Ketamine salts solubility

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1,3-BENZODIOXOLE: An Acidic Arene
1,2-methylenedioxybenzene

A 2nd Order (n = 2) Aromatic With 10 Participating p Orbital Electrons.

H(n) = 4(n) + 2
n = 2
H(2) = 4(2) + 2 = 10

 

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How Many Times Have I Been Around?
Recycled Paper Is Paving The Ground.
Yes, She Lives For The Written Word.
And People Come Second Or Possibly Third. Then Page After Page Of Sniping Rage, From An English Poet Or An American Sage. So, Stop Me, O Ho Ho, Stop Me If You Think That You've Heard This One Before. I Still Love You. Yes, I Still Love You. Only Slightly, Only Slightly Less Than I Used To, My Love.

 

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Need to regrow Ate 8 up dendritic connections of your precious brain's dopaminergic neurons? Take between 1.5 and 2.5 thousand grams (kilos) of the all legal PEA over 2 years! I did.

PEA
1-phenyl-2-aminoethane

PEA tastes AFFRIEUX!

 

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The Rime Of The Ancient Mariner by Samuel Taylor Coleridge
IF By Rudyard Kipling
Acquainted With The Night by Robert Frost

 

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TYLENOL (APAP)
4-hydroxy-N-acetylaniline

ASPIRIN
sodium 2-acetoxy-benzoate

ADVIL
sodium 2-(4-isobutyl-phenyl)propionate

GRAPE FLAVOR
2-aminobenzoate

RESVERATROL
(E)-1-(4-hydroxyphenyl)-2-(3,5-dihydroxyphenyl)ethene

2HC=CH2

ETHENE,
a plant Hormone

CH3CH2CH2CH2CH2-OH
AMYL ALCOHOL

 

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DIETHYLORPHENADRINE
N,N-diethylamino-3-oxa-4-phenyl-4-(2-methylphenyl)butane

 

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ZELDA ISO ZOLOFT
Cis-2-methylamino-1-(3,4-dichlorophenyl)tetraline

 

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JWH-073
1-(1-pentylindole-3-yl)-1-(2-methoxyphenyl)methanone

AMP-111
1-(1-pentylindole-3-yl)-1-(2,5-dimethoxy-3,4-methylenedioxyphenyl)methanone

5:42 AM EST, Friday December 30th, 2022 AD. Too Late To Sleep, Too Soon To Rise.

 

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Fluorine Gets A Lot Of Hype For Being Electronegative, But It Lacks The Heavy Atom Effect Which Is Why Oxygen, The 2nd Most EN Element, Beats It Hands Down Pharmacologically.

Oxidation (loss of electrons) Is A Form Of Burning.

Oxygen Is Necessary To Burn Hydrocarbons But Cannot Itself Be Burned.

A Carbon With An Oxygen Attached Has Had Its Energy Lowered Thermodynamically.

Fluorine Is Most Useful If Making Teflon.
4-FA Is Just Aight.

AIGHT
1-(4-fluorophenyl)-2-aminopropane

Though F and O are both very electronegative, Halogens Are Deactivating (miotic) While O is activating (mydriatic).

DOCTOR WHO
1-(4-methoxyphenyl)-2-aminopropane

I only sampled one batch of PMA, but it was so worth it, a pink Superman.

But what about all the youngsters who died from PMA, you shriek?! Chill out. You can die from anything.

The only person I condone Drug use for is myself, and if I petitioned the President for a Schedule I license, he just might grant my wish.

 

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I Have Gained 40 lbs In 2 To 3 Months Of Not Doing ICE Regularly. PHADDEUS!!!

 

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4-pentylmethamphetamine, while not unpleasant, is weak enough to be annoying yet strong enough to overpower 40 mg Of Zyprexa & 600 mg Of Seroquel.

 

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If the clerk at the convenience is that unhappy to be working there so as to be reliably discourteous to customers, then she should just quit.

 

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And, If You Don't Love Me Now, You Will Never Love Me Again! Chains Of Love.

 

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The Only Way Out Of The Constant Samsara Of Endless Births And Rebirths Is Moksha / Nirvana / Liberation.

It's Pretty Clear To Me That People Are Sizeably Miserable Here.

 

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The Drug Dealing Got So Corrupt On So Many, Every Level(s) Even, That They Started Str8 Up Serving Lethal Doses Of Fentanyl, Which Was Never Very Euphoric To Begin With And Which Killed 2 Of My Friends Named Chris And Almost Myself.

 

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ANANDA_AMANDA
N-(4-hydroxyphenyl)lysergamide

BEE_NIGN
1-(2-methoxyphenyl)-2-aminopropane

JUCIFER
1-(2,6-dimethoxyphenyl)-2-aminopropane

BUMBLE_BEE
1-(2,3-methylenedioxy-4,5-methylenedioxyphenyl)-2-aminopropane

 

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YIN_YLANG_YANG_YLANG
N-methyl-2-(2S)-ethylamino-1-phenylpropane

 

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I Have Read That DOA (4-amino-2,5-dimethoxyamphetamine) is inactive, but I still like posting structures, even when their effects if any are unknown.

THE_GRAPE_APE
1-(2-aminophenyl)-1-oxo-2-methylaminopropane

^--Inspired by Grape flavoring, 2-aminobenzoate.

THE_MOTHER_LIQUOR
1-(2-amino-3,4-methylenedioxyphenyl)-2-aminopropane

SWEET_LIKE_LICORICE
1-(6-amino-3,4-methylenedioxyphenyl)-2-aminopropane

Dangerous Like Syphilis!

 

[Fertile]

Talaprevir, Telmisartan, Olmesartan, Losartan, Montelukast, Atorvastatin. What do all of these medications have in common? They violate Lipinski's Rules of 5. Now, why is that SO odd, well because Lipinski and his ego convinced Pfizer not to bother studying any drug that violated his RO5.

It's an excellent rule-of-thumb, but when finally Pfizer changed their opinion, 2 of the successful candidates had been in the Pfizer library for decades with no work carried out because of a rule.

I, for one, would trust it if I totally understood the receptor(s) and binding.... but with many unknowns, it's not possible to stay.

In fact I defeated RO5 myself. Only in a very basic way - by producing a mixed dimer based on the 7-ethynyl homologue of clobazam and the 6-ethynyl homologue of diazepam and a MW over 600, It remains a single chemical throughout ADME. Why? Because I realized and alcohol mimic needed a 1,4-benzo and a 1,5-benzo but it would cost twice as much (at least) to get a licence for 2 drugs--- thus they were joined with a butane-1,4-diol bridge between the 3 positions.

Some messing around with different 1,4 & 1,5-benzodiazepines will be needed but with a MW of 684, it's most certainly active.

It seems that be it a 1,4 or a 1,5, a 7-ethynyl (or 8-ethynyl if their is a 4th ring e.g. alprazolam) then the compounds ARE a5 selective, just like all of the positive effects of alcohol.

I MAY have to go with a bridge with an extra -OH or 2 to lower LogP but other than that, the bridge is known to work. What I REALL:Y seek is more information on etifoxine. I spent weeks looking and the ONLY thing I found was that a '2 chloro increases toxicity and reduces the effects.

I don't know if a '2 substitution of 1,5-benzos has any effects on activity.
8-ARYL-5,6,7,8-TETRAHY DROPYRAZOLO(3,4-b)(1,4)-DIAZEPINE-1H, 4H-5,7-DONES, AND MEDICAMENTSCONTAINING THESE
Rackur et al.
US 4305952A

It would seem so. Column 13 has a table and R6 represents substitution of the benzene ring. With the 1,4-benzodiazepines, '2 bstitution increased activity while 4 substitution produces a compound with peripheral activity so let's look at the '2 substitutions. While differing 2 & 4 substitutions are tried out, only the '2=-chloro & '2-methyl are tested. No logic of what was tested if given BUT...

Consider that methaqualone has a 2'methyl but it's close (I am told) relative is mecloqualone in which the methyl is swapper for a -Cl. At this stage, just an accident.

4,5-DIHYDRO-1,2,4-TRIAZOLO(4,3-A)QUINOXALIN-4-ONES
LOEV B; SUH J T; WILLIAMS B E; GEORGIEV V S
NZ197101A

Gives examples of 1,5-benzodiazepines and examples with triazolo rings. Of course, nothing to say they are highly active in man, but it's well worth knowing what is likely to be a worthwhile modification and what is not.

So anyone with time - I would appreciate someone checking my work.

It all adds up to the ability to more finely tune the final compound. OK, no doubt it will take many attempts, but if the triazolo works, the '2-subsstitution works and a 3-OH (for bridge) ALL work is well worth knowing.