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Ketamine salts solubility

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2,4,6-trinitrotoluene.png


ALFRED_NOBEL
2,4,6-trinitrotoluene

2%2C4%2C6-triamyl-1%2C3%2C5-trinitrobenzene.png


HI_EXPLOSIVE
1,3,5--triamyl--2,4,6-trinitrobenzene
 
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1-phenylguanidine.png


ARG!
1-phenylguanidine

1-(3,4-methylenedioxyphenyl)-3-ethylguanidine.png


MARSHA EMERY
1-(3,4-methylenedioxyphenyl)-3-ethylguanidine
 
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ibb.co

Screenshot-20210707-201531 hosted at ImgBB

Image Screenshot-20210707-201531 hosted on ImgBB
ibb.co ibb.co

LITTERALLY CALL THIS ONE: UTOPIUM

Melanocortin
Orexin
Oxytocin
Gamma secretase
Gaba gamma etc
Monoamine oxidase
Adenosine
Vanilloid receptor
Tadadimtatadam
0.5mg for 7mg PUP FLEX for 0.1mg BREATHY for 2.4mg of my sister's little secret. This one is actually patented by my sister, so we pep it up!
 
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Rectify said:
ARG!
1-phenylguanidine
Click to expand...

1-phenylbiguanides are 5ht-3 subtype selective agonists.

snipped:
It is of note
that the affinities of 3-chlorophenyl- (130) and 2-naphthylgua-
nides (131) which also act as 5-HT3 receptor agonists manifest the
highest (by one or two orders of magnitude) affinities among other
structurally related arylguanides 233 and can thus be regarded as
representatives of a new structural class of serotonin receptor
agonists.
Click to expand...

i think most of small molecule ligands have been done by now.
 
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POSITIVE AFFIRMATION MANTRA TO BRING ABOUT FINANCIAL ABUNDANCE: I Allow Myself To Receive These Messages As I Relax From The Tips Of My Toes To The Hairs On My Head. My Whole Body Relaxes. I Am So Happy & Grateful Now That Money Comes To Me Continuously, In Increasing Quantities, From Many Sources. I Am One With The Infinite Riches Of My Subconscious Mind. It Is My Right To Be Rich, Happy, And Successful. Money Flows To Me Freely, Endlessly, And In Avalanches Of Abundance. I Am Forever Conscious Of My True Worth. I Give My Talents With Love, And I Am Wonderfully Blessed Financially. It Is Amazing. jakeducey.com
 

Latest advances in cannabinoid receptor agonists​


Abstract​

Background: Since the discovery of cannabinoid receptors and their endogenous ligands in early 1990s, the endocannabinoid system has been shown to play a vital role in several pathophysiological processes. It has been targeted for the treatment of several diseases including neurodegenerative diseases (Parkinson's disease, Alzheimer's disease, Huntington's disease and MS), cancer, obesity, inflammatory bowel disease, neuropathic and inflammatory pain. The last decade has witnessed remarkable advances in the development of cannabinergic ligands displaying high selectivity and potency towards two subtypes of cannabinoid receptors, namely CB1 and CB2.
Objective: In this review, we highlight the latest advances made in the development of cannabinoid agonists and summarize recently disclosed, novel chemical scaffolds as CB-selective agonists in patents that appeared during January 2008 - June 2009.
Methods: Data presented here are obtained through the search of PubMed for research articles and reviews, and the website of European patents (http://ep.espacenet.com), SciFinder Scholar and US patents (www.uspto.gov).
Conclusions: Our analysis reveals prolific patenting activity mainly in the CB2 selective agonist area. Limiting the BBB penetrability, thereby, leading to peripherally restricted CB1/CB2 agonists and enhancing CB2-selectivity emerge as likely prerequisites for avoidance of adverse central CB1 mediated side effects.
Click to expand...

pubmed.ncbi.nlm.nih.gov

Latest advances in cannabinoid receptor agonists - PubMed

Our analysis reveals prolific patenting activity mainly in the CB2 selective agonist area. Limiting the BBB penetrability, thereby, leading to peripherally restricted CB1/CB2 agonists and enhancing CB2-selectivity emerge as likely prerequisites for avoidance of adverse central CB1 mediated side...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

drive.google.com

2009 - Latest advances in cannabinoid receptor agonists.pdf

drive.google.com drive.google.com

best paper on the recent ongoing in cannabinoid ligands, lots of interesting structures.
 
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1-(3,4-dichloro-2-methoxyphenyl)-2-amino-1-chloropropane.png


PHISH
1-(3,4-dichloro-2-methoxyphenyl)-2-amino-1-chloropropane

A LIVE ONE

1-(3,4-methylenedioxyphenyl)-2-methylamino-1-(methylthio)propane.png


SADDUCE
1-(3,4-methylenedioxyphenyl)-2-methylamino-1-(methylthio)propane

1-(4-trifluoromethylphenyl)-2-aminopropane.png


PHARISEE
1-(4-trifluoromethylphenyl)-2-aminopropane


1-(4-hydroxyindole-3-yl)-2-aminoethane.png

(

4-HOT
1-(4-hydroxyindole-3-yl)-2-aminoethane
4-HydrOxyTryptamine

1-(2-(methylthio)-3,4-dibromophenyl)-2-methylamino-propane.png


THE_GOOD_SAMARITAN
1-(2-(methylthio)-3,4-dibromophenyl)-2-methylamino-propane

(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane.png


PENICILLIN_M
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane

aka penicillin G methyl ester

so obvious it hurts

penetrates CSF much better than its parent compound, pen G (benzyl penicillin)
 
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(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetoxy)]-4-oxa-1-azabicyclo[3.2.0]heptane.png


FLUFFY_THE_CAT
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetoxy)]-4-oxa-1-azabicyclo[3.2.0]heptane
 
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetoxy)]-4-oxa-1-azabicyclo[3.2.0]heptane.png


FLUFFY_THE_CAT
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetoxy)]-4-oxa-1-azabicyclo[3.2.0]heptane
 
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetoxy)]-4-oxa-bicyclo[3.2.0]heptane.png


Un-SL-ANTIOXIDANT
(2S,5R,6R)-2-carbomethoxy-3,3-dimethyl-7-oxo-6-[(2-phenylacetoxy)]-4-oxa-bicyclo[3.2.0]heptane
 
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