• N&PD Moderators: Skorpio | thegreenhand

Ketamine salts solubility

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1-phenyl-2-methylamino-1-(methylthio)propane.png


ENOS_SONE
1-phenyl-2-methylamino-1-(methylthio)propane

1-phenyl-2-ethylamino-1-(methylthio)propane.png


TONYA_TOYOTA
1-phenyl-2-ethylamino-1-(methylthio)propane

1-phenyl-2-amino-1-(methylthio)propane.png


IDA_OLYMPIAD
1-phenyl-2-amino-1-(methylthio)propane

N-(2,2,2-trifluoroethyl)-1-phenyl-2-aminopropane.png


WIEGEHTS
N-(2,2,2-trifluoroethyl)-1-phenyl-2-aminopropane

N-(2,2,2-trifluoroethyl)-1-(3,4-methylenedioxyphenyl)-2-aminopropane.png


GEGENSIE
N-(2,2,2-trifluoroethyl)-1-(3,4-methylenedioxyphenyl)-2-aminopropane

1-(4-(1,1,1-trifluoro)methyl-(2,6-dimethoxy)phenyl)-2-aminopropane.png


DOTTIE
1-(4-(1,1,1-trifluoro)methyl-(2,6-dimethoxy)phenyl)-2-aminopropane

1-(4-(1,1,1-trifluoromethyl)indole-3-yl)-2-dimethylaminoethane.png


99_LUFT_BALLOONS
1-(4-(1,1,1-trifluoromethyl)indole-3-yl)-2-dimethylaminoethane

N,N-diethyllysergamide.png


SID NEWTON
LSD-025
"acid"

I Took 50 Hits Of Acid Once.

1-(4-trifluoromethylphenyl)-1-oxo-2-methylaminopropane.png


FRED EVANS
1-(4-trifluoromethylphenyl)-1-oxo-2-methylaminopropane

1-(4-trifluoromethylphenyl)-2-aminopropane.png


SAM MCNAIR PENNINGTON
1-(4-trifluoromethylphenyl)-2-aminopropane

CF3CF2-O-CF2CF3 (g)

SLICK_RICK
perfluorodiethylether
 
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HENRY
2-acetoxy-1-(aminocarbonyl)benzene

low abuse potential pain reliever

HENRY: High Earner, Not Rich Yet.

1-(3-methylphenyl)-1-oxo-2-diethylaminopropane.png


MELISSA
1-(3-methylphenyl)-1-oxo-2-diethylaminopropane

1-(4-methylphenyl)-1-oxo-2-diethylaminopropane.png


JOHN
1-(4-methylphenyl)-1-oxo-2-diethylaminopropane

1-(4-methylphenyl)-1-oxo-2-(1-pyrrolidinyl)pentane.png


FRANK
1-(4-methylphenyl)-1-oxo-2-(1-pyrrolidinyl)pentane

Internet's In Effect

1-methyl-2-(6-bromopyridin-3-yl)pyrrolidine.png


VIRGINIA
1-methyl-2-(6-bromopyridin-3-yl)pyrrolidine

Yes, Virginia, There *Is* A Santa Clause!

1-(3-methylphenyl)-1-oxo-2-(1-pyrrolidinyl)-3-phenylpropane.png


SANTA_CLAUSE
1-(3-methylphenyl)-1-oxo-2-(1-pyrrolidinyl)-3-phenylpropane

ALL Have Fallen Short Of The Glory Of God.
 
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There's Methyl And Ethyl, But Butyl Is Feudal.
Same As It Ever Was!

1-(dibutylamino)-2-(indole-3-yl)ethane.png


FRED
1-(dibutylamino)-2-(indole-3-yl)ethane

1-(diethylamino)-2-(5-nitroindole-3-yl)ethane.png


THE_SERPENT
1-(diethylamino)-2-(5-nitroindole-3-yl)ethane

1-(dipropylamino)-2-(4-nitroindole-3-yl)ethane.png


DOCTOR_BOB
1-(dipropylamino)-2-(4-nitroindole-3-yl)ethane

1-(dimethylamino)-2-(4-bromoindole-3-yl)ethane.png


BARNEY
1-(dimethylamino)-2-(4-bromoindole-3-yl)ethane
 
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1-(3,5-dimethoxy-4-pentylphenyl)-2-aminopropane.png


HEAVEN
1-(3,5-dimethoxy-4-pentylphenyl)-2-aminopropane

I Used To Think I Was Jesus. Then They Shot Me In The Head. :/
 
1-(indole-3-yl)-2-amino-2,2-dimethylethane.png


ANN_NAN_ANNA_HANNAH_MONTANA_KARRENINNA
1-(indole-3-yl)-2-amino-2,2-dimethylethane

1-(3,4,5-trimethoxyphenyl)-2-amino-2-methylpropane.png


ROBOCOP
1-(3,4,5-trimethoxyphenyl)-2-amino-2-methylpropane
 
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DMT-DEPOT
10-(3-(2-dimethylaminoethyl)indole-4-yl)decanoate

1x monthly IM depot injection for depression

10-(4-(2-aminopropyl)phenyl)decanoate.png


SLYVANSE-IM
10-(4-(2-aminopropyl)phenyl)decanoate

1x monthly depot injection for adhd/depression
 
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Design, synthesis and pharmacological evaluation of certain GABAB agonists​


Abstract​

Synthesis of (RS)-5-amino-3-aryl (methyl)-pentanoic acid hydrochlorides, 3 aminomethyl-5-chloro-benzoic acid hydrochloride and (RS)-4-amino-3-(4`-ethynyl(iodo)-phenyl)-butanoic acid hydrochlorides have been accomplished. The aim of their synthesis was to evaluate their GABABR agonist activity and to derive a model which will correlate their structure with the observed pEC50. The GABABR agonist activity of the prepared compounds has been determined in functional assay based on calcium measurement in vitro using tsA cells transfected with GABAB1b/GABAB2/Gαq-z5. Reviews on the neurotransmitter receptors (ligand-gated ion channel receptors and G protein-coupled receptors), their agonists and antagonists have been given in the general part of this work. A detailed discussion on the strategy followed for the synthesis of the designed compounds as well as the starting materials and intermediates has been described and illustrated in Schemes 2-6. The synthesized compounds were evaluated for their GABABR agonist activity. Furthermore, these compounds were docked in the available 3D homology model of GABABR using the program FlexiDock implemented in SYBYL software. Subsequently, we derived a predictive model which correlates the experimentally determined pEC50 with the calculated binding energy of certain baclofen analogues and homologues. In addition, we used the program DISCO (DIStance COmparisons) implemented in SYBYL software to find the pharmacophore features of GABAB agonists.

 
1-(2,4,6-trimethylphenyl)-2-aminopropane.png


SPACE CADET
1-(2,4,6-trimethylphenyl)-2-aminopropane

1-(2,5-dimethoxy-4-tert-butylphenyl)-2-aminopropane.png


CLUNKARD
1-(2,5-dimethoxy-4-tert-butylphenyl)-2-aminopropane

(2S)-1-phenyl-2-ethylaminopropane.png


ETH-AMP
recrystallized (2S)-2-ethylamino-1-phenylpropane hydrochloride

^-- What You WANT!

Notice that all the amphetamines are PROpains.


1-(2,3,4,5-tetrachlorophenyl)-2-aminopropane.png


OVERBOARD
1-(2,3,4,5-tetrachlorophenyl)-2-aminopropane

(2S)-2-(2,2-dichloroethylamino)-1-phenylpropane.png


NOVEL-T
(2S)-2-(2,2-dichloroethylamino)-1-phenylpropane

And probably a potent novelty at that.

(1R,2S)-1-phenyl-1-chloro-2-methylaminopropane.png


MODEL_C
beta-chlorinated ephedrine
(1R,2S)-1-phenyl-1-chloro-2-methylaminopropane

(2S)-1-phenyl-2-(hydroxyethylamino)-propane.png


LEKKER
(2S)-1-phenyl-2-(hydroxyethylamino)-propane

a cross between amphetamine & ethyl alcohol, the kind ppl drink

There's Methyl & Ethyl,
But Liquor Is Quicker!


1-(3,4-methylenedioxyphenyl)-2-(2-hydroxyethylamino)propane.png


CONCUPISCENT
1-(3,4-methylenedioxyphenyl)-2-(hydroxyethylamino)-propane

The ecstasy version of lekker.

1-(4-hydroxyphenyl)-1-oxo-(1-hydroxymethylamino)propane-3-ol.png


TRIOLMCAT
1-(4-hydroxyphenyl)-1-oxo-(1-hydroxymethylamino)propane-3-ol

^--Novel Antibiotic loosely based on triamphenicol and methcathinone (MCAT).

(2S)-1-phenyl-2-(1-hydroxymethylamino)propane.png


SKIRT
(2S)-1-phenyl-2-(1-hydroxymethylamino)propane

designed to circumvent current, Draconian anti methamphetamine laws, for a short while perhaps

3-(3,4-diacetoxyphenyl)-4-methyl-5-(dimethylamino)pentane.png


BLUCYNTA
3-(3,4-diacetoxyphenyl)-4-methyl-5-(dimethylamino)pentane

IV opioid
 
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N,N-bis(2-hydroxyethyl)lysergamide.png


JP-0730

N,N-bis(2-hydroxyethyl)lysergamide

because look at anandamide

Is This Compound Active?

FEEDBACK
 
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THE_REAPER
1-(4-(propylthio)phenyl)-2-aminopropane



1-(4-propylphenyl)-2-aminopropane.png


SHOOTING_STAR
1-(4-propylphenyl)-2-aminopropane



1-(5-(propylthio)indole-3-yl)-2-dimethylaminoethane.png


CASEY_CASEM
1-(5-(propylthio)indole-3-yl)-2-dimethylaminoethane

1-(4-(propylthio)indole-3-yl)-2-dimethylaminoethane.png


ED_CHANCE
1-(4-(propylthio)indole-3-yl)-2-dimethylaminoethane

This Isn't Rocket Science.
It's Just Science For Rockets.
 
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1-(4-propoxyphenyl)-2-aminopropane.png


ERIN
1-(4-propoxyphenyl)-2-aminopropane

1-(5-propoxyindole-3-yl)-2-dimethylaminoethane.png


TONY
1-(5-propoxyindole-3-yl)-2-dimethylaminoethane

I Am Multiverse Fluent.
 
(3R)-1-methyl-3-(2-hydroxy-4-(1,1-dimethylnon-1-yl)-6-(methylthio)phenyl)cyclohex-1-ene.png


MICHAEL_MICHEAL_MIKELL
(3R)-1-methyl-3-(2-hydroxy-4-(1,1-dimethylnon-1-yl)-6-(methylthio)phenyl)cyclohex-1-ene

As For Me, I'm Just A Poor Boy From A Rich Family!!!

 
1-(4,4-dibromo-2,5-dioxocyclohex-1-yl)-2-methylaminopropane.png


BEDLAM
1-(4,4-dibromo-2,5-dioxocyclohex-1-yl)-2-methylaminopropane

1-(4-bromo-2,5-dioxocyclohex-3,6-diene-1-yl)-2-methylaminopropane.png


BELLEVUE
1-(4-bromo-2,5-dioxocyclohex-3,6-diene-1-yl)-2-methylaminopropane

There Are 2 Types Of People In This World:

1. Those Who Live In The Institution.
2. Those Who Work At The Institution.
 
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1-phenyl-2-(diethylamino)propane.png


DEA
1-phenyl-2-(diethylamino)propane
N,N-DiEthylAmphetamine

(2R)-1-phenyl-1-ethyl-2-methyl-3-(diethylamino)-3-oxopropane.png


AXL_ROSE
(2R)-1-phenyl-1-ethyl-2-methyl-3-(diethylamino)-3-oxopropane

possible opioid

1-(2-methoxy-4-isopropylphenyl)-2-aminopropane.png


THE_EMINENT_EMINEM
1-(2-methoxy-4-isopropylphenyl)-2-aminopropane

Possible Entactogenic Psychedelic Stimulant inspired by the essential Oil Of Oregano. Marshall Mathers & I are apparently 'variants' of each other.

 
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@Rectify i love some of your ideas! Did you know i recently found a company claiming to sell 2,5-dimethoxy-4-methylaminorex? Can you imagine that as a precursor to 2,5-dimethoxy-4-bromo-4-methylaminorex? The only aminorex I've tried is the 4-MAR analogue of mephedrone, aka 4,4--DMAR. It was freaking amazing! Only did 1g. That drug blew my mind as did 4-MMC which it is a close relative of. Both are beta oxygenated phenethylamines with a para methyl group.


I'm still claiming beta methoxy 4-methylmethamphetamine is one day gonna be the biggest commercial hit i could imagine after comparing 2c-d with BOD. 4-MMC was so good it's now considered a 'new classic' by some and very likely to never, ever, ever stop being manufactured in illicit labs. From what i have read bk-2-cb sounded more like BOB than 2c-b (different duration and effects) so that's one reason that after sampling both 2C-d and BOD i think beta methoxy-4-methylmethamphetamine will be more like it's desmethyl, ketone relative 4-methylmethcathinone. Also, it's unlikely to produce the highly cardiotoxic metabolite 4-methylephedrine. It's also likely to have a longer half life.

Of course beta methoxy MDMA is a possibility just like methylone aka bk-MDMA was. It's likely to be similar! I prefer 4-MMC to bk-MDMA but used to mix them regularly. The
next i am interested in is BM-MDMA beta methoxy or in Shulgin's terminology BOMDMA, or since i prefer 4-mmc to MDMA, BM-4MM or BO-4MM.

I noticed @Rectify posted some beta methylthio compounds. I am truly curious about how active those would be as well. Of course I'd be interested in any possible triple releasing agents or psychedelics that could result from beta methylthio.... of course with beta methylthio straight stimulants are a possibility too.
I firmly believe they will never be able to stop us from rolling and tripping!!!! My philosophy usually is roll/trip on!!
I wish i had the technical knowledge to attempt to synth it myself. The craziest thing I've ever tried to synth myself is methcathinone. It only turned out as snortable crystal once. Every other time the reaction was too warm and got black goo. That shit has to be starting to form ice crystals when you add the KMnO4 or lots of product will be ruined.
Cheers! Keep imagining!
 
Thanks! I found beta-methoxy-methamphetamine to be, well, POWERFUL. Never had beta-methoxy-MDMA, but like you, I would gladly try beta-methoxy-4-MMC!
 
1-(4-isopropyl-3-methoxyphenyl)-2-aminopropane.png


THYME_THYME
1-(4-isopropyl-3-methoxyphenyl)-2-aminopropane (from thymol)

Ask Cyndi Lauper.
 
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