onetwothreefour
Bluelight Crew
i can beat "most painless" and actually give you a *pleasurable* one...like moe and kemical said, a h overdose (i presume, but i've not had it so i couldn't be sure), but then i could think of plenty of other drugs that would probably be quite fun too 
anyway, a nice comfortable method would be the hot bath and slit wrists idea - slowly drift off into sleep whilst simultaneously being overcome with comfort :D

anyway, a nice comfortable method would be the hot bath and slit wrists idea - slowly drift off into sleep whilst simultaneously being overcome with comfort :D