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  • BDD Moderators: Keif’ Richards | negrogesic

Benzos Is it possible to be naturally resistant to gaba influencing drugs?

A

Allanford

Bluelighter
Joined
Jun 3, 2023
Messages
72
I decided after years of taking 0.5mg here and there rarely only when Im on a stim comedown to try out xanax purely for that chilled out feeling since I have a lot of it right now. I ended up taking 3mg with 2 beers with very little effect, alongside 1mg of clonozepam as well(little to no tolerance to benzos otherwise). Just an hour afterwards I started drinking with my friends and drank at least 5 beers after that and as I kept drinking I would actually get more chill, calm, alert, cool and collected (+talkative). Now 3h since the party I just feel somewhat calm and remember everything (all those benzos I got perscribed, so they were pharmacy grade). I would of course absolutely never recomend for anyone to actually try this becouse I seem to be 1 in 10000. Im just posting this out of curiousity if anyone has similar effects. If im on a stim comedown they relax me a lot and put me to sleep, so Its kinda weird how I can handle it this well with a decent amount of alcohol and a small tolerance. I know mixing 2 benzos together and then especially drinking booze on top of it all is extremly dangerous and lethal combo and I wont do this again, its just that with every beer I didnt feel any dizzier and didnt breath any slower but got more social and didnt even feel like sleeping? Odd
 
I drink johns wort tea and smoke nicotine, and I heard that both reduce effectiveness of xanax by a fair amount, but 3mg is still 3mg
 
It makes me want to do this every Saturday now because of how it increased euphoria from drinking and made me more charming, unlike speed that turns me into an annoying blabbering fool or when I only drink alcohol and I just get normal drunk or annoying drunk, but I heard and seen what xanax addiction is like so I wont even entertain the idea, no worries
 
I think John Cooper Clark put it best 'First it's fun, then it's not, then it's hell'.

He was in fact referring to opioids and there are regular BL discussions on which produces the worst WD.

It concerns me that people don't see benzos as hard drugs. Since they are used medically they are socially acceptable in a way that opiates are not. But there are a lot of BLers who have struggled for years to stop taking the things.

I'm not saying don't do it - but don't for a moment think that benzodiazepines are soft drugs
 
4DQSAR said:
I think John Cooper Clark put it best 'First it's fun, then it's not, then it's hell'.

He was in fact referring to opioids and there are regular BL discussions on which produces the worst WD.

It concerns me that people don't see benzos as hard drugs. Since they are used medically they are socially acceptable in a way that opiates are not. But there are a lot of BLers who have struggled for years to stop taking the things.

I'm not saying don't do it - but don't for a moment think that benzodiazepines are soft drugs
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I think benzos are as bad as opiods, I do see them as really hard drugs, thats why I barely ever used xanax in small doses for comedowns(2/3 times a month). I just find it weird that I can handle 3mg of xans, 1mg klonopin and 7 beers without blacking out or negative side effects, but rather positive ones. You are completely right though, Im not gonna fuck around with benzos like they are brufen
 
Real shame there is no less addictive substance that could give me similar results because I never felt that cool in my life (except for molly before I lost my magic)
 
And in my country there is thankfully no overperscribed medication so they dont hand them around and warn patients to only use on panic attacks with lowest possible dose. In fact out of all amphetamine speed I sadly took in my life I have never seen a single aderall or ritalin pill, I even saw heroin a few times but never codeine or vicodin, since the doctors are careful perscribing these things there is 0 black market for it
 
Oh and a question, since I took these big doses tonight will my tolerance drop back to 0,5mg when I end up needing it for a stim comedown within a week or 2? Ive screwed myself up royally if now I end up having to take 3mg for every comedown, there will be none left before april
 
I also needed large doses of benzos when I didn't have a tolerance. For me I think it was because my alcohol tolerance was very high, because there is a certain degree of cross tolerance. Do you think this might be the case for you?
 
Mixing benzos and alcohol is super risky, so I'm glad you're okay. Everyone reacts differently, but it sounds like you might have a naturally high tolerance. Still, be careful, man. It's not worth pushing your luck.
 
Delusion of sobriety is a big thing ... also some people Flip out really bad and violently on benzos/alcohol and i mean people who hate violence etc.... be really careful... people have ended up in jail for long time taking one benzo on top of alcohol and no memories of beating someone to death etc
 
Alcohol tolerance is likely to increase benzodiazepine tolerance. I've seen people being dried out and even in the local hospital, they were handing out pretty heroic doses of chlorodiazepoxide (nordiazepam prodrug).

I remain to be convinced that chlorodiazepoxide is any less problematic than an equipotent dose of other benzodiazepines. It's less abuses mainly because it's rarely available.
 
Of course. People can be naturally resistant to anything. There are many drugs which have little or no effect on me. And then there are a few that I am hypersensitive to. I’m quite resistant to the hypnotic effects of GABAergics.
 
There is a medical term for people who generally respond far less to psychoactive medications than is usual - they are termed 'hard heads'. Often it's unclear if the medicine simply isn't acting and/or the subconscious of that person fights to retain homeostasis.
 
Well, I don't know you very well but from the general demenour of your posts, I had gained the impression that you are someone who simply seeks to feel 'normal' and chronic severe pain is presenting you with problems in reaching that quite reasonable goal.

My only real quirk is that phenolic opioids have no effect on me whatsoever. Be it morphine, hydromorphone, oxymorphone or even ketobemidone - if it has a phenol, my body gluconates and removes it. VERY annoying.
 
4DQSAR said:
Well, I don't know you very well but from the general demenour of your posts, I had gained the impression that you are someone who simply seeks to feel 'normal' and chronic severe pain is presenting you with problems in reaching that quite reasonable goal.

My only real quirk is that phenolic opioids have no effect on me whatsoever. Be it morphine, hydromorphone, oxymorphone or even ketobemidone - if it has a phenol, my body gluconates and removes it. VERY annoying.
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Thanks, I guess? I think I have a very strong sense of self and I very much like to stay in control and clearheaded so that’s the psychological aspect. And then physiologically I am a super metaboliser in multiple ways. Liver enzyme profile + hyperactive cell pumps, & probably more because at least peripherally I have three times the typical number of nerves.
 
Well, as I said - I have to be careful with caffeine as that is the only psychoactive I consume and I realize it's to counter the sedative effects of the opioid (and the benzo I take for epilepsy) but even with that, I have to stop at 2.
 
It IS apparently possible to be naturally resistant to the effects of opiates, to the point where even outrageous doses do precisely nothing. This has been documented by at least one physician who chronicled a patient consuming an insane amount of morphine which would have killed several people, yet remaining entirely unaffected.

So it would not surprise me if some individuals had a genetic inability to process benzodiazepines, rendering them immune to their effects.
 
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