Low doses of psychedelics for extra energy and as a motivational boost

[rogerjpike]

Hi Im new to this and would like to know how I can source 2-CP or MDNA I live in Northern Ireland part of UK
Please help ?

 

[suture]

You definitely can do it with LSD but it made me way too antsy. However, I battled an amphetamine addiction for a while and doing any stimulants after that (besides pedestrian stuff like coffee and energy drinks) always made me very jittery and paranoid. I did try to do the whole microdosing thing with acid but I found that the stimulating properties put me on edge, I also got very mild visual effects like trails and melting patterns, which would then make me constantly paranoid about whether or not my reality is dissolving. I'd keep thinking 'Am I tripping slightly or am I over analyzing my current reality to the point where it seems unusual?' (A bit like when a word looks really unusual for a few moments if you write it over and over again). After doing this for a while (about 2 weeks or so) and playing this game in my mind over and over I started getting some kind of emotional hormonal unbalance like I was a moody teenager and concluded that microdosing acid was just a waste for me. Felt like I was going insane in so many ways.

I don't get it on shrooms at all but generally with any tryptamines I take I have to take a solid dose or else I get uncomfortable stimulant effects and vasoconstriction. I don't get it/notice it much if I take a big dose.

 

[mission780]

You definitely can do it with LSD but it made me way too antsy. However, I battled an amphetamine addiction for a while and doing any stimulants after that (besides pedestrian stuff like coffee and energy drinks) always made me very jittery and paranoid. I did try to do the whole microdosing thing with acid but I found that the stimulating properties put me on edge, I also got very mild visual effects like trails and melting patterns, which would then make me constantly paranoid about whether or not my reality is dissolving. I'd keep thinking 'Am I tripping slightly or am I over analyzing my current reality to the point where it seems unusual?' (A bit like when a word looks really unusual for a few moments if you write it over and over again). After doing this for a while (about 2 weeks or so) and playing this game in my mind over and over I started getting some kind of emotional hormonal unbalance like I was a moody teenager and concluded that microdosing acid was just a waste for me. Felt like I was going insane in so many ways.

I don't get it on shrooms at all but generally with any tryptamines I take I have to take a solid dose or else I get uncomfortable stimulant effects and vasoconstriction. I don't get it/notice it much if I take a big dose.

How big exactly were your LSD micro-doses? Maybe you took too much.

 

[suture]

How big exactly were your LSD micro-doses? Maybe you took too much.

Not entirely sure, on the internet I'm always very careful with mentioning the size of any LSD dose I have taken as most of the time I just don't trust a dealer to get the exact amount right, or for the chemist to remember/tell the truth about how much is on each tab. Not saying that they are liars, but people get figures wrong, they forget, the truth is stretched etc.

But to answer your question as best I can, at that time I believe I had estimated the blotters were laid about 90ug each and I was doing half a blotter so I'd say my microdoses were about 40-45ug.

 

[mission780]

Not entirely sure, on the internet I'm always very careful with mentioning the size of any LSD dose I have taken as most of the time I just don't trust a dealer to get the exact amount right, or for the chemist to remember/tell the truth about how much is on each tab. Not saying that they are liars, but people get figures wrong, they forget, the truth is stretched etc.

But to answer your question as best I can, at that time I believe I had estimated the blotters were laid about 90ug each and I was doing half a blotter so I'd say my microdoses were about 40-45ug.

40-45ug might have been a bit too much.

I am also careful estimating amount of LSD per blotters, which were about 120ug in my case. From my experience a good nootropic dose for me was 1/8 blotter which is 15ug (3 times less than yours). However 1/4 blotter - 30ug, I would also consider nootropic dose - just stronger and more stimulating.

 

[Phaxius]

I actually just took a dab of "shatter" or butane extracted thc purified to resemble glass. so a little bit of weed is totally an understatement and I probably felt extra lazy due to the mg of xanax I took over the weekend. Overall it was a pretty intense anxiolytic almost to the point of being overwhelming.

and the feeling on the body was as if my insides were made of clouds or pillows

I don't think ill be throwing in the weed or the mushrooms tomorrow haha in stead, some extended release amphetamine.

also, before you guys go crazy with Noopept, it should be noted that you should try to dose as small as you can to get your desired effect according to this

and this

and this guy
fig 1 demonstrates the effect of noopept administration: increasing expression of brain derived neurotrophic factor and nerve growth factor in rat hippocampus. Although what groups acute/chronc administration, etc is not supplied in the figure legend, also a housekeeping gene mRNA expression control would be good, but perhaps this is explained in the article proper.

table 2 shows that relative to saline control, acute noopept administration decreases both BDNF and NGF expression in the cerebral cortex but increases expression in the hippocampus. Additionally, noopept administration continued for 28 days increases BDNF expression but has no significant effect on NGF in the cortex, and again in the hippocampus both BDNF and NGF are increased over 2-fold.

increased mRNA expression is a good indication of increased protein (BDNF, NGF) content; although it is not confirmatory, as translational bottlenecks, increased protein turnover or other factors may be at play.

/qoute

apparently "acute" doses are less effective than small ones?

I believe that what they mean by "accute administration" here is shorter duration of administration vs "chronic administration" being over a long term. The implications here would be that it may initially reduce ngf and bdnf expression in these areas, but that with continued usage will increase expression of these in the same areas. This seems to be in line with the increased efficacy of noopept after you have been taking it for a while.

Even so, I do tend to agree about finding a minimal effective dose and not pushing the envelope with noopept too much, since sometimes at higher doses it can have some side effects (not to mention it's wasteful). Irritability is relatively common with higher doses for some people. This can also be common when someone first starts taking it, or after long breaks but (for me at least) goes away after a few days of taking it. After getting past that stage it seems to have the opposite effect on me, more laid back and definitely a nice cognitive boost. Indeed, it does bare resemblance to low dose psychedelics at times.

On another note, I was thinking of trying low dose doc for occasional cognitive/creative/energy enhancement, as I have heard that it lends itself well to such a thing for some people. Shall report back at some point along such lines.

 

[EarthBounded]

There are a ton of threads on this, bad idea point blank, if you don't believe me go for it.

 

[samm2]

hhhhh

 

[samm2]

Noopept 3 doses throughout the entire day,
Is like a low dose psychedelic by the time the second dose kicks in.

But you can actually feel it healing your brain.

Having used noopept, I find it more calming rather than energizing....but my dosing was rather once per day, when I remebered to use it....

 

[red22]

Yeah, the history of the chemical is really fascinating! It was even used as a performance enhancing substance at times...there's several famous instances of olympic athletes partaking in strychnine use.

It would seem bizarre that a drug such as strychnine, so entrenched in the mind as a deadly poison, would ever be seen as a tonic and pick-me-up, yet that is precisely how it was viewed until the beginning of the twentieth century. The title character, Dr. Griffin, in H. G. Wells’s novel The Invisible Man, “found strychnine to be immensely beneficial,” as Wells writes: “Griffin had a little breakdown. He started to have nightmares and was no longer interested in his work. But he took some strychnine and felt energized.” ...

A Brief History of Strychnine, the Poison of Choice for Agatha Christie, Arthur Conan Doyle, and Scores More—but Why? Neil Bradbury, crimereads.com, Feb 10, 2022

 

[red22]

The analog, brucine, was even passed off as amphetamine at one point, according to the former director of a Florida drug testing program:

"I also recall that there was a time when "white crosses" were analyzed to be brucine rather than amphetamine."

George Root, Oct 20, 1994. alt.drugs post (UseNet), 'Re: What are the different kinds of LSD?'. Seen at the bottom of this page: Myths: Strychnine in LSD? Lamont Granquist, 1994. https://www.erowid.org/chemicals/lsd/lsd_myth5.shtml

Interestingly, brucine is stated to be less toxic than strychnine:

"Strychni semen, a herb also known as “maqianzi” in traditional Chinese medicine (TCM), also contains strychnine together with its less toxic analog, brucine."

Strychnine poisoning due to traditional Chinese medicine: a case series. Tong HF, Chan CY, Ng SW, Mak TWL. F1000Res. 2021 Dec 17;10:924. doi: 10.12688/f1000research.73072.2 (Background)


Possible origin of strychnine's association with LSD:

THERE are two stages in the physiological effects that result from eating peyote. First, the strychnine‐like alkaloids in the cactus give a feeling of excitement and exhilaration like that induced by strong coffee. The face becomes flushed, the pupils dilate and the person tends to be talkative, light ‐ headed and wakeful. (These alkaloids have been experimented with in pure form because of a possibility that they might be useful in treatment of heart disease.)

The ‘Diabolic Root’. Weston La Barre, Nov. 1, 1964, The New York Times

Strychnine is an indole alkaloid,[1] like LSD and psilocybin, which are related to mescaline. And mescaline is structurally and effectually similar to amphetamine (effectually, only in high doses), and also contains other related chems, which may be more amphetamine-like, so given the loose structural similarity of these chems to strychnine and given strychnine's reputed amphetamine effect, the description in this news article isn't completely inaccurate. Back then, strychnine was certainly more familiar than mescaline,[2] and given the fact that, as stated above, it had been given to several Olympic athletes (such as Thomas Hicks[3]), it's reasonable to assume that a researcher who had tried strychnine tried peyote and made the "connection".


[1] "Strychnine—a complex monoterpene indole alkaloid..."

Biosynthesis of strychnine. Hong, B., Grzech, D., Caputi, L. et al. Nature 607, 617–622 (2022). DOI: 10.1038/s41586-022-04950-4

[2] It helped chemists develop total synthesis principles:

Is There No End to the Total Syntheses of Strychnine? Lessons Learned in Strategy and Tactics in Total Synthesis. Cannon JS, Overman LE. Angwandte Chemie, 51(18), 4288-4311, Apr 2012. DOI: 10.1002/anie.201107385

[3] Marathon madness. Pain, Stephanie (August 7, 2004). New Scientist. No. 2459, 46-7.

"Two doses of 1/60th grain amounts to 2 milligrams of strychnine which is enough to produce clinical symptoms of poisoning."

 

[emkee_reinvented]

I suppose low dose AMT could work for this, as in 3-7mg oral, or 1-3mg smoked.
5MeO-MiPT @ 1-2mg is "kinda" similar, but much shorter lasting

I'm going to try some low dose 2C-E the next few weeks.

So there might be some use for my aMT-freebase after all

The Russian Indopan (brandname) dose was 5/ 10 mg a day. Maybe its degraded or inactive.
I ll upload a pick for the fun and science kick. As this is like an antique for a RC.
The first ones bought from Canada, right at the beginning of that internet fueled psychedelic revolution.

[url=https://postimg.cc/9RGcqk9h][/URL]

Got it, and it looks surpringly good, been in the fridge a lot of years, then kept dark and cool for over 10 years. Probably its 25 years old. The sticker and bag are more degraded then the powder. Still looks the same, slightly yellow, its hasnt turned brown . Less smelly then it used too. And should have been kept in a glass container. Its still in the plastic bag it was packaged in.

Allready took my ADHD meds so a trial today is not a option. But a oppertunity wil come and I ll report my experience. Especially the previous medical use in Russia gives it some credibility on its effects.

If i titrate up, a microdose will be the start. Wonder where, if there is a positiv effect, it starts.
Starting at 3 mg. maybe going up to 7/ 10 mg max. Assuming its hasnt become inactive!

 

[emkee_reinvented]

Anyway, on topic... I've used aMT a couple of times in this fashion (very low dose I mean), and found it worked well for this purpose. Makes sense when you think how it was used in soviet states. I however am always fighting temptation to take it to the next level, but I think that's just me. Something to work on there...

Your the second mentioning aMT, just reacted on it as i still have a bag. Laying being useless because as recreational or psychedelic drug it just not threat me well.

So fighting temptation will not pose a problem for me. aMT and all Tryptamines share this. But its the lenght that does it which it shares with DOC a Phenethylamine, way different class. Which like the Tryptamines dont agree with me. Only (on to do list) Mescaline and 2C-T2 seem ok.

The rest torture. But microsing them might make them useful.

 

[Shinji Ikari]

It would seem bizarre that a drug such as strychnine, so entrenched in the mind as a deadly poison, would ever be seen as a tonic and pick-me-up, yet that is precisely how it was viewed until the beginning of the twentieth century. The title character, Dr. Griffin, in H. G. Wells’s novel The Invisible Man, “found strychnine to be immensely beneficial,” as Wells writes: “Griffin had a little breakdown. He started to have nightmares and was no longer interested in his work. But he took some strychnine and felt energized.” ...

A Brief History of Strychnine, the Poison of Choice for Agatha Christie, Arthur Conan Doyle, and Scores More—but Why? Neil Bradbury, crimereads.com, Feb 10, 2022

I watched an episode of Father Brown yesterday which featured strychnine as both a performance enhancer and murder weapon.

Old thread but seeing as we're here anyway, I've been regularly micro/mini dosing for a few years. Low dose LSD (C20ug) is absolute magic for mood and productivity enhancement. I haven't found psilocybin or 2cb to be particularly helpful.

I've been taking 50mg of mescaline every morning this week which I'll probably have some thoughts on in the near future.

 

[Pfafffed]

LSD microdoses don't seem to play well with me. They make me irritable and impatient with other people. Green morning glory seeds, however, seem to boost my mood, but do nothing for my focus or productivity. I could definitely see microdosing MAL or mescaline, but have only done it once.

 

[emkee_reinvented]

LSD microdoses don't seem to play well with me. They make me irritable and impatient with other people. Green morning glory seeds, however, seem to boost my mood, but do nothing for my focus or productivity. I could definitely see microdosing MAL or mescaline, but have only done it once.

LSD Microdosed made you like how I am before I ve taken anything. About 1+ hour after waking. Slow runner, never had that, though i loved rest in the morning as kid.

So after deciding trying it. Next step is which substance, at disposal are LSD-analoques, DOC and aMT.
Dosage, how many times a week.
After trying the single substances, very curious to the effect of a microdose. essentially my ADHD meds are (maybe even ultra) low dosed stimulants (not micro but very far from a recreational dose).
The dose is basickly unnoticeable. But during the microdosing I am not taking my meds.

Also thinking about how cycling the different classes would be, lI have the three main ones so why not.
If it falls good! what only doing it will reveal.
One thing what seems unneeded/ risky is taking it daily, a few times a week seems reasonable.

 

[Shinji Ikari]

LSD microdoses don't seem to play well with me. They make me irritable and impatient with other people. Green morning glory seeds, however, seem to boost my mood, but do nothing for my focus or productivity. I could definitely see microdosing MAL or mescaline, but have only done it once.

Main problem using mescaline is it's hideously expensive unless you have cacti kicking around the house. I'm using synthetic mescaline though so it's working out at like £3 a day for a microdose.

I was about to say that makes it prohibitively expensive for long term use but I suppose that's still cheaper than a coffee these days

How were you dosing the LSD out of curiosity? Do you think dose could have been a factor in the negative affects you experienced it is that just you and LSD?

 

[emkee_reinvented]

Mainly the focus of micro dosing moved from the Lysergics to aMT or DOC.
From 1 DOC blot i have prepared 10 0.2 mg doses, which i could halve to be safe.
In case of bad laid sheets with hotspots.

aMT is a bit difficult as my digi scale status atm is:
Or was destroyed during my last seizure.
Or the battery's are just dead after 15 years of use.

So after a restart of the scale and it fails, whats a safe dilutent for aMT-freebase.
For volumetric measuring, my the 2-nd option. So safe for aMT and for humans to.
Bit of Vodka i thought, so there is at least 60 percent water in it.
Will the water degrade my aMT?

 

[Shinji Ikari]

^tryptamines tend to store better in PG than ethanol/vodka in my experience but I've only tried with 4-subs. They degrade in PG too, but slower.

I think DOC could have huge potential in low doses as an alternative to stimulants for ADHD. If I ever find myself with a reliable connect I'll certainly try it in this fashion. DOM too.

 

[pupnik]

alternating 1gm shroom and 20ug lsd works for me, they hit the receptors at different levels, so that tolerance is less of a factor at low doses.
one day off, then lsd, then one day off, then shroom, repeat or take an extra day off...
I no longer have a day job, and seldom have to drive a car.
we keep the place spotless. A good baseline for creative projects (art and something like music using a pocket operator and korg sampler), and that changes day to day.