Opioids lofentanyl

[Dr. John Thackery]

anyone tried it.

besides mu activity it is a full agonist potent kappa opioid receptor (like saliva).

it is as potent as car fentanyl but what’s the best i improvement about it is that it is long lasting vs most fentanyl analogues:

The intravenous elimination half-life of lofentanil (lofentanal) is approximately 5.5 hours. [1]
Despite a relatively moderate plasma half-life, its clinical duration of action can last 8 hours or longer

fentanyl has ppl dope sick two hours after dosing

lofent sounds like it could be be more practical due to an 8 hour duration. or having to cause such frequent redosing.

but the kappa agonisism sounds super interesting too.

 

[ChemicallyEnhanced]

Fentanyl analogues makes me very weary. What number does this have on the opioid scale?

Also, is it iofentanyl or lofentanyl? Lowercase "l" and uppercase "I" are identical lol

^Yes, the first letter in quotes IS diferrent from the second.

 

[Dr. John Thackery]

Fentanyl analogues makes me very weary. What number does this have on the opioid scale?

Also, is it iofentanyl or lofentanyl? Lowercase "l" and uppercase "I" are identical lol

^Yes, the first letter in quotes IS diferrent from the second.

it’s Lofentanyl.

 

[ChemicallyEnhanced]

it’s Lofentanyl.

Haha, thanks

 

[ChemicallyEnhanced]

Oh, fuck, it's a 5000-6000 on the opioid scale (oral morphine being a 1 and fentanyl being a 100)

So it's approx. 50-60 times stronger than fent? How do people even dose that? You'd be down to literal micrograms?

 

[Dr. John Thackery]

Oh, fuck, it's a 5000-6000 on the opioid scale (oral morphine being a 1 and fentanyl being a 100)

So it's approx. 50-60 times stronger than fent? How do people even dose that? You'd be down to literal micrograms?

volumetric dosing.

i’m really interested in how the kappa opioid agonism combines with the powerful mu agonism

 

[tryptakid]

Heroin ruined my life just fine and I'm guessing that would be like a 2 on such a scale.

I have no interest in such oblivion anymore. Fentanyl has taken too many friends, loved ones, and people who couldn't resist its pull. They should give lofentanyl to the people who peddle it.

 

[ChemicallyEnhanced]

Heroin ruined my life just fine and I'm guessing that would be like a 2 on such a scale.

I have no interest in such oblivion anymore. Fentanyl has taken too many friends, loved ones, and people who couldn't resist its pull. They should give lofentanyl to the people who peddle it.

Yes, Heroin is a 2.

 

[Halif2]

it's a 5000-6000 on the opioid scale

It seems that prohibition is like trying to lock away a monster whose sustenance is being locked way. Take something as relatively benign as marijuana - all the attempts at suppression have resulted in some monstrous synthetic 'fake weed' substances. Things like MDMB-4en-PINACA are every bit as dangerous as authorities used to pretend that weed was.

Then there are narcotics which have always been dangerous, such as diacetylmorphine (aka heroin). Try to lock it away and eventually we get lofentanyl. They locked up a monitor lizard and ended up with Godzilla.

If heroin was decriminalised and pretty easily available, would lofentanyl have been synthesizsed? Would there have been any demand for it? Or did it just come about as part of a race to create stuff that avoided the law (by being a novel compound not recognised by law) and/or was easier to smuggle?

Anyway, back to sucking on my own spit. Ahh, that's the good stuff.

besides mu activity it is a full agonist potent kappa opioid receptor (like saliva).