I have got yopo seeds back when they were legal in the UK.
I would have to snort 5g or more of the dry-fried, peeled and crushed seeds to get anything, and it's just generally nasty to do when you can get pure dmt off the DNMs or TG or whatever, and smoking 20mg in a glass meth pipe.
If someone put some powdered yopo in front of me I would probably give it a try for nostalgia, but it's not in the same league as shrooms or acid and of course the pure powder.
I have seen native south American tribes blow powder which I assume is treated yopo up each other's noses with long tubes, the receiver rocking and tensing in anguish, maybe yopo powder delivered that way is quite effective, but pure dmt is cheap and not too hard to get, and quite safe.
Only lasts about 20 mins, but fuck me - I've went travelling on that stuff.
From a harm reduction standpoint you're probably OK with any form of dmt as long as you take into account set and setting. Trusted friends, no worries or real chances of surprises, and maybe experience with mushrooms or something to prepare yourself for the wild ride.
DMT feels like the crack of psychedelics. Just don't do it with arseholes who might put you on edge or use your vulnerable state to spike you with more. I've got radge stories from dmt, but certainly don't advocate its use, nor dissuade.