I Like to Draw Pictures of Random Molecules

[Nagelfar]

^is this all that's required to make a possible pethidine/cocaine intermediate, or would the phenyltropane variant be more viable?

^Is there any rules that would make a sulfur-(when benzene is substituted)-heteroatom untenable? (perhaps another sulfur on the benzoyloxy connecting "C1" benzene position to top it off?)

^I just think this would make a good analogue. The 3β-styrene in place of the 3β-benzoyloxy makes it longer like the 3β-carbamoyl; but since the styrene alkylphenyltropane already has great affinity, and the unsubstituted 3β-carbamoyl does so much better with the meta-nitro despite how gimped it is when alone (and clubcard's raving review of the para-nitro on the shorter phenyl linkage), I think this would be a wonderful addition. The cis-propenyl can be removed, I just had it there to make it a probable SDRI.

 

[Dresden]

A free phenolic group is important for activity; ethers show very little mu affinity and as such only function as prodrugs (like codeine). The above molecules might eventually get metabolised to reveal the free phenolic group but probably not at great concentrations as other metabolites will likely result first like the cleavage of the ester.

I'm really sorry if this is a stupid question, but what molecules are you referencing here?

 

[aced126]

The opioid/sndras SKL posted.

 

[SKL]

Thanks aced good feedback if anyone can't tell I'm the rankest sort of amateur just an ex-druggie clinical guy who likes to think up fanciful stuff so negligible opioid activity and probably too complicated to be decent stimulants yeah?

 

[Soulfake]

2,9-bis(2H-1,3-benzodioxol-5-ylmethyl)-6,13-bis(2H-1,3-benzodioxole-5-carbonyl)-3,5,10,12-tetramethyl-1,7-dioxa-3,5,10,12-tetraazacyclotetradecane-4,11-dione

2x Methylone + 2x MDMA in one molecule (or double-dimerized (bk-&)MDMA)

edit: why haven´t dimerized drugs been made? Like putting two molecules like amphetamine or morphine via a simple linker atom together which would be hydrolized in the body.

 

[SKL]

Quite a structure.

Baroque is a word that comes to mind ...

This (OPSIN) rendering more resembles a sort of mandala ...

Mandalamine?

Will it break down to the appropriate constituents?

 

[Dresden]

(S)-2-methylamino-1-phenylpropane is a much more elegant name for this than methamphetamine.

 

[belligerent drunk]

edit: why haven´t dimerized drugs been made? Like putting two molecules like amphetamine or morphine via a simple linker atom together which would be hydrolized in the body.

What would be the point?

 

[aced126]

Possibly better pharmacokinetic properties.

 

[SKL]

trifluoromephedrone

It has been made at least academically, I can find next to nothing about it but here, compared to methcathinone (not mephedrone), relatively selective for serotonin ...

Has this been made or tasted in our world though? yet another serotonin realising warm cuddly mdai type drug?

 

[Soulfake]

What would be the point?

I thought about circumventing law´s, maybe some molecules (if they would correctly hydrolize) could give interesting opportunities for "cocktails" like an oxycodone molecule linked together with methamphetamine. Similar to how picamilon works where Gaba is hydrolized from Niacine which are simply linked together on the ketone via oxygen.
The only downside I could imagine is that it could take some time for the molecule to hydrolize, so it may not be useful for iv consumption and effects would take longer to be felt (which could make for safer drugs or alternatives for stuff like methadone, imagine a type of heroin with the same effects but if used i.v. it would take almost the same time to get a rush as if was swallowed.

There wouldn´t be so many exotic research chemicals if this would be a possible way to go and at least some kind of such drugs would have appeared somewhere though, I think.

 

[SKL]

imagine a type of heroin with the same effects but if used i.v. it would take almost the same time to get a rush as if was swallowed.

Vyvanse does this with dexedrine as the breakdown occurs in the red blood cells (not the stomach acids as some assume and is often the case for XR products...)

 

[adder]

trifluoromephedrone

How about trifludrone?

 

[SKL]

How about trifludrone?

trifludrone. I like it.

triflephedrone?
trifledrone?
trifle-drone?

it is probably sort of a trifle. I'd try it though TBH.

 

[Midnight Sun]

all this talk of fluoro-drone...

 

[roi]

 

[roi]

 

[Nagelfar]

^I had dreams about hornets and wasps last night after drawing this one.

^MAT torpedo?

 

[SKL]

So this this came into my mind ...

8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to be discovered.

Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a 5-HT7 receptor agonist and serotonin reuptake inhibitor/releasing agent as well.

In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic, anorectic, antiemetic, hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.

What can we play with?

A cousin to mephedrone? (7-OH-DPAT is more D2-selective and substitutes for cocaine[?] in rats)

The cliché mentioned in the very first post of this thread?

From thence, a rather baroque TMAish elaboration on the three most interesting positional isomers:

although n.b. I found only one very obscure reference to 4,5,6-TMA which says, in keeping with the general trend of the series, it is inactive.

And this doesn't look fun ...

But here is RDS-127, which seems to have some promising properties:

What else?

Following the above (and perhaps reinventing a wheel somewhere), and more mescaline-ish version of TMA-ish thing above:

There are a bunch of interesting things in this genre ...

 

[Nexus_Tripper]

Uniteed Kingoms Legal M.X.E analog