Opioids I want to use opioids but I'm on suboxone

[4DQSAR]

For starters work on getting your daily dose down. Bupe will saturate like 98% of your receptors at like 4-6mg.

No it won't.

Sci-Hub: are you are robot?

Even 16mg leaves 5% of receptors unoccupied and of course being a COMPETITIVE partial agonist which still undergoes the usual binding-unbinding cycle means a full agonist (or super-agonist) with (much) higher affinity will eventually result in insurmountable agonism.

I sort of assume carfentanil was the response to buprenorphine since it's affinity is so ridiculously high, it's half-life so unexpectedly long so it will shatter the 'buprenorphine blockade'. It's so lipophilic that mesurment of plasma concentrations has repeatedly failed to match subjective duration because it hides in fatty tissue throughout the body.

There aren't many human reports from users who knowingly consumed carfentanil but it's recognized (experienced) duration is a lot longer than measurment of plasma levels would suggest. The same is true of etonitazazine in that it demonstrates a two-phase dose-response which again is because while the plasma half-life isn't that long, it sits in fatty tissue safe from enzymatic metabolism.

 

[Xyborg]

No it won't.

Sci-Hub: are you are robot?

Even 16mg leaves 5% of receptors unoccupied and of course being a COMPETITIVE partial agonist which still undergoes the usual binding-unbinding cycle means a full agonist (or super-agonist) with (much) higher affinity will eventually result in insurmountable agonism.

Meant to type 90% not 98, my apologies (will edit my original reply). However, I still stand by my statement of lowering the daily dose. Doctors push crazy high bupe doses that in the vast majority of cases is just unnecessary.

But yes, an opioid (afaik there is not a natural opiate with such a high binding affinity) with a high enough binding affinity, at the appropriate dose will knock bupe off the receptors that it is supposed to be "blocking."

Bupe is also lipophilic. That, along with its fairly long half-life, are what make getting off/withdrawal so hellish. This is also the cause of many people struggling to even start maintenance therapy.