My friend Homer say's DOI had more body load than DOC. Also, DOC was more visual for Homer. Here are some bad effects: DOI for Homer caused long term (2months and counting) "internal vein tremors", which is the best way Homer can describe it. A warning also, Homer say's never mix 3.5 mg DOI with 3.5 mg DOC or even 2mg DOC. Homer say's he feels like he has Serotonin Syndrome (3 weeks and counting). The Serotonin Syndrome effects Homer is feeling are agitation, muscle twitching, and a wierd warm and sometimes slight headache feel in his brain. Homer is currently taking Vitex (Herbal supplement) to increase progesterone levels in his body, he heard these break down serotonin.