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I Like to Draw Pictures of Random Molecules

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given the recent craze with 3-fluoro-phenmetrazine (and the legendary status of phenmetrazine itself), i think this would be good:

3,4-methylenedioxy-phenmetrazine
jHUOHsF.png
 
Also, has this ever been tried before? Phosphate groups are strongly fat-soluble, and this theoretically should be more fat soluble than morphine.... the diacetyl groups in heroin are meant for increased fat solubility. Well, structurally, this would be to morphine what psilocybin is to psilocin:

JD6BVwP.png


Diphosphorylmorphine. Perhaps one could call it phosphorin?
 
1-(3,4,5-trimethoxyphenyl)-2-pyrrolidinyl-(n)-pentan-1-one.hcl
1-(3,4,5-trimethoxyphenyl)-2-pyrrolidinyl-(n)-pentane.hcl
1-(1,3-benzodioxole-5-yl)-2-pyrrolidinyl-propane.hcl
1-phenyl-2-pyrrolidinyl-propane.hcl
 
It's late and I don't have much to bring to the table this time except this syncan:

uLmWaxM.png


feel free to substitute propofol for thymol if that tickles your fancy more, basically designed this with fairly benign metabolites in mind, thymol doesn't seem that terrible afaik as far as phenols are concerned...
 
2-methoxy-hydrocodone.hcl (creates a 3,4,5-alkylated-trioxybenzene arrangenment not terribly unlike mescaline's)
2,3-methylenedioxy-oxymorphone.hcl (creates an MMDA like arrangenment of alkylated aromatic oxygens)

Synthesizing these looks to be a tough problem, though. I believe it would have to be done from scratch.
 
N-3,4-methylenedioxyphenyl-(su)fentanyl.hcl
N-3,4,5-trimethoxyphenyl)-(su)fentanyl.hcl

In contrast with the above substituted morphinan narcotics, these four compounds are entireably, easily do-able from scratch.
 
The benzene ring homologue of naphazoline, a stimulant vasoconstrictive used in certain brands of eye drops to do away with ocular redness. Also, its 3,4-methylenedioxybenzene analogue. These two are possibly dangerous. Caution is advised.
 
crmt28 said:
Inorganic Psychedelics! Would any of these be possible?

4-boryl-2,5-dimethoxy-phenethylamine / 4-methylboryl-2,5-dimethoxy-phenethylamine / 4-dimethylboryl-2,5-dimethoxy-phenethylamine



4-boryl-2%2C5-dimethoxy-phenethylamine.png
4-methylboryl-2%2C5-dimethoxy-phenethylamine.png
4-dimethylboryl-2%2C5-dimethoxy-phenethylamine.png




or maybe oxyboryl compounds instead:

4-oxoboryl-2,5-dimethoxy-phenethylamine / 4-hydroxyboryl-2,5-dimethoxy-phenethylamine / 4-(methylhydroxyboryl)-2,5-dimethoxy-phenethylamine / 4-dihydroxyboryl-2,5-dimethoxy-phenethylamine


4-oxoboryl-2%2C5-dimethoxy-phenethylamine.png
4-hydroxyboryl-2%2C5-dimethoxy-phenethylamine.png
4-%28methylhydroxyboryl%29-2%2C5-dimethoxy-phenethylamine.png
4-dihydroxyboryl-2%2C5-dimethoxy-phenethylamine.png
Click to expand...

Interesting proposition. The selenium-substititued 2C exists in real life and didn't work, but these might.

I was also wondering if 4-silicon substituted 2C's would work.
 
I never really like chemistry to begin with due to the complexity of it. Yeah, I find it complex.

But I must admit, that molecule drawing is epic! Good stuff!
 
RE: borane-2c compounds; "plain" boranes have a tendency to be, uhm, "energetic" compounds (triethylborane is used to ignite afterburners because it is hypergolic with oxygen - ignites instantly with no spark) and the boronic acids (B-OH compounds are both highly polar and have a tendency to trimerize). If you could make the boronic acid you would likely find it was inactive.

Silicon analogues of 2C drugs might be interesting, but silicon needs a quaternary carbon to be stable. Maybe sila-DOM - replace the carbon that has the amine on it with a Si?
 
I think most or all DARIs or NDRIs need that amino function you lopped out, skybluemolly...

On that basis I imagine you will find that no receptor or transporter will find it 'legally binding' :P
 
Solipsis said:
I think most or all DARIs or NDRIs need that amino function you lopped out, skybluemolly...

On that basis I imagine you will find that no receptor or transporter will find it 'legally binding' :P
Click to expand...

O-2172 is a research chemical with some DRI effects that didn't need the nitrogen group. The potency is around 1/3 that of methylphenidate and ethylphenidate. Perhaps Shell-247 may be 1/4 to 1/9 the potency of methylphenidate. Since things like prolintane, cyclohexylaminopropane(norpropylhexedrine, an active metabolite of propylhexedrine) and propylhexedrine are not very potent, but are still stimulating enough, and since O-2172 seems to be selective for dopamine, maybe Shell-247 may act as a mild to moderate stimulant. One could hope.
 
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