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I Like to Draw Pictures of Random Molecules

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Sweet. In which case, I will take full advantage of your hospitality.

noname03.png


I was aiming for a beta-ketone analogue of 4-MAR, but I was a little unsure of where that extra oxygen atom should go. Did I do it right this time?

Also, any reason why a BK version would be a bad idea? I know the beta-ketones have a tendency to be less...good....than their parent compounds- bk-MDMA being a prime example. If the same relationship applies here, is there a substitution that could be made to increase the serotonin fun times, and then make it a beta-ketone? Is there any point?
 
glenjih said:
Also, any reason why a BK version would be a bad idea? I know the beta-ketones have a tendency to be less...good....than their parent compounds- bk-MDMA being a prime example. If the same relationship applies here, is there a substitution that could be made to increase the serotonin fun times, and then make it a beta-ketone? Is there any point?
Click to expand...

Well that's not always the case... mephedrone is certainly better than 4-methylmethamphetamine, and I'd actually be more interested in trying methcathinone than methamphetamine. (I hear that methcathinone does nothing for focus, and I find that the focus strongly detracts from the recreational potential of amphetamine. Accordingly I've heard methcathinone described as an excellent party drug, even better than MDMA according to some.)
As far as the aminorex family goes, I don't think we know much about their structure activity relationships. Note that it will almost certainly not display the same patterns as amphetamines', e.g. there's little reason to think that slapping a methylenedioxy on it would make it more "rolly" or something. Anecdotally, 4-MAR produces somewhat of an MDMA-like high, and I've not heard the same for aminorex. Perhaps if you wanted to maintain that you could try some subtle substitutions on the 4-MAR molecule, or some different substitutions in the 4 position (one of which you've already done). So overall we don't know much about aminorexes, but I have no reason to think that the molecule you drew wouldn't work (although I honestly don't know that much about SAR stuff), it seems at least worth testing on a few guinea pigs :P

How about this one?
14o4ze9.png

4-Methyl-5-phenyl-2-amino-furan (I think?)
The electron donating capability of the furan oxygen should create a very stable conjugate acid I think... and in tryptamines the nitrogen in the indole ring doesn't really do anything at all (at least for agonist activity), maybe it's the same for aminorexes? If so this could be very potent...
 
2w3uqlh.png


Kinda.. a double methamphetamine

Can anyone tell me what this would actually do?
 
A compound that can form copper complexes with different shapes depending in the chirality (3d configuration) of the stereocentres of the molecules (of which there are two)

Anyway, your double meth probably wouldn't do anything, except perhaps act as a a2 adrenergic agent, as it probably wouldn't be able to be taken up into the presynaptic cell to act on VMAT2, nor would it have the same effect once it got there.
 
What about... 2,3,4-trinitro-amphetamine

I'm very inexperienced with the SAR
 
I would not touch that trinitroamphetamine. Aromatic nitro compounds are often highly toxic.

Di-nitro compounds in particular, such as dinitrophenol. DNP has been used by fat buggers who want to get slim, although its banned, and rightly so. It works by uncoupling oxidative phosphorylation, so the body burns ATP yet gaining less energy. Calories intaken get used up, but without giving the energy they usually would. Not good at all, for mitochondria etc. And it raises body temperature massively, literally turning up the heat on the oven. Sometimes lethally so. Its unpredictable, and noxious stuff. It has been known to cause cataracts also, along with other side effecs.

Not sure if tri-nitro aromatics possess the same sort of ability to fuck with the proton gradient within mitochondria, but I would NOT touch this one. It is likely to be nice and colorful though. Bright yellow I bet. Nitro compounds are often yellow. Such as DON, and having seen the nitrostyrene that corresponds when reduced with LAH, Al/Hg amalgam, zinc/GAA etc to 2C-D (2,5-dimethoxyphenyl-4-methyl-beta-nitrostyrene), before recrystallization from first water, then boiling MeOH it was a lurid shade of bright orange, but post-rxtylization it appeared in the form of purrty clearish golden-yellow crystals.

Aromatic nitro compounds in general are bad news for the body, especially dinitro compounds like DNP, which act as proton ionophores. I would take DON, or 2C-N, but I find them only acceptable due the small amounts needed to produce the intended effects, by weight.

Do tri-nitro aromatics possess the same degree and/or types of toxicity as DNP and its ilk?
 
Considering the likely precursors for trinitro amphetamine are trinitrobenzenes, I would suspect that even handling the precursors would land you in an "explosive situation" shall we say.
 
Depends, TNT needs some force to set it off, its stable enough to be hot melt casted into bomb cases for military applications, etc. . Not too far removed from trinitrobenzenes. I'd be a bit leery of the tetranitrostyrene though.

I sure as hell wouldn't be taking any of the resultant amphetamine. Would possibly be an amusing lab exercise, ala Shulgin with his comments on the hypothetical 2C-Po and 2C-At. but just the same, the potential toxicity of trinitroamphetamine would completely rule it out though. I imagine that could cause a serious case of explosive diarrhea, to say the least=D
 
glenjih said:
Sweet. In which case, I will take full advantage of your hospitality.

noname03.png


I was aiming for a beta-ketone analogue of 4-MAR, but I was a little unsure of where that extra oxygen atom should go. Did I do it right this time?

Also, any reason why a BK version would be a bad idea? I know the beta-ketones have a tendency to be less...good....than their parent compounds- bk-MDMA being a prime example. If the same relationship applies here, is there a substitution that could be made to increase the serotonin fun times, and then make it a beta-ketone? Is there any point?
Click to expand...

Found a compound that looks like yours.
http://en.wikipedia.org/wiki/Pemoline
200px-Pemoline.svg.png
 
I think this is best suited for ADD, instead of getting possible pseudo-science BDD guesses as answers
Is there a way to calculate or get a good estimate on how much your metabolic rate has increased while under the influence of amphetamine(s)
 
^ Ring-contracted arylcyclohexylamines (arylcyclopentylamines?) are considered to be inactive, the ring has to have 6 and exactly 6 members for good NMDA effects.

I do want to see N-ethyl-norketamine.
 
Is there a reason why we only see propyl - pentylpyrovalerone derivatives and not any longer chains?

Is there an alpha-propylphenethylamine? What's the SAR like here compared to amphetamines?
 
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