@Gaffy : would you please post real structures not SMILES structures it is pointless as nobody is going to bother converting them. You can use this website if you do not want to host images.
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N&PD Moderators: Skorpio | someguyontheinternet
I Like to Draw Pictures of Random Molecules
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That's why I use the STP link to host the image, and as soon as I'll have access to a computrr again I will definitly edit all my posts with images
sekio
Bluelight Crew
I will add images... just maybe in future you can start posting images, IUPAC names or even derivatives of "common names", like "4a-allyl-morphine" instead of "OC1=C2O[C@]3(CC=C)[C@]45C2=C(C=C1)C[C@@H](N(CC5)C)[C@]4([H])C=C[C@@H]3O".
Hahah.. Sorry.. And thanks a lot! 
BIG NEWS! I have found a supplier who is ready to look into producing BLÆZØCAINE! It seems dimethocaine isn't very popular anymore so they are looking for a legal replacement, and this fits perfectly! Yay!
Edit: Sekio, you're the best!
Could someone tell me the IUPAC of the blæzøcaine, COC(=O)C(COC(=O)C1=CC=CC=C1)C1CCCN1C
Would this be right? :
1-(2-(N-MethylPyridine))-2-Carbomethoxy-3-Benzoyloxylate
BIG NEWS! I have found a supplier who is ready to look into producing BLÆZØCAINE! It seems dimethocaine isn't very popular anymore so they are looking for a legal replacement, and this fits perfectly! Yay!
Edit: Sekio, you're the best!
Could someone tell me the IUPAC of the blæzøcaine, COC(=O)C(COC(=O)C1=CC=CC=C1)C1CCCN1C
Would this be right? :
1-(2-(N-MethylPyridine))-2-Carbomethoxy-3-Benzoyloxylate
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Nagelfar
Bluelight Crew
^I'd like to see that one
sekio
Bluelight Crew
I personally don't see this being active at all (ester hydrolysis will be rapid) and it looks nothing like any active NDRIs
sekio
Bluelight Crew
I could care less what STP says, I'm just pointing out that methyl esters tend to get cleaved very rapidly (cocaine's does...)
also in general deleting single bonds out of compounds reduces the affinity towards transporters, c.f. 2,3-seco-fentanyl or diampromide vs fentanyl... orders of magnitude difference in potency
also your "8-methyl dmt" is really 2-methyl dmt..
also in general deleting single bonds out of compounds reduces the affinity towards transporters, c.f. 2,3-seco-fentanyl or diampromide vs fentanyl... orders of magnitude difference in potency
also your "8-methyl dmt" is really 2-methyl dmt..
Erowid Online Books : "TIHKAL" - #34 2-ME-DMT
Entry #34 2-ME-DMT from TiHKAL by Alexander & Ann Shulgin.
www.erowid.org
I would still like to try it in the least. And yes, I was more interested in its affinity for the HT6 and the compounds derived thereof; also I used the counting of carbons you pointed out a few posts ago, which goes like a phenyl compound
Oh, and finally it seems synthing Blæzøcaïne small scale is around ten to one which is just too much for an RC that is aimed to replace Dimethocaine which goes for three/four to one. This is not a price naming..
A funny compound, active at GABA receptors that are completely unknown to me. I wonder if it has any addictive properties and if it's euphoric. Any input on these receptor? I've got time for reading
swisstargetprediction.ch
(Found a way to host this image as it was already uploaded)
Found a way to screenshot/upload on imgur but the linking add-on from BL disappears upon entering the link, I don't know why it worked with the one above..
Anyway, here's the STP link.
swisstargetprediction.ch
I've got an interesting new fentanyl I'll post tomorrow.
Edit: Searching for theanine derivatives active at orexine ligands (found one, might post if someone is interested in it) I came across some dopamine activity and after 2-3 changes came up with this, which is I think what I was looking for searching for HT6 activity without visuals! I present:
swisstargetprediction.ch
Sekio, you were talking about unknown format NDRIS, here's a SNDRI to for your liking :
CCC(C(CC)C1=CC=CC=C1)C1CCCN1C
swisstargetprediction.ch
New MDMA alternative??
Oh, and finally it seems synthing Blæzøcaïne small scale is around ten to one which is just too much for an RC that is aimed to replace Dimethocaine which goes for three/four to one. This is not a price naming..
A funny compound, active at GABA receptors that are completely unknown to me. I wonder if it has any addictive properties and if it's euphoric. Any input on these receptor? I've got time for reading
SwissTargetPrediction
swisstargetprediction.ch
Found a way to screenshot/upload on imgur but the linking add-on from BL disappears upon entering the link, I don't know why it worked with the one above..
Anyway, here's the STP link.
SwissTargetPrediction
swisstargetprediction.ch
I've got an interesting new fentanyl I'll post tomorrow.
Edit: Searching for theanine derivatives active at orexine ligands (found one, might post if someone is interested in it) I came across some dopamine activity and after 2-3 changes came up with this, which is I think what I was looking for searching for HT6 activity without visuals! I present:
SwissTargetPrediction
swisstargetprediction.ch
Sekio, you were talking about unknown format NDRIS, here's a SNDRI to for your liking
:CCC(C(CC)C1=CC=CC=C1)C1CCCN1C
SwissTargetPrediction
swisstargetprediction.ch
New MDMA alternative??
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sekio
Bluelight Crew
Isn't that a prolintane analogue? (remember please post images and not just SMILES)
What's the fascination with 5HT6 agonism? What's that supposed to do?
if you remove the ester linkage and a methylene, and swap the methylpyrrolidine for a piperidine, you get methylphenidate.
What's the fascination with 5HT6 agonism? What's that supposed to do?
probably because it's not as trivial a synthesis as you think
if you remove the ester linkage and a methylene, and swap the methylpyrrolidine for a piperidine, you get methylphenidate.
Isn't that a prolintane analogue? (remember please post images and not just SMILES)
What's the fascination with 5HT6 agonism? What's that supposed to do?
probably because it's not as trivial a synthesis as you think
if you remove the ester linkage and a methylene, and swap the methylpyrrolidine for a piperidine, you get methylphenidate.
With my small knowledge, I'd guess=>
Start with Beta-MethoxyAlaninol, Chloride => Chlorinated right next to the ketone. First step. Then N-Methylpyrridine, Chlorinate the 2 position - 2 step. React the two, you got yourself precursor n°3. Then dilute benzoic acid, the precursor n°3 and heat for 2-3 days, removing water. Extract with ether, gas with HCl and there you've got Blæzøcaïne!
Check these out, decided to make a Dump, too many to post one by one. Tonight's thinking results:
Edit: it seems just posting ttheimgur link and not trying to add it via the image link add-on works
HT6 seems to play a role in alzheimer, I was tired of inventing drugs so i wanted to come up with some kind of a medecine ^^
And yes it is prolintane inspired
.
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sekio
Bluelight Crew
This is like, textbook example of how organic synthesis doesn't go. Do you just magically get the intermediates to just link together? (with expulsion of chlorine gas, natch)
Are you aware of any other side reactions in your proposed synthesis? What reagents do you propose to chlorinate a non-activated ester (presumably you mean methyl 3-methoxypropanoate as "beta-methoxy-alaninol" (don't you mean serinol
?) has no ketone - only an amine, and 2 primary alcohol last I checked) and/or the 2' position of a pyrrolidine selectively?Dilute benzoic acid? Why?
Anyway I could go on... it's not as simple as you would make it out to be. Do some reading on process chemistry and maybe come back to the drawing board next year
Or pull out the stops and make a compound actually tenable to large-ish scale synthesis:
You can have that one, for free...
You're not bringing genius innovation to pharmacy with your brilliant observations here. There is binge-generating a bunch of structures and feeding them into STP during a bender, & then there is rational pharmacy design, and the venn diagram doesn't see a lot of overlap...
(sarcasm aside) What in the brain hasn't been found or speculated to have some role in Alzheimers disease?
You will notice nobody else in this thread takes themselves too seriously ...
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sekio
Bluelight Crew
Isophenidine analog?
Nagelfar
Bluelight Crew
Replace/substitute the phenols on phenolphthalein with different cyclohexanes ring systems having any kind of branches or heteroatoms and try to make a drug with abuse liability.
That's what I would do if I could here quarantined with just my phone, maybe I could entice someone else to do so, I just want to see something like it.
That's what I would do if I could here quarantined with just my phone, maybe I could entice someone else to do so, I just want to see something like it.
SIGMA, MU, KAPPA, DELTA, DOPA, NE, SER, NMDA, etc, all on one molecule, I present:
swisstargetprediction.ch
As for the IUPAC, Phenyl-1-CycloHexyl-1-MethylCyclopentyl-(2-Pyrridinemine)
SwissTargetPrediction
swisstargetprediction.ch
As for the IUPAC, Phenyl-1-CycloHexyl-1-MethylCyclopentyl-(2-Pyrridinemine)
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sekio
Bluelight Crew
^ somehow I doubt that binds mu, with no oxygens & 1 nitrogen
frankly i dont think it will bind dat either, that's a big ball of lipophilic goo
same for a lot of some of your other "inventions" which seem to be "take a large lipophilic group and jam a 2-methylaminopropane onto it"
in fact I would say you are doing a good job of illustrating the limitations of STP, many of those compounds are thoroughly too bulky to be DAT substrates. You will notice there is no pyrene analog of amphetamine nor buckyball analogs.
1,6-di(phosphocholine)-alpha-glucopyranose
i dont know, a nootropic maybe
frankly i dont think it will bind dat either, that's a big ball of lipophilic goo
same for a lot of some of your other "inventions" which seem to be "take a large lipophilic group and jam a 2-methylaminopropane onto it"
in fact I would say you are doing a good job of illustrating the limitations of STP, many of those compounds are thoroughly too bulky to be DAT substrates. You will notice there is no pyrene analog of amphetamine nor buckyball analogs.
1,6-di(phosphocholine)-alpha-glucopyranose
i dont know, a nootropic maybe
polymath
Bluelight Crew
Taurine is a bit like the amino acid glycine, except that it's a sulfonic acid and not carboxylic. The one in Sekio's post is a phosphate ester and a quaternary ammonium compound (not a normal amine).
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