Kratom Is there a way to determine threshold doses for 7-OHM with opioid history ?

[Juicewrldfan]

Yeah I'm up in Cleveland, used to bang around down in CBUS a lot and have hit a lot of shows down there and Legend Valley etc.

And yeah it's whack how they do that, it's one thing if you had died and they were obligated to find justice or something, but to just take advantage of the situation like that is just plain invasion of privacy

lol and I was up doing stims alone for days…do they not know that phone is heavily contaminated…I feel so dirty sharing that lol “sicko self pleasing for days on at a time”…

Seriously I really do feel disgusted at the end of a stim binge which is why I do t do them anymore. Always end up watching prob for days losing my kids.

 

[dosesfromcinco]

lol and I was up doing stims alone for days…do they not know that phone is heavily contaminated…I feel so dirty sharing that lol “sicko self pleasing for days on at a time”…

Seriously I really do feel disgusted at the end of a stim binge which is why I do t do them anymore. Always end up watching prob for days losing my kids.

That post nut clarity will get ya, just about every time

 

[negrogesic]

I think you can just get ED50 from lever press responses from morphine trained rats? I could be wrong tho

Yeah that might give you an equianalgesic estimate, but the extent one could attribute to the MOR activation of mitragynine (or by extension 7-OHM) is still unclear because it has multiple mechanisms through which it produces analgesia beyond opioid activity (which is what we're actually trying to determine in this case):

The Effects of Mitragynine and Morphine on Schedule-Controlled Responding and Antinociception in Rats - PMC

Mitragyna speciosa (kratom) may hold promise as both an analgesic and treatment for opioid use disorder. Mitragynine, its primary alkaloid constituent, is an opioid receptor ligand. However, the extent to which the in vivo effects of mitragynine are ...

www.ncbi.nlm.nih.gov

Subjectively the 15mg (i think it was 14.8mg?) of 7-OHM I had didn't feel much more powerful than the equivalent amount of morphine in terms of narcotic effect. But hell some rats who were injected with 7-OHM directly into their peritoneum may potentially disagree with me there

 

[euphoricc]

Yeah man. Talk about lucky. I OD’d off my first small fentanyl binge since i quit like after my 6 time using it because the high sucked and I kept ODing. Well I got a little depressed earlier this year and was flirting with suicide and thought I’d buy 1 gram of fent just in case I wanted to go thru with it.

Well, I was addicted to heavy stims at the time and wanted to come down easier so decided to use the fent but I wasn’t trying to kill myself. I mean I was trim g to be as safe as possible by just taking tiny bumps and waiting before doing more until I got where I wanted cuz you just really don’t know the purity. Well this was fire. They even gave me 3 narcan with it and told me don’t do it by myself it’s fire.

Well should have listened but I don’t know anyone that I trust in that situation that I would want getting higb with. My wife would have killed me if I asked her to watch me while I did some fentanyl and call the squad on me to try to force me into treatment. I get it shit is scary stuff.

Well, u was always up all night on stims and would wait until my wife went to work in the morning to do the fent so she wouldn’t catch me. Well, this particular day I got impatient and went ahead and did a bump. If I would have waited 2 more minutes she would have been gone and I would have been dead. Thankfully she hadn’t left yet. She said she heard my body hit the ground from downstairs and found me turning blue, did CPR because she was in shock and didn’t think about the narcan sitting right above my head on the nightstand.

I came to at OSU Hospital East and they said OD’d and I went strait to the bathroom and pulled out my gram and…BOOM next thing I know im waking up in a different room than my patient room. Like 8-10 people I scrubs around me and honestly looked like a damn operating room.

Im guessing it’s a room they take people to intubate? I don’t tucking know.

Well one doctor was seemed pissed and she was hit too and was like “ Yo, how come you walked in the bathroom fine and were all blue when you came out”

I said idk…and while struggling to come up with an answer super doc saves the day. Another doctor speaks up and says that the narcan probably wore off before the fentanyl did that he took earlier…it happens…

And do you not know that I as discharged that night and went home with my nearly full baggie of fentanyl.

Wild. Surprised the cops didn’t find it. I mean it was in my damn wallet FFS. Sure did take my phone tho. Hate that annoying ass shit. Try to get me to be forced to come talk to you in order to get my phone back fuckinv asses. Trying to get me to snitch and shit…fucking not happening. Trick no good.

Anyhow,…that’s my story and my sticking to it. True story

Edit: Oh and they did take my clothes after the bathroom overdose in the hospital but lo and behold no one searched my wallet yet again. Like WTF you all ain’t even trying?

they stole my phone too hahah they said we gonna search thru ur phone and connect sales blaaah blaa blaaaa fk them