gingerbaker
Bluelighter
- Joined
- Dec 3, 2013
- Messages
- 69
I've been taking kratom 3x daily for a few months for chronic pain, diazepam 5mg BID for anxiety as well as Gabapentin 300mg BID for anxiety.
(This might be better suited for ADD, but I'll let the mods set that straight).
I have been prescribed cyclobenzaprine (Flexeril) for that musculoskeletal pain (10mg, PRN, TID).
Now, it seems that cyclobenzaprine has the risk of Serotonin Syndrome.
1. My main question is what, if any, pharmacological consequences there would be with concurrent administration of Flexeril and Kratom (in addition to 5mg diazepam BID)?
2. Does kratom have any Serotonergic activity? If so, how dangerous would it be with clinical amounts of Flexeril (10mg)?
3. Additionally, I have Promethazine and Hydroxyzine prescribed for insomnia as a PRN and am curious if this would also be worth consideration due to possible anti-cholinergic additive problems.
Also, I've read some that opioids might have some effect on serotonin syndrome although I wonder if that's not the "dumbing down" that they do for those taking Tramadol (which obviously would be of issue, and sadly is my PRN for breakthrough pain).
That being said, if opioids do contribute to risk of SS, than the various opioid agonism of kratom (mu, kappa and delta to my understanding) have any influence on serotonin?
Thank you, I look forward to any responses.
(This might be better suited for ADD, but I'll let the mods set that straight).
I have been prescribed cyclobenzaprine (Flexeril) for that musculoskeletal pain (10mg, PRN, TID).
Now, it seems that cyclobenzaprine has the risk of Serotonin Syndrome.
1. My main question is what, if any, pharmacological consequences there would be with concurrent administration of Flexeril and Kratom (in addition to 5mg diazepam BID)?
2. Does kratom have any Serotonergic activity? If so, how dangerous would it be with clinical amounts of Flexeril (10mg)?
3. Additionally, I have Promethazine and Hydroxyzine prescribed for insomnia as a PRN and am curious if this would also be worth consideration due to possible anti-cholinergic additive problems.
Also, I've read some that opioids might have some effect on serotonin syndrome although I wonder if that's not the "dumbing down" that they do for those taking Tramadol (which obviously would be of issue, and sadly is my PRN for breakthrough pain).
That being said, if opioids do contribute to risk of SS, than the various opioid agonism of kratom (mu, kappa and delta to my understanding) have any influence on serotonin?
Thank you, I look forward to any responses.
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