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I Like to Draw Pictures of Random Molecules

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Nagelfar,

Your many cocaine analogues tend to border on the monstrous, bizarre, and impossible. Just saying, that's all.
 
Protonated means having a proton, H+
Doesn't seem relevant here? So it makes your question very :?

A charge is not *really* exchanged in nitros, it's balanced over the oxygens. https://upload.wikimedia.org/wikipe.../Nitro-group-2D.png/1024px-Nitro-group-2D.png https://en.wikipedia.org/wiki/Formal_charge
They just want to stick to the octet rule, but for the heteroatoms in nitro groups there isn't a more optimal spread of electrons possible than the one in that img ^

Anyway dinitroamines exist but may be explosive, esp certain derivatives. The nitro groups much rather want to leave and jump ship as gases like nitrogen - which as gas is so much more voluminous that the sudden increase yields an explosion.

and yea in some cases where there's a bunch of electrons (in bonds or lone pairs, esp with formal charge) it's worth paying attention whether they can conjugate / find a balance to flipflop, domino in a molecule towards other groups. With nitro's even dinitroamines there isn't really a possibility of what they call intramolecular interaction (look it up).. i dont think so

The drawn structures are kinda like doodles yeah. I don't think drawing outrageous strings of atoms together and slowly learning why that is a faux pas is the way to learn org chem as others said.

If it floats your boat, cool... but don't fool yourself, pick up that org chem textbook if you wanna really get it better.
 
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Better yet, go to college and take years of chemistry and other science classes like the rest of us.
 
Well, you're definitely going to need to invent that new amazing coke analogue if you have student debts.
 
Nagelfar said:
Attempting a tropane-cyclized amphetamine. Amphetatropane?

AjbpH.jpg
Click to expand...
once again, you cannot have bonds like that sticking from an aromatic ring. maybe learn about orbital hybridization (in this case sp2 on the carbon) ;)
 
If I get into graduate school, I plan to start collecting some serious antibiotic royalties starting in around 12 to 15 years. I would say that's a more likely scenario than my successfully completing the 8 year Ph.D program that comes along with it. But first I have to somehow apply and be accepted to the program, which is at Emory University in Atlanta.

"I took too much NBOMe, now I'm at ICU at Emory!"--Rehab.
 
Actually, Rehab said LSD, but I didn't want to be lectured on the low likelihood of an actual LSD overdose.
 
Dresden said:
Nagelfar,

Your many cocaine analogues tend to border on the monstrous, bizarre, and impossible. Just saying, that's all.
Click to expand...

I prefer to call them unconventionally interesting...

Dresden said:
Better yet, go to college and take years of chemistry and other science classes like the rest of us.
Click to expand...

Then they wouldn't be so unconventionally interesting. Circumventing errors can derive novel exceptions, it takes a village. (Besides, I like saying I'm self-taught, maybe another eight years and I can fool somebody)

esdbH.jpg


Serious attempt:

RTI-430 + Tamagnan

AXcjw.jpg
 
Nagelfar, the guys were being a bit too harsh on you, but some of the concepts they've mentioned for you to look into get covered in like week three of freshman year of a chemistry degree. Snort some coke and read about orbitals some weekend.
 
pharmakos said:
Nagelfar, the guys were being a bit too harsh on you, but some of the concepts they've mentioned for you to look into get covered in like week three of freshman year of a chemistry degree. Snort some coke and read about orbitals some weekend.
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I'm always at the public library to get online, so any prevalent/common texts to suggest worth literally "checking-out" from the library would be appreciated.

...

Anyhow, these anti-emetic serotonin subtype receptor antagonists (5-HT3) are very close to cocaine analogues:
Zatosetron:
180px-Zatosetron.svg.png

Bemesetron:
180px-Bemesetron.svg.png

Ricasetron:
180px-Ricasetron.svg.png

Granisetron:
180px-Granisetron_structure.svg.png


So would the following in the same class of above, i.e. Ondansetron:
225px-Ondansetron_skeletal.svg.png


Be modified to be a MAT reuptake inhibitor / DARI? Could someone give me an attempt who can overlap it and, perhaps cocaine, troparil or methylphenidate, in 3D and give a 2D of one they think may float that function?
 
Bagseed said:
also peroxides in a drug? no thx
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There exist a few drugs with peroxide FGs in them, artemisinin being quite a common one. But you're right, peroxides are generally not a great idea unless the drug is required in extremely low dosages.
 
Sorry Nagelfar, I didn't mean to be overly harsh with you like that, but a lot of your sulfur creations in particular would simply never hold together.
 
Nagelfar said:
I'm always at the public library to get online, so any prevalent/common texts to suggest worth literally "checking-out" from the library would be appreciated.
Click to expand...

we're talking about introductory level chemistry textbooks here. there's so many of them out there that it is hard to say which ones any individual library would have. some of the chemistry stuff that you aren't aware of that people have suggested you look up, like say molecular orbital theory, was covered in my high school chemistry textbook. there's just so many possible references for this stuff out there that no one is going to be able to give you a single name to grab. just go to the reference material section and see what ya can find.
 
This one is intended to be a shorter acting methamphetamine fairly quickly metabolized into an inactive methylamino acid.

3-phenyl-2-methylaminopropan-1-one.png
 
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