eats up the rest of the days.

LSD has a unique mechanism that causes tolerance to spike massively after a single dose, that being that the molecules effectively bind permanently to the 5ht2a receptors which forces the brain to destroy them and replace them over the course of a week.

magistrate101, https://www.reddit.com/r/RationalPsychonaut/s/MnRxPGV6K5

And even though LSA (and/or whatever else in the seeds works) isn't as psychedelic as LSD, it has a unique secondary effect that some people prefer.

“A substance very closely related to LSD, the monoethylamide of lysergic acid (LAE-32), in which an ethyl group is replaced by a hydrogen atom on the diethylamide residue of LSD, proved to be some ten times less psychoactive than LSD. The hallucinogenic effect is also qualitatively different: it is characterized by a narcotic component. This narcotic effect is yet more pronounced in lysergic acid amide (LA-111), in which both ethyl groups of LSD are displaced by hydrogen atoms. These effects, which I established in comparative self-experiments with LA-111 and LAE-32, were corroborated by subsequent clinical investigations.”

Albert Hofmann. LSD: My Problem Child (1979), 3. Chemical Modifications of LSD (More info about LAE-32, for those interested.)


“The slight difference in chemical structure between the [ololiuhqui] constituents and LSD is very significant with regard to hallucinogenic acitivity. The effective oral dose in man of LSD is 0.05 mg; this compound is thus about 50 to 100 times more active than lysergic acid amide, which is active in doses of 2 to 5 mg. Furthermore there is not only a quantitative difference between the principles of [Ipomoea tricolor] and Turbina corymbosa and LSD; there is likewise a qualitative one, LSD being a very specific hallucinogen, whereas the psychic effects of lysergic acid amide and the total alkaloids of these two plants are characterized by a pronounced narcotic component (Hofmann, 1968).”

[Hofmann, A.]: Psychotomimetic agents. In Burger, A. (Ed.): Chemical Constitution and Pharmacodynamic Action, 2nd ed., New York, M. Dekker, 1968, 169–235.

The Botany and Chemistry of Hallucinogens. Schultes, R.E., Hofmann, A. (1973). Charles Thomas, Springfield, IL, p. 252


Seems like LAE-32 is the perfect middle ground between LSD and LSA.


There is an RC chemist/vendor who synthesized LSA and is selling it at the equivalent of $**NO PRICE DISCUSSION PLEASE** a tab. LSA isn't controlled in Canada, and he's only willing to ship it within Canada and to other countries where it isn't controlled. He also synthesized methylergonovine, an analog of ergonovine, another chem in the seeds, which is also known as lysergic acid hydroxymethylethylamide.

 

[emkee_reinvented]

^tryptamines tend to store better in PG than ethanol/vodka in my experience but I've only tried with 4-subs. They degrade in PG too, but slower.

I think DOC could have huge potential in low doses as an alternative to stimulants for ADHD. If I ever find myself with a reliable connect I'll certainly try it in this fashion. DOM too.

Today took a tenth of a blotter about 0.2mg DOC, after a night of insomnia! No psychedelic or stimulating effects noticed, just feel sleepy, which is logic after skipping a night. But it didnt bother me doing things so no negativ effects noticed. it might even encouraged me to do it?

But feeling anything like you normally would is altered after not sleeping.

 

[Achten]

I hear ya !

I love microdosing. I use aMT (2,5-7,5mg) DOC (0,1-0,2mg) MAL (5-7,5mg) and 2c-E (1-2mg).

I don't really notice tolerance when dosing weekly. I skip a week or two when i take a decent trip.

 

[Shinji Ikari]

Today took a tenth of a blotter about 0.2mg DOC, after a night of insomnia! No psychedelic or stimulating effects noticed, just feel sleepy, which is logic after skipping a night. But it didnt bother me doing things so no negativ effects noticed. it might even encouraged me to do it?

But feeling anything like you normally would is altered after not sleeping.

Any different now? I've heard DOx come on sloooooooooooow. Might be worth making a volumetric solution too incase the blotter has hot (or cold) spots.

Tbf if I'd been up all night I think I'd be too off base to notice a microdose myself.

 

[emkee_reinvented]

If it was laid even, was an assumption.
How stable is DOC, pretty stable right. Not it would lose potency like LSD would in water.

So it was testing the waters on a totally onlogical moment, it was in me before I woke.
If I woke that day, seemed like a dream, but at least DOC and Amphetamins dont bite each other.
At least not as combo ing it with LSD, which seems you have leave the meds.

aMT is the most known for interaction and has some MAO-i activity. So actually the most tricky of the 3.
It does seem promising, as its working not quite the same as the dose of that is more a low/ medical dose.
Not really a microdose as the Russian Indopan contain either 5/ 10 mg 1 a day.

Keep you updated, but first taming that insomnia, shitty condition that can kiss my .
2 days 5 hours sleep, = emoticon, HellMo.

 

[perpetualdawn]

There is an RC chemist/vendor who synthesized LSA and is selling it at the equivalent of $45 a tab. LSA isn't controlled in Canada, and he's only willing to ship it within Canada and to other countries where it isn't controlled. He also synthesized methylergonovine, an analog of ergonovine, another chem in the seeds, which is also known as lysergic acid hydroxymethylethylamide.

They have a very interesting and exotic array of lysergamides and other chems, wow!

 

[red22]

They have a very interesting and exotic array of lysergamides and other chems, wow!

I want someone to try pure LSA at a high dose, to see how good/bad it is. MG seeds are always getting bad reviews, but it would be interesting to see if LSA, itself, is an appreciable psychoactive, without the interference of the other ergot chems. Some people have said that purified extractions of seeds are clean, but it would be nice to have a report about a product that we know is pure. I found a Canadian person on The Shroomery who might be interested and I made a thread asking if people would be willing to chip in $ to cover the inflated cost of the product, and I did find one person who was willing to contribute. So, if you or anyone else would be willing to try this product out, we might be able to subsidize you.

 

[red22]

More strychnine info:

Strychnine and brucine are the most important alkaloids of Nux vomica. Both of them are potent stimulants of the spinal cord. Thus, the most characteristic feature of Nux vomica is to render the reflex center in the central nervous system (CNS) more sensitive to afferent stimuli (McIntosh, 1940). In addition, strychnine and brucine increase the secretion of gastric juices and heighten sensory awareness.

Botany, Phytochemistry, Pharmacology and Toxicity of Strychnos nux-vomica L.: A Review. Guo R, Wang T, Zhou G, Xu M, Yu X, Zhang X, Sui F, Li C, Tang L, Wang Z. Am J Chin Med. 2018;46(1):1-23. doi: 10.1142/S0192415X18500015 (Pharmacological Activity / Stimulant Effects of the Nervous System)

Brucine is dimethoxystrychnine.


Strychnine and brucine although being toxic in nature have remarkable therapeutic action.

TLC Determination of Strychnine and Brucine of Strychnos nux vomica in Ayurveda and Homeopathy Drugs. Rathi A, Srivastava N, Khatoon S, Rawat A. Chromatographia 67(7):607-613, Apr 2008. DOI: 10.1365/s10337-008-0556-z


A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report. Patel K, Laloo D, Singh GK, Gadewar M, Patel DK. Chin J Integr Med. 2017 Jan 24. doi: 10.1007/s11655-016-2514-1


Modern pharmacology studies and clinical practice demonstrate that brucine possesses wide pharmacological activities, such as anti-tumor, anti-inflammatory, analgesic, and the effects on cardiovascular system and nervous system, etc. However, its central nervous system toxicity severely limits its clinical application.

Brucine: A Review of Phytochemistry, Pharmacology, and Toxicology. Lu L, Rui H,Ye W, Jin-Mei J, Hong-Zhuan C, Li-Jun Zhang, Xin L. Frontiers in Pharmacology, vol. 11, 2020. DOI: 10.3389/fphar.2020.00377

 

[red22]

Strychnine is sounding more and more enticing.

Following this trend in France, a company in Miami during the 1960s learned of strychnine’s supposed sexual benefit from the medical writings of the Victorian era. The company, All Products Unlimited, hoped to seize upon the sexual revolution of the 1960s for financial gain by selling an aphrodisiac pill they called Jems. The pill, marketed as a “sex energizer pep tablet for married men and women,” contained a small dose of strychnine.

Following the release of Jems to the general public, All Products Unlimited was sued for mail fraud. The suit was, in fact, not focused toward the inclusion of strychnine in the pill’s formula, but instead was focused upon the false claims of Jems being able to provide sexual benefit to consumers. Upon facing the charges in court, the company decided not to fight it and was swiftly indicted.

[Reference: Kang L, Pedersen N. Quackery: A Brief History of the Worst Ways to Cure Everything. New York, NY: Workman Publishing; 2017.]

Fun Fact: What Benefit Did Victorian Era Physicians Believe Strychnine Could Provide?. Alana Hippensteele, Pharmacy Times, Nov 12, 2020

 

[red22]

It's important for people to appreciate the difference between low dose psychedelics and higher doses in the new era. The microdosing movement is promoting such awareness. I came up with a good analogy for this topic: high doses are like watching a documentary on lions in the wild; low doses are like watching your cats play in your garden.