is MS Contin good?

[phatass]

check the bio-availability chart... n decide what you want to do with it..... i know what i would do

 

[kokaino]

morphine is great, but its low bioavailability just sucks.

it's truly the very best prescription opiate high. its most similar to heroin than all others. it just the time release junk and low bioavailability that ruin everything

But no doubt, its the best prescription opiate to IV. Dilaudid is way overrated.

 

[MethaContin]

Just don't go and take the whole 100 mg's. Hopefully you havent done that already. With a tolerance as low as yours, start with 50 mg's. have fun

That's what I was thinking too, that will also be good because you'll still have another half a pill (50mg's) to get high off of later. That's the perfect dose, i would probably (Definatly) snort it as well..........................

 

[haribo1]

Until last year, wax matrix morphine was the only SR available in the UK (MST Continuous). Users had the method of getting the morphine out perfected, 60mg and stronger were well accepted on the black market amongst injecting users. The colour coding appears to be the same as the US. Of course, the 200mg ones were the best (apparently)
One thing in the UK is that we don't add ACAP to opiates to discourage upping the dose, since we discovered that people did so in any case... with the expected outcome.
We now have hydromorphone, either as immediate or sustained release (up to 24mg) AND oxycodone IR (up to 20mg) or SR (up to 80mg).
Of course, we always had Diconal (dipipanone) which wins the 'which has the best rush' stakes hands down...

 

[lenses]

MS contin is the one of the best opiate highs possible. Theres a method to get rid of the wax too somewhere on this site. But you must plug them! Oral bioavailability is something like 10% (reallly low) verses around 90% plugged due to that nasty first pass metabolism.

You're referring to the 60 mg pink ones? Those are a little hard to deal with. But the 30mg white ones are better than any heroin i've ever ever had. I was HEAVILY addicted to those bad boys for around 2 years, with dosages getting over 1500mg.

You guys gotta remember , heroin is a prodrug, it gets metabolized to morphine.

 

[biggerstronger]

morphine sulfate was actually pretty good orally when taken at a equipotent dosage. Even when I had quite a tolerance. 100mg might be just about right or possibly a bit much, but I say crush it/chew it up and take it orally.

 

[phatass]

pleaaaaaase don't snort it... huge waste.... check th BA... 10%if you snort

 

[Newmoonrecord]

pleaaaaaase don't snort it... huge waste.... check th BA... 10%if you snort

i was under the impression that the oral BA of morphine was around 35% snorting would be at least equivalent to oral, since it would get absorbed in the stomach after it drained.

 

[Mr Blonde]

i was under the impression that the oral BA of morphine was around 35% snorting would be at least equivalent to oral, since it would get absorbed in the stomach after it drained.

I would have thought this as well, but maybe there's some mechanism at work that prevents this from happening at it's most effectiveness.

 

[biggerstronger]

Yeah, snorting I believe is actually lower than oral. The same is true with plugging if I remember correctly.

 

[Psych0naut]

Snorting does indeed result in a lower bioavailability than taking it orally(which is already very poor), but it has the advantage of a very fast come up, which makes it much more interesting. Also, there is a certain substance which raised the nasal bioavailability of morphine when snorted to around 60%, which is almost our just as high as with rectal administration, but with an even fast come-up and longer duration. Unfortunenately this potentiator is pretty difficult to obtain, it isn't as easy as getting cimetidine ..

It is not true though, that rectal bioavailability is just as low for morphine as nasal bioavailability(when taken without the potentiator), rectal bioavailability is between 60-70%, around the same bioavailability rate is intramuscular injection.

 

[smokeymcpot42088]

^ Wrong multiple times.

"Certain substance" is chitosan which can be acquired at most health food stores.

Rectal administration does NOT result in 60-70% bioavailability, most places have it listed as 1:1 with oral administration. around 30%. I dont know who decided to compare IM to rectal.

 

[Ungoliath]

What? I used to do multiple MS-Contin 100's daily (morning noon night) and I dont see why all of you are complaining about them, the canadian version (maybe its different) Of MS-Contin (morphine sulphate continuous release) sure, when you first crush them they kinda stay in the pill shape and get a bit of a shine (Obviously you suck the gray coating off first) now flatten it as much as you can, chop it to a razorblade till it gets tiney (use two razorblades and constantly scrape them off each other for the stickeys) make a line, SNIFF

It works, works just as well as sniffing two generic 50's if not better.

 

[loudaudio]

What? I used to do multiple MS-Contin 100's daily (morning noon night) and I dont see why all of you are complaining about them, the canadian version (maybe its different) Of MS-Contin (morphine sulphate continuous release) sure, when you first crush them they kinda stay in the pill shape and get a bit of a shine (Obviously you suck the gray coating off first) now flatten it as much as you can, chop it to a razorblade till it gets tiney (use two razorblades and constantly scrape them off each other for the stickeys) make a line, SNIFF

It works, works just as well as sniffing two generic 50's if not better.

hey if that works great.....but the reality is the medicine itself is incased in a waxy bullshit that you can chop chop to bits and not get alot of it out..... I take it as prescribed and it works great ....just almost no buzz.... thats why alot of folks don't care for it.... sure if you take it morn noon and night.... the natural release of meds from the internal coating would surely make you feel something.... but for my money get other drugs for fun...

 

[Psych0naut]

^ Wrong multiple times.

"Certain substance" is chitosan which can be acquired at most health food stores.

Rectal administration does NOT result in 60-70% bioavailability, most places have it listed as 1:1 with oral administration. around 30%. I dont know who decided to compare IM to rectal.

It is well known that due to the high number of blood vessels surrounding the anal cavities leading to direct absorption into the bloodstream, and skipping first-pass metabolition by the liver, it has a much higher bioavailability factor than oral and nasal administration, on par with intramuscular. Due to extensive first pass metabolition after oral intake, morphine's bioavailability factor is total shit when taken orally, and a big waste. I don't know who decided to compare rectal to oral .. You're avoiding first pass metabolism and have a much larger amount of blood vessels absorbing and distributing the morphine from the anal cavity ..

 

[Darth-_Vidar]

I think the high from these (gray 100 mg PF 100's) is better than an oxy 80. If they are the real ones you can just crush them up in water, filter, and iv. The generic ones require heat to get around the gel, but are still better than any other pill for iv IMO. The pins and needles rush is something some people like more than others, but it's my favorite, I even perfer it to heroin sometimes.

 

[smokeymcpot42088]

"Morphine ~30% oral/rectal, insuffulated- 15-20%, Chitosan(a linear polysaccharide that helps absorb drugs better) has been shown to increase nasal bioavailability of morphine from around 10-20% to over 60%, SC-60%, protein binding 30-40%, half-life is 2-3 hours"

-Bioavailability thread.

I agree in theory it seems like it should work better, in practice, I think it does work better, but on paper not the same case. I also advocate snorting morphine and that appears to be the dumbest thing to possibly do with it, so who knows?

 

[Tbird921]

Not really, there ER I belive although atleast you got the 100mg, I would take a couple to feel it good, oral morphine sucks IMO.

 

[Jared]

I used to deal with lots of the Mallinkrondt generic mscontins, snorting them didnt work as they would gel up in your nose, and they were by far the worst tasting pill I have encountered. Morphine causes alot of nausea, i remember one time in particular I had taken just 60mg at school and i projectile vomited right in the middle of the hallway as I was leaving class. Morphine is not the best opiate but is still a good time.

 

[Wizard_Poo]

Paranoid, what you say about Oxycontin is true......Someone asked me why is Oxycontin so popular.....well its unique in the opiate world in that its the only opiate that does not make you drowsy.....

Dihydrocodeine (popular in the UK) also has a weird kind of stimulating effect. I can stay up for days with a big bottle of DHC.......