• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

Status
Not open for further replies.
your last molecule reminds me of Jimscaline, SKL. IIRC it is a putative potent psychedelic and has high affinity for 5HT2 receptors.

i was looking at 8-OH-DPAT a few weeks ago too and wondering what could be tweaked in there. though, the one derivative that i found that seemed to have the most potential was plain 2-aminotetralin: it substitutes for amphetamine and supposedly is a 5HT and NE releasing agent. though one article reported it caused hypothermia in rodents... very weird (5HT1A agonism may be? i think 8-OH-DPAT does that. anyway it's the opposite one would expect from an entactogen). does anybody know anything about it? i wasn't able to find much literature and zero anedoctal reports of experience with it or the N-methyl homologue...

MDMAT was around but it was barely active. the MD fn group in MDMA is exceptional and never does anything good to other molecules, so there could be a good stimulant hiding behind MDMAT...

anybody knows anything about 2-AT or 2-MAT? may be i'm missing something and it's just boring.
 
9-(3-fluoropyridin-2-yl)-3-methyl-12-nitro-2%2C4%2C5%2C8%2C11-pentaazatricyclo%5B8.4.0.0%C2%B2%2C%E2%81%B6%5Dtetradeca-1(14)%2C3%2C5%2C8%2C10%2C12-hexaene.png


Flunitrazolam/Pynazolam/Zapizolam hybrid.
 
zw1kbZp.jpg


prolly super duper bad for the ole circulatory system...

Is there any information on pyridine analogs of amphetamine?
 
Last edited:
SKL said:
trifludrone. I like it.

triflephedrone?
trifledrone?
trifle-drone?

it is probably sort of a trifle. I'd try it though TBH.
Click to expand...

Well, might not be so safe. I've recently found out that 5-trifluoro-2-AI is 50% as neurotoxic as norfenfluramine, 5-iodo-2-AI has some neurotoxicity as well while 2-AI is non-neurotoxic. So it looks like putting a halogen or a trifluoromethyl group on the ring may be risky no matter how safe the parent compound is. Cathinones are not solely reuptake inhibitors, they act as releasers too, so 4-CMC & 4-BMC might be neurotoxic too to an unknown extent. Something to look into for some researchers.
 
There's that possibly not probably possible (I've been told, not possible actually) aliphatic N-C-O group again.
 
Nexus_Tripper said:
Looks similar to Flephedrone.
Click to expand...

it does, but should be significantly more selective for serotonin

adder said:
Well, might not be so safe. I've recently found out that 5-trifluoro-2-AI is 50% as neurotoxic as norfenfluramine, 5-iodo-2-AI has some neurotoxicity as well while 2-AI is non-neurotoxic. So it looks like putting a halogen or a trifluoromethyl group on the ring may be risky no matter how safe the parent compound is. Cathinones are not solely reuptake inhibitors, they act as releasers too, so 4-CMC & 4-BMC might be neurotoxic too to an unknown extent. Something to look into for some researchers.
Click to expand...

This is interesting. Was not aware of this wrt halo-substitutions. Some people were touting flephedrone to be less toxic than mephedrone.

The trifluoro molecule I posted is mostly 5htergic and is indeed both a releaser and a reuptake inhibitor
 
2,3,4-tricarbomethoxytropane.png


SWEET. Good luck synthesizing that, though, although I'm sure it's far from impossible.
 
Last edited:
1-(3,4-methylenedioxy-5-methoxyphenyl)-2-ethylaminopropane.png


N-ETHYL-MMDA

Probably supersedating for an amphetamine and requiring heroic dosages, but also probably largely "legal" in the US and China (but not in the UK as I understand it). It might even turn out to be a sedative-hypnotic!!! It probably gives great nystagmus (horizontal eye wiggles indicating extreme rolling statuses; vertical eye wiggles for PCP) and, hopefully, massive mydriasis (pupil dilation) if it even works. A cinch to make compared to many research chemicals. Might not do anything.
 
Last edited:
Something like a methylphenidate/pipradrol hybrid is certainly possible, not sure how potency would compare to MPH though.

methyl%202-hydroxy-2-phenyl-2-(piperidin-2-yl)acetate.png
 
Interesting ^

I wish we would see 3C-MAL...

http://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=2195

Mescaline is beautiful, then to escaline it seems to get a little less interesting - also with proscaline and allylescaline somewhat lackluster (though all of them may be excellent for a museum level or zen-like enhancement / augmentation if not really psychedelic - unless, as always, you take a lot of it -), then with MAL it sounds quite wild and psychedelic again...

Then also take that 3C-P sounds like it is considered better than 3C-E...

Combine ideas. Profit!
 
Last edited:
Status
Not open for further replies.
Top