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N&PD Moderators: Skorpio | someguyontheinternet
I Like to Draw Pictures of Random Molecules
- Thread starter nuke
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Protonated means having a proton, H+
Doesn't seem relevant here? So it makes your question very
A charge is not *really* exchanged in nitros, it's balanced over the oxygens. https://upload.wikimedia.org/wikipe.../Nitro-group-2D.png/1024px-Nitro-group-2D.png https://en.wikipedia.org/wiki/Formal_charge
They just want to stick to the octet rule, but for the heteroatoms in nitro groups there isn't a more optimal spread of electrons possible than the one in that img ^
Anyway dinitroamines exist but may be explosive, esp certain derivatives. The nitro groups much rather want to leave and jump ship as gases like nitrogen - which as gas is so much more voluminous that the sudden increase yields an explosion.
and yea in some cases where there's a bunch of electrons (in bonds or lone pairs, esp with formal charge) it's worth paying attention whether they can conjugate / find a balance to flipflop, domino in a molecule towards other groups. With nitro's even dinitroamines there isn't really a possibility of what they call intramolecular interaction (look it up).. i dont think so
The drawn structures are kinda like doodles yeah. I don't think drawing outrageous strings of atoms together and slowly learning why that is a faux pas is the way to learn org chem as others said.
If it floats your boat, cool... but don't fool yourself, pick up that org chem textbook if you wanna really get it better.
Doesn't seem relevant here? So it makes your question very
A charge is not *really* exchanged in nitros, it's balanced over the oxygens. https://upload.wikimedia.org/wikipe.../Nitro-group-2D.png/1024px-Nitro-group-2D.png https://en.wikipedia.org/wiki/Formal_charge
They just want to stick to the octet rule, but for the heteroatoms in nitro groups there isn't a more optimal spread of electrons possible than the one in that img ^
Anyway dinitroamines exist but may be explosive, esp certain derivatives. The nitro groups much rather want to leave and jump ship as gases like nitrogen - which as gas is so much more voluminous that the sudden increase yields an explosion.
and yea in some cases where there's a bunch of electrons (in bonds or lone pairs, esp with formal charge) it's worth paying attention whether they can conjugate / find a balance to flipflop, domino in a molecule towards other groups. With nitro's even dinitroamines there isn't really a possibility of what they call intramolecular interaction (look it up).. i dont think so
The drawn structures are kinda like doodles yeah. I don't think drawing outrageous strings of atoms together and slowly learning why that is a faux pas is the way to learn org chem as others said.
If it floats your boat, cool... but don't fool yourself, pick up that org chem textbook if you wanna really get it better.
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Bagseed
Bluelighter
once again, you cannot have bonds like that sticking from an aromatic ring. maybe learn about orbital hybridization (in this case sp2 on the carbon)Attempting a tropane-cyclized amphetamine. Amphetatropane?
Dresden
Bluelighter
- Joined
- Feb 2, 2010
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- 3,212
If I get into graduate school, I plan to start collecting some serious antibiotic royalties starting in around 12 to 15 years. I would say that's a more likely scenario than my successfully completing the 8 year Ph.D program that comes along with it. But first I have to somehow apply and be accepted to the program, which is at Emory University in Atlanta.
"I took too much NBOMe, now I'm at ICU at Emory!"--Rehab.
"I took too much NBOMe, now I'm at ICU at Emory!"--Rehab.
Nagelfar
Bluelight Crew
I prefer to call them unconventionally interesting...
Then they wouldn't be so unconventionally interesting. Circumventing errors can derive novel exceptions, it takes a village. (Besides, I like saying I'm self-taught, maybe another eight years and I can fool somebody)
Serious attempt:
RTI-430 + Tamagnan
pharmakos
Bluelighter
Nagelfar, the guys were being a bit too harsh on you, but some of the concepts they've mentioned for you to look into get covered in like week three of freshman year of a chemistry degree. Snort some coke and read about orbitals some weekend.
Midnight Sun
Bluelighter
clomethiazole dimer (aka bastard child between clomethiazole & sulbutiamine)
Nagelfar
Bluelight Crew
I'm always at the public library to get online, so any prevalent/common texts to suggest worth literally "checking-out" from the library would be appreciated.
...
Anyhow, these anti-emetic serotonin subtype receptor antagonists (5-HT3) are very close to cocaine analogues:
Zatosetron:
Bemesetron:
Ricasetron:
Granisetron:
So would the following in the same class of above, i.e. Ondansetron:
Be modified to be a MAT reuptake inhibitor / DARI? Could someone give me an attempt who can overlap it and, perhaps cocaine, troparil or methylphenidate, in 3D and give a 2D of one they think may float that function?
Bagseed
Bluelighter
also peroxides in a drug? no thx
bruh http://www.masterorganicchemistry.com/getting-started/ is what i used to get ahead in school and now im actually studying chem and still using the site
aced126
Bluelighter
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- May 18, 2015
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- 1,047
There exist a few drugs with peroxide FGs in them, artemisinin being quite a common one. But you're right, peroxides are generally not a great idea unless the drug is required in extremely low dosages.
pharmakos
Bluelighter
we're talking about introductory level chemistry textbooks here. there's so many of them out there that it is hard to say which ones any individual library would have. some of the chemistry stuff that you aren't aware of that people have suggested you look up, like say molecular orbital theory, was covered in my high school chemistry textbook. there's just so many possible references for this stuff out there that no one is going to be able to give you a single name to grab. just go to the reference material section and see what ya can find.
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