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I Like to Draw Pictures of Random Molecules

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sekio said:
Do we need a campaign against aminal abuse?
tcgxLY4.png


These guys are hydrolytically and enzymatically unstable, they are valid compounds indeed, but they have a tendency to decompose to ammonia and the parent aldehyde (!)
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well now I know that %)

for shame I am bad drug designer. go directly to jail, do not pass go

crmt28 said:
Here's the same molecule on a different angle, plus the piperidine version aside. Looks very LSD like! I wonder if adding a double bond somewhere could help with the activity.

J00A3iP.png
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I was going to propose subbing a sulfur in there but... something's nagging me about it
 
There needs to be a double bond where the O is to achieve planarity. Switching O-->S isn't going to help because the molecule still won't be planar. 5-(CH3-S)-DMT might be interesting, though.
 
JPDs4Wf.png


2 stimulants (already detailed in a patent... probable cocaine/mdma replacements, triple releasers/reuptake inhibitors) and a cannabinoid.
 
The 2-phenyl morpholine's are very interesting. Have the 2-phenyl 3-methyl morpholine's been tested?
 
Dresden said:
There needs to be a double bond where the O is to achieve planarity. Switching O-->S isn't going to help because the molecule still won't be planar. 5-(CH3-S)-DMT might be interesting, though.
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You missed what I was saying, dude, but fair enough, I was half awake and made a vague post

Reason I suggested the sulfur was to move the nitrogen "left in X" - normally I'd have just done that with the oxygen there but per sekio that's bad juju. Had nothing to do with planarity

Here let me draw:

ERpL4e0.png


This way you can have the nitrogen in it's holy grail spot like you have in LSD while maintaining the same # of lone pair electrons as you would with the oxygen... that was my thinking. now go from there with planarity.

it's a weird looking sub, though

while I'm here and yapping about sulfur,

1peA36m.png


balanced releaser or hyperthermic hell?
 
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^so this is basically MPA without the N-methyl and the sulfur on another position... what could this mean regarding activity?

edit: ok after having another look at your molecule: nevermind :D
 
The sulfur amphetamine molecule has 5 bonds on 2 (numbers 3 and 4) carbons of its benzene ring and does not and will not exist. However, you could try 2-thia-IAP (the 5 membered ring saturated version of your (almost) creation; I've often wondered about 2-oxa-IAP myself. Note: I'm using replacement nomenclature there.) I've never seen a nitrogen-carbon-sulfur either in a molecule, I don't think. Whether that means it's like nitrogen-carbon-oxygen containing molecules, which don't exist, or not I don't know, but I'm inclined to think nitrogen-carbon-sulfur molecules are chemically verboten as well.
 
Dresden said:
The sulfur amphetamine molecule has 5 bonds on 2 (numbers 3 and 4) carbons of its benzene ring and does not and will not exist. However, you could try 2-thia-IAP (the 5 membered ring saturated version of your (almost) creation; I've often wondered about 2-oxa-IAP myself. Note: I'm using replacement nomenclature there.) I've never seen a nitrogen-carbon-sulfur either in a molecule, I don't think. Whether that means it's like nitrogen-carbon-oxygen containing molecules, which don't exist, or not I don't know, but I'm inclined to think nitrogen-carbon-sulfur molecules are chemically verboten as well.
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http://www.chemindustry.com/chemicals/01539609.html

Isobenzothiophene is a thing. If you wanna be autistic about it then lol OK 1 extra double bond in the benzene
 
That and MD-MPH and MD-4-MAR. Isothienobenzene may be a real chemical, but not the way you've drawn it.
 
hm, how quickly would that get metabolized? i don't know enough about pharmacokinetics, but my gut tells me that it would get eaten up pretty quickly.
 
while we're at it, someone needs to feed roi some phenylalanine, I bet he will say it's an amphetamine replacement with fewer side effects and more euphoria 8)
 
You just lost that bet. Stop the random hate maybe...

Scepticism doesn't hurt, but unsupported "inactive" does.

Looking forward to the video of you eating your hat.
 
well, excuse me if your claim goes against all known SAR of amphetamines. i think claiming that a simple organic compound known probably since the 1800s is a stimulant should be backed up with at least one piece of literature data?

do you realize that this means clandestine amphetamine manufacturers need not bother with the whole process of making phenylacetone and can just go PAA-->the amide in one step? do you really thunk nobody's tried that?? (hint: DEA has found people making phenylacetamide before, and it wasn't exactly mentioned as an active stimuylant, more like a fuckup!)

and you don't exactly have a history of posting any sort of analytical data to back up your claims, either? do you even know you have phenylacetamide? can you provide any sort of data to back up your claim? MS, NMR, melt point, fucking TLC or something? no?

how about you go back to shilling on drugs forum, clearly you don't have the ability to swim with the big fish here. big claims require big evidence and i see nothing but you trolloping around saying "oh this compound XYZ is a novel stimulant!!!!!!!!" - never providing anything but anecdotes.
 
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