Opioids lofentanyl

[Deleted member 593549]

anyone tried it.

besides mu activity it is a full agonist potent kappa opioid receptor (like saliva).

it is as potent as car fentanyl but what’s the best i improvement about it is that it is long lasting vs most fentanyl analogues:

The intravenous elimination half-life of lofentanil (lofentanal) is approximately 5.5 hours. [1]
Despite a relatively moderate plasma half-life, its clinical duration of action can last 8 hours or longer

fentanyl has ppl dope sick two hours after dosing

lofent sounds like it could be be more practical due to an 8 hour duration. or having to cause such frequent redosing.

but the kappa agonisism sounds super interesting too.

 

[ChemicallyEnhanced]

Fentanyl analogues makes me very weary. What number does this have on the opioid scale?

Also, is it iofentanyl or lofentanyl? Lowercase "l" and uppercase "I" are identical lol

^Yes, the first letter in quotes IS diferrent from the second.

 

[Deleted member 593549]

Fentanyl analogues makes me very weary. What number does this have on the opioid scale?

Also, is it iofentanyl or lofentanyl? Lowercase "l" and uppercase "I" are identical lol

^Yes, the first letter in quotes IS diferrent from the second.

it’s Lofentanyl.

 

[ChemicallyEnhanced]

it’s Lofentanyl.

Haha, thanks

 

[ChemicallyEnhanced]

Oh, fuck, it's a 5000-6000 on the opioid scale (oral morphine being a 1 and fentanyl being a 100)

So it's approx. 50-60 times stronger than fent? How do people even dose that? You'd be down to literal micrograms?

 

[Deleted member 593549]

Oh, fuck, it's a 5000-6000 on the opioid scale (oral morphine being a 1 and fentanyl being a 100)

So it's approx. 50-60 times stronger than fent? How do people even dose that? You'd be down to literal micrograms?

volumetric dosing.

i’m really interested in how the kappa opioid agonism combines with the powerful mu agonism

 

[tryptakid]

Heroin ruined my life just fine and I'm guessing that would be like a 2 on such a scale.

I have no interest in such oblivion anymore. Fentanyl has taken too many friends, loved ones, and people who couldn't resist its pull. They should give lofentanyl to the people who peddle it.

 

[ChemicallyEnhanced]

Heroin ruined my life just fine and I'm guessing that would be like a 2 on such a scale.

I have no interest in such oblivion anymore. Fentanyl has taken too many friends, loved ones, and people who couldn't resist its pull. They should give lofentanyl to the people who peddle it.

Yes, Heroin is a 2.

 

[Halif2]

it's a 5000-6000 on the opioid scale

It seems that prohibition is like trying to lock away a monster whose sustenance is being locked way. Take something as relatively benign as marijuana - all the attempts at suppression have resulted in some monstrous synthetic 'fake weed' substances. Things like MDMB-4en-PINACA are every bit as dangerous as authorities used to pretend that weed was.

Then there are narcotics which have always been dangerous, such as diacetylmorphine (aka heroin). Try to lock it away and eventually we get lofentanyl. They locked up a monitor lizard and ended up with Godzilla.

If heroin was decriminalised and pretty easily available, would lofentanyl have been synthesizsed? Would there have been any demand for it? Or did it just come about as part of a race to create stuff that avoided the law (by being a novel compound not recognised by law) and/or was easier to smuggle?

Anyway, back to sucking on my own spit. Ahh, that's the good stuff.

besides mu activity it is a full agonist potent kappa opioid receptor (like saliva).

 

[Synergist1]

I had 10 grams set aside for after I had a heart transplant, and I knew they planned on sending me home on methadone. I was already on a high dose of methadone when I had a heart attack, which was what damaged my heart needing the transplant. The heart attack. Not the methadone. They discororaged me playing with my dose bc they didn’t want to mistake wd for another heart issue or medication allergy etc. But I wanted off that shit. My wife tossed it when I was hospitalized. I never opened the foil envelope. 10 grams !! That’s very disturbing to me!! I almost divorced her. She could have easily killed her or a maintenance worker, etc. Very dangerous and careless. And I’m still on methadone.

 

[drewbocop]

Oh, fuck, it's a 5000-6000 on the opioid scale (oral morphine being a 1 and fentanyl being a 100)

So it's approx. 50-60 times stronger than fent? How do people even dose that? You'd be down to literal micrograms?

LOL. JESUS CHRIST! Talk about the stuff nightmares are made of.

I had 10 grams set aside for after I had a heart transplant, and I knew they planned on sending me home on methadone. I was already on a high dose of methadone when I had a heart attack, which was what damaged my heart needing the transplant. The heart attack. Not the methadone. They discororaged me playing with my dose bc they didn’t want to mistake wd for another heart issue or medication allergy etc. But I wanted off that shit. My wife tossed it when I was hospitalized. I never opened the foil envelope. 10 grams !! That’s very disturbing to me!! I almost divorced her. She could have easily killed her or a maintenance worker, etc. Very dangerous and careless. And I’m still on methadone.

More dangerous than having 10 grams of it stored in your home with access available to others? Lol

 

[Synergist1]

IT definitely wasnt accessable to others.. Lets say i ran fake plumbing under the sink and up into the bottom of the basin....then if somebody went crazy enough to disassembly fake trap, and reach in and feel envelope.... then more tricks to dissuade....plus its myhome... no kids over ever!!!
... dont think thats accessable yet....it scared the shit out of me... the potency, and 12 hr 1/2 life!!! IM just glad nobody was hurt..
I have noticed that the literature makes carfent out to be nothing but a weapon of mass destuction, yet ive handdled this on a few occasions, and as long as you know what u starting with, its nowheres near the potency listed....
if nobody tries it, nobody knows its actual dose... Carfent had some legs btw

 

[spypilot]

it is as potent as car fentanyl but what’s the best i improvement about it is that it is long lasting vs most fentanyl analogues:

i havent tried lofentanyl but i have done carfentanil
like carfentanyl but longer lasting
yeah im not going near that shit i would not be able to handle it