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  • BDD Moderators: Keif’ Richards | negrogesic

Benzos Is it possible to be naturally resistant to gaba influencing drugs?

Yeah - I know someone for whom NO opioids have any effect whatsoever.

Obviously the very fist thing a doctor will think is that the patient is exhibiting 'drug seeking behavior' but this person was eventually given a number of chemically unrelated opioids and none had any effect.

There is a strain of mouse used in research. As a class they are termed 'knockout mutations' and as the name suggests, genetic manipulation knocks out a specific biochemical target.

I was VERY relieved to realize that non-pehnolic opioids DO work for me or else I would need 24/7 care. I don't think I would deal with that too well.
 
4DQSAR said:
Well, as I said - I have to be careful with caffeine as that is the only psychoactive I consume and I realize it's to counter the sedative effects of the opioid (and the benzo I take for epilepsy) but even with that, I have to stop at 2.
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I wish caffeine were enough to counter the sedative effects for me. But, I’m a lot less sedated than I used to be. It’s like I’ve developed a tolerance for that, but not the pain killing.
 
I believe prolintane was specifically developed to counter the sedative action of opioids.

Although related to pyrovalerone, it's a much milder stimulant. I believe it's still used medically for that purpose so I wouldn't be surprised to find it turning up on one of those dark markets.

I should add that I have never and will never use a dark market. People seem to forget that however secure an application is, it's only as secure as the OS it's running on. I would be EXTREMELY surprised if Telegram was truly secure, for example. In fact, I'm pretty sure that it has now been hacked.
 
4DQSAR said:
I believe prolintane was specifically developed to counter the sedative action of opioids.

Although related to pyrovalerone, it's a much milder stimulant. I believe it's still used medically for that purpose so I wouldn't be surprised to find it turning up on one of those dark markets.

I should add that I have never and will never use a dark market. People seem to forget that however secure an application is, it's only as secure as the OS it's running on. I would be EXTREMELY surprised if Telegram was truly secure, for example. In fact, I'm pretty sure that it has now been hacked.
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I’ll check that out, thanks! Though I’m surprised by how few RCs are available on the DNM.

Oh yeah, using TG is not safe - although probably fine for casual buyers. But Tails is reasonably secure. And it’s not like getting it on the street is foolproof.
 
4DQSAR said:
I believe prolintane was specifically developed to counter the sedative action of opioids.

Although related to pyrovalerone, it's a much milder stimulant. I believe it's still used medically for that purpose so I wouldn't be surprised to find it turning up on one of those dark markets.

I should add that I have never and will never use a dark market. People seem to forget that however secure an application is, it's only as secure as the OS it's running on. I would be EXTREMELY surprised if Telegram was truly secure, for example. In fact, I'm pretty sure that it has now been hacked.
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Telegram has been compromised for years I bet along with whatsapp and others. I'm sure any state actor would have exploits for those apps.

But what does that have to do with avoiding dark markets?
 
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Because dark markets are usually accessed from private computers.

As I said - a secure environment is ONLY as secure as it's weakest link. In the case of 99% of users, the OS is the weak link.
 
An original xanax-bar was 2mg, 3mg is not that much. The beer probably makes the come-up go unnoticed, after all you did not start from baseline (completely sober) and beer also affects GABA. Once you are on the plateau it is not always a very distinguisable high. If you want to feel the high, start from baseline, put the pill under your tongue, it will dissolve and the come-up will be faster. This way it is more easy to notice the effects.

Then again, benzos to me are more about not feeling. Not feeling anxiety, not feeling stress and enjoying this can sometimes make me a little euphoric. Getting really wasted on benzos takes a lot higher dosages and can be very risky, not advisable at all.

Enjoy your day you GABA-resistantman...
 
Given that alprazolam is considered some ten times more potent, 3mg is a sizable dose. People appear to confuse what such medicines are intended to do. With a couple of exceptions they are used to treat acute anxiety or short-term treatment of severe insomnia. If you reach doses where amnesia becomes a significant issue or mix them with other CNS depressants, they can become unpredictable.

A lot of people do crazy things on higher doses. It was at once humourous and worrying to witness someone consume a handful of clonzaepam, decide they were invisible and go on a shoplifting spree... with the expected result.

I do my best to avoid people who mix alcohol and benzodiazepines. Too unpredictable.
 
Its probably either natural tolerance to benzo type of drugs then, or my slavic drinking habit causing cross tolerance
 
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